Academic Journal
Phospholipid remodeling interplays with auxin signaling to modulate cellular reprogramming in Arabidopsis regeneration.
| Τίτλος: | Phospholipid remodeling interplays with auxin signaling to modulate cellular reprogramming in Arabidopsis regeneration. |
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| Συγγραφείς: | Chang P; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China., Yang X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Liu X; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Guo S; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhou J; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., He M; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Li Z; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Xu E; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Xin W; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China., Hu Y; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China.; National Center for Plant Gene Research, Beijing 100093, China., Xu C; Key Laboratory of Plant Molecular Physiology and State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, China National Botanical Garden, Beijing 100093, China. |
| Πηγή: | The Plant cell [Plant Cell] 2026 Jun 02; Vol. 38 (6). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9208688 Publication Model: Print Cited Medium: Internet ISSN: 1532-298X (Electronic) Linking ISSN: 10404651 NLM ISO Abbreviation: Plant Cell Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: Rockville, MD : American Society of Plant Physiologists, c1989- |
| Ιατρικοί όροι (MeSH): | Indoleacetic Acids*/metabolism , Indoleacetic Acids*/pharmacology , Arabidopsis*/physiology , Arabidopsis*/metabolism , Arabidopsis*/genetics , Regeneration*/physiology , Phospholipids*/metabolism , Cellular Reprogramming*, Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/genetics ; Phosphatidic Acids/metabolism ; Plant Growth Regulators/metabolism ; Signal Transduction ; Gene Expression Regulation, Plant ; Plants, Genetically Modified |
| Περίληψη: | In vitro regeneration of plants from tissues such as leaf or root explants typically starts with auxin-induced formation of a pluripotent cell mass termed callus. This cellular reprogramming is essential for the subsequent regeneration of shoots or roots. However, whether or how lipid metabolism is involved in callus formation and thus plant regeneration remains largely unclear. Here, we report that phospholipid remodeling is critical for auxin-induced callus formation during the regeneration of Arabidopsis thaliana. We show that phospholipid metabolism changes dynamically during auxin-induced pluripotent callus formation, and that interfering with the phospholipid metabolic pathway enhances or dampens callus formation induced by auxin. We further demonstrate that the phospholipid metabolite phosphatidic acid (PA) inhibits callus formation by binding to auxin signaling repressors of the INDOLE-3-ACETIC ACID INDUCIBLE (IAA) family and enhancing their stability, thereby decreasing auxin signaling and the callus-forming program. Our findings reveal the molecular interplay between phospholipid metabolism and auxin signaling during plant regeneration and identify developmental programs that may participate in this process. (© The Author(s) 2026. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Competing Interests: | Conflict of interest: The authors declare no conflict of interests. |
| Grant Information: | 2024YFF1000700 National Key R&D Program of China; 32470329 National Natural Science Foundation of China; 32170317 National Natural Science Foundation of China |
| Substance Nomenclature: | 0 (Indoleacetic Acids) 0 (Arabidopsis Proteins) 0 (Phospholipids) 0 (Phosphatidic Acids) 0 (Plant Growth Regulators) |
| Entry Date(s): | Date Created: 20260608 Date Completed: 20260624 Latest Revision: 20260624 |
| Update Code: | 20260625 |
| DOI: | 10.1093/plcell/koag169 |
| PMID: | 42257601 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1532-298X |
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| DOI: | 10.1093/plcell/koag169 |