Academic Journal
Προβολή σε EDS

Unveiling the Nutraceutical Potential of Yam Dioscorea alata L.: A Comprehensive Review.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Unveiling the Nutraceutical Potential of Yam Dioscorea alata L.: A Comprehensive Review.
Συγγραφείς: Prajapati KK; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India., Pandey R; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India. rpcg12@gmail.com., Pandey V; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India., Upadhyay KM; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India., Singh S; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India., Pandey VS; Department of Botany, St. Andrew's PG College, Gorakhpur, 273001, U.P., India., Pandey VN; Experimental Botany and Nutraceutical Laboratory, Department of Botany, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur, 273009, U.P., India. vnpgu@yahoo.co.in.
Πηγή: Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2026 Jun 06; Vol. 81 (2). Date of Electronic Publication: 2026 Jun 06.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8803554 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-9104 (Electronic) Linking ISSN: 09219668 NLM ISO Abbreviation: Plant Foods Hum Nutr Subsets: MEDLINE
Imprint Name(s): Publication: Dordrecht : Kluwer Academic
Original Publication: [Dordrecht] : Martinus Nijhoff, c1987-
Ιατρικοί όροι (MeSH): Dioscorea*/chemistry , Plant Extracts*/pharmacology , Dietary Supplements*, Antioxidants/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Phytochemicals/pharmacology ; Hypoglycemic Agents/pharmacology ; Saponins/pharmacology ; Anthocyanins/pharmacology ; Plants, Medicinal/chemistry ; Humans ; Functional Food
Περίληψη: Dioscorea alata L. (water yam and purple yam) is a traditionally important food and medicinal plant widely used in Asia and the Pacific Islands. It has long been utilized in traditional medicine for treating weakness, inflammation, menstrual disorders, wound healing, and gastrointestinal ailments. The dual role as a dietary and therapeutic resource highlights its ethnopharmacological importance and supports the need for scientific validation. This review evaluates existing knowledge on the nutraceutical potential of D. alata. Recent studies report diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, anticancer, antihypertensive, cardioprotective, and gut microbiome-modulatory effects. These activities are largely attributed to bioactive compounds such as saponins and anthocyanins. The species shows considerable promise as a functional food and natural therapeutic resource. Moreover, its cultivation and utilization may contribute to food security and public health (SDG 2 and 3). Further, phytochemical and clinical studies are required to fully establish its nutraceutical value.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Consent for Publication: Not Applicable. Competing Interests: The authors declare no competing interests.
References: Agre PA, Uwimana B, Nkouaya Mbanjo EG, Ferguson M, Bhattacharjee R, Nyine M, Banda V, Peteti P, Mouritala S, Ismail KS, Amah D, Kolombia Y, Batte M, Tripathi JN, Nakato V, Shah T, Swennen R, Asfaw A, Ismail RY, Tripathi L, Mushoriwa H (2026) Advances and prospects of genomic-assisted breeding in roots, tubers, and banana crops. Front Plant Sci 17(2026):1744272. https://doi.org/10.3389/fpls.2026.1744272.
Agama-Acevedo E, Santana-Galeana RS, Rosell CM, Bello-Perez LA (2025) Exploring underused starchy food crops to extend their consumption: Mexico as case of study. Plant Foods Hum Nutr 80(2):113. https://doi.org/10.1007/s11130-025-01347-2.
Jahan FN, Hasibuzzaman ASM, Nadim MKA, Rahim MA, Hossain MM, Rahman MH, Samanta AK (2026) Unravelling the inter and intra species variations in cultivated yam (Dioscorea sp) landraces in Bangladesh through phenotypic traits, proximate compositions and mineral nutrients. Heliyon 12(1). https://doi.org/10.1016/j.heliyon.2025.e44311.
Liang S, Zeng Y, Wang L, Wu J, Cao M, Chen X, Jiang Q (2026) Cultivated and wild yam (Dioscorea alata L.) starches: physicochemical properties, in vitro digestibility, and related correlations. Int J Food Sci Tech 61(1):vvag006. https://doi.org/10.1093/ijfood/vvag006.
Adomeniene A, Venskutonis PR (2022) Dioscorea spp.: comprehensive review of antioxidant properties and their relation to phytochemicals and health benefits. Molecules 27(8):2530. https://doi.org/10.3390/molecules27082530.
Wang P, Shan N, Ali A, Sun J, Luo S, Xiao Y, Zhou Q (2022) Comprehensive evaluation of functional components, biological activities and minerals of yam species (Dioscorea polystachya and D. alata) from China. LWT 168:113964. https://doi.org/10.1016/j.lwt.2022.113964.
Kaur B, Khatun S, Suttee A (2021) Current highlights on biochemical and pharmacological profile of Dioscorea alata: a review. Plant Arch 21(1):552–559. https://doi.org/10.51470/plantarchives.2021.v21.S1.085.
Awalia R, Tahir MM, Zainal Z (2023) Evaluation of organoleptic and physicochemical properties of ice cream by fortifying of purple yam (Dioscorea alata L.) and purple sweet potato (Ipomoea batatas L.). AIP Conf Proc 2596(1):040003. https://doi.org/10.1063/5.0121666.
Sarofa U, Wardhani RRRP (2022) The characteristics of synbiotic yoghurt ice cream made from ice cream mix and purple yam yoghurt (Dioscorea alata). J Funct Food Nutraceutical 3(2):57–62. https://doi.org/10.33555/jffn.v3i2.82.
Moriya C, Hosoya T, Sakakibara H, Shimoi K, Kumazawa S (2025) Absorption of acylated anthocyanins from purple yam extract in rats. Biosci Biotechnol Biochem 89(3):431–437. https://doi.org/10.1093/bbb/zbae206.
Yang X, Wang Q, Zhang X, Li L, Cao X, Zhou L, Huang Y, Sun G, Chen Y (2023) Purple yam polyphenol extracts exert anticolitis and anticolitis-associated colorectal cancer effects through inactivation of NF-κB/p65 and STAT3 signaling pathways. J Agric Food Chem 71(32):12177–12189. https://doi.org/10.1021/acs.jafc.3c00346.
Qiu P, Chen J, Wu J, Wang Q, Hu Y, Li X, Wang X (2023) The effect of anthocyanin from Dioscorea alata L. after purification, identification on antioxidant capacity in mice. Food Sci Nutr 11(10):6106–6115. https://doi.org/10.1002/fsn3.3547.
Yun Y, Shi H, Wang Y, Yang F, Zhang Y, Feng H, Chen J, Wang X (2023) Pre-protection and mechanism of crude extracts from Dioscorea alata L. on H<sub>2</sub>O<sub>2</sub>-induced IPEC-J2 cells oxidative damage. Animals 13(8):1401. https://doi.org/10.3390/ani13081401.
Chen T, Hu S, Zhang H, Guan Q, Yang Y, Wang X (2017) Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model. Food Funct 8(2):659–669. https://doi.org/10.1039/C6FO01273F.
Haddaway NR, Page MJ, Pritchard CC, McGuinness LA (2022) PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and open synthesis. Campbell Syst Rev 18(2):e1230. https://doi.org/10.1002/cl2.1230.
Dufie WMF, Oduro I, Ellis WO, Asiedu R, Maziya-Dixon B (2013) Potential health benefits of water yam (Dioscorea alata). J Food Funct 4(10):1496–1501. https://doi.org/10.1039/c3fo60064e.
Wanasundera JP, Ravindran G (1994) Nutritional assessment of yam (Dioscorea alata) tubers. Plant Foods Hum Nutr 46(1):33–39. https://doi.org/10.1007/BF01088459.
Otegbayo BO, Oguniyan DJ, Olunlade BA, Oroniran OO, Atobatele OE (2017) Characterizing genotypic variation in biochemical composition, anti-nutritional and mineral bioavailability of some Nigerian yam (Dioscorea spp.) land races. J Food Sci Technol 55(1):205–216. https://doi.org/10.1007/s13197-017-2913-0.
Ratsimbazafy MK, Sharp PA, Razanamparany L, Rajaonah MT, Rokotoarison F, Khoja KK, Wilkin P, Howes MJR (2023) Wild edible yams from Madagascar: new insights into nutritional composition support their use for food security and conservation. Food Sci Nutr 12(1):280–291. https://doi.org/10.1002/fsn3.3757.
Patel KS, Karmakar N, Desai KD, Narwade AV, Chakravarty G, Debnath MK (2019) Exploring of greater yam (Dioscorea alata L.) genotypes through biochemical screening for better cultivation in south Gujarat zone of India. Physiol Mol Biol Plants 25(5):1235–1249. https://doi.org/10.1007/s12298-019-00698.
Salehi B, Sener B, Kilic M, Sharifi-Rad J, Naz R, Yousaf Z, Santini A (2019) Dioscorea plants: a genus rich in vital nutra-pharmaceuticals-a review. Iran J Pharm Res 18:68–89. https://doi.org/10.22037/ijpr.2019.112501.13795.
Siqueira MVBM, Nascimento WFD, Silva LRG, Ferreira AB, Silva EFD, Ming LC, Veasey EA (2014) Distribution, management and diversity of yam local varieties in Brazil: a study on Dioscorea alata L. Braz J Biol 74(1):52–61. https://doi.org/10.1590/1519-6984.17112.
FAO (2010) Roots, tubers, plantains and bananas in human nutrition. Food and Agriculture Organization of the United Nations, Rome. http://www.fao.org .  Accessed 12 Feb 2026.
Sheikh N, Kumar Y, Misra AK, Pinokiyo A (2009) Status documentation of Dioscorea L. (Dioscoreaceae) in Meghalaya: an approach towards food security. Pleione 3(1):74–82.
Pandey R, Pandey VS, Pandey VN (2024) Nutraceutical metabolites, value addition and industrial products for developing entrepreneurship through edible fleshy fungi. In: Shukla AC (ed) Entrepreneurship with microorganisms. Academic Press, Cambridge, pp 293–328. https://doi.org/10.1016/B978-0-443-19049-0.00010-4.
Kumar S, Das G, Shin HS, Patra JK (2017) Dioscorea spp. (a wild edible tuber): a study on its ethnopharmacological potential and traditional use by the local people of Similipal Biosphere Reserve, India. Front Pharmacol 8:52. https://doi.org/10.3389/fphar.2017.00052.
Liu YH, Lin YS, Liu DZ, Han CH, Chen CT, Fan M, Hou WC (2009) Effects of different types of yams (Dioscorea alata) products on the blood pressure of spontaneously hypertensive rats. Biosci Biotechnol Biochem 73(6):1371–1376. https://doi.org/10.1271/bbb.90022.
Lu YL, Chia CY, Liu YW, Hou WC (2012) Biological activities and applications of dioscorins, the major tuber storage proteins of yam. J Tradit Complement Med 2(1):41–46. https://doi.org/10.1016/S2225-4110(16)30069-4.
Riley CK, Wheatley AO, Asemota HN (2006) Isolation and characterization of starches from eight Dioscorea alata cultivars grown in Jamaica. Afr J Biotechnol 5(17):1528–1536. https://doi.org/10.4314/ajb.v5i17.43151.
Baah FD, Maziya-Dixon B, Asiedu R, Oduro I, Ellis WO (2009) Nutritional and biochemical composition of D. alata (Dioscorea spp.) tubers. J Food Agric Environ 7(2):373–378.
Silambarasan R, Nair AK, Maniyan G, Vijaya R, Nair RVR, Kumar SN, Sasidharan S (2025) Exploring the molecular mechanism of Dioscorea alata L. for the treatment of menstrual disorders using network pharmacology and molecular docking. Heliyon 11(4):e42582. https://doi.org/10.1016/j.heliyon.2025.e42582.
Vishnu VR, Jyothi AN, Sheela MN, Sreekumar J (2023) Identification of anthocyanins in a purple yam (Dioscorea alata) accession and their in vitro antiproliferative activity. J Plant Biochem Biotechnol 32(3):467–477. https://doi.org/10.1007/s13562-023-00828-2.
Srivichai S, Hongsprabhas P (2020) Profiling anthocyanins in Thai purple yams (Dioscorea alata L.). Int J Food Sci 2020(1):1594291. https://doi.org/10.1155/2020/1594291.
Ochoa S, Durango-Zuleta MM, Osorio-Tobón JF (2020) Techno-economic evaluation of the extraction of anthocyanins from purple yam (Dioscorea alata) using ultrasound-assisted extraction and conventional extraction processes. Food Bioprod Process 122:111–123. https://doi.org/10.1016/j.fbp.2020.04.007.
Jiang S, Xie H, Zuo Y, Sun J, Wu D, Shu X (2024) Structural and functional properties of polysaccharides extracted from three Dioscorea species. Int J Biol Macromol 281(4):136469. https://doi.org/10.1016/j.ijbiomac.2024.136469.
Mao X, Lu J, Huang H, Gao X, Zheng H, Chen Y, Gao W (2018) Four types of winged yam (Dioscorea alata L.) resistant starches and their effects on ethanol-induced gastric injury in vivo. Food Hydrocoll 85(2018):21–29. https://doi.org/10.1016/j.foodhyd.2018.06.036.
Li T, Chen L, Xiao J, An F, Wan C, Song H (2018) Prebiotic effects of resistant starch from purple yam (Dioscorea alata L.) on the tolerance and proliferation ability of Bifidobacterium adolescentis in vitro. Food Funct 9(4):2416–2424. https://doi.org/10.1039/c7fo01919j.
Li T, An F, Teng H, Huang Q, Zeng F, Song H (2017) Comparison of structural features and in vitro digestibility of purple yam (Dioscorea alata L.) resistant starches by autoclaving and multi-enzyme hydrolysis. Food Sci Biotechnol 27(1):27–36. https://doi.org/10.1007/s10068-017-0206-z.
Jiang S, Cen J, Zhou Y, Wang Y, Wu D, Wang Z, Sun J, Shu X (2023). Physicochemical characterizations of five Dioscorea alata L. starches from China. Int J Biol Macromol 237:124225. https://doi.org/10.1016/j.ijbiomac.2023.124225.
Houngbo ME, Desfontaines L, Diman JL, Arnau G, Mestres C, Davrieux F, Rouan L, Beurier G, Marie-Magdeleine C, Meghar K, Alamu E O, Otegbayo B O, Cornet D (2024) Convolutional neural network allows amylose content prediction in yam (Dioscorea alata L.) flour using near infrared spectroscopy. J Sci Food Agric 104(8):4915–4921. https://doi.org/10.1002/jsfa.12825.
Rinaldo D, Rolland-Sabaté A, Lange D, Pétro D (2024) Varietal and environmental influences on organoleptic and cooking quality of water yam (Dioscorea alata) landraces. J Sci Food Agric 104(8):4729–4737. https://doi.org/10.1002/jsfa.12873.
Lin PL, Lin KW, Weng CF, Lin KC (2009) Yam storage protein dioscorins from Dioscorea alata and Dioscorea japonica exhibit distinct immunomodulatory activities in mice. J Agric Food Chem 57(11):4606–4613. https://doi.org/10.1021/jf8038499.
Ratnaningsih R, Richana N, Suzuki S, Fujii Y (2018) Effect of soaking treatment on anthocyanin, flavonoid, phenolic content and antioxidant activities of Dioscorea alata flour. Indones J Chem 18(4):656–663. https://doi.org/10.22146/ijc.23945.
Sakthidevi G, Mohan VR (2013) Total phenolic flavonoid contents and in vitro antioxidant activity of Dioscorea alata L. tuber. J Pharm Sci Res 5(5):115–119.
Zhang Y, Shi H, Yun Y, Feng H, Wang X (2022) The effect of anthocyanins from Dioscorea alata L. on antioxidant properties of perinatal Hainan black goats and its possible mechanism in the mammary gland. Animals 12(23):3320. https://doi.org/10.3390/ani12233320. (PMID: 10.3390/ani12233320364968419735849)
Feng H, Shi H, Yang F, Yun Y, Wang X (2023) Impact of anthocyanins derived from Dioscorea alata L. on growth performance, carcass characteristics, antioxidant capacity, and immune function of Hainan black goats. Front Vet Sci 10:1283947. https://doi.org/10.3389/fvets.2023.1283947.
Tamaroh S, Sudrajat A (2021) Antioxidative characteristics and sensory acceptability of bread substituted with purple yam (Dioscorea alata L.). Int J Food Sci 2021(1):5586316. https://doi.org/10.1155/2021/5586316.
Yang F, Xie T, Zhang Y, Feng H, Zhang H, Wang X, Shi H (2026) Dioscorea alata Linn. anthocyanins improve antioxidant status, rumen function, and meat quality in Hainan black goats: in vitro and in vivo evidence. Food Chem 505:147903. https://doi.org/10.1016/j.foodchem.2026.147903.
Dvorakova M, Landa P (2017) Anti-inflammatory activity of natural stilbenoids: a review. Pharmacol Res 124:126–145. https://doi.org/10.1016/j.phrs.2017.08.002.
Dey P, Chowdhuri SR, Sarkar MP, Chaudhuri TK (2016) Evaluation of anti-inflammatory activity and standardisation of hydro-methanol extract of underground tuber of Dioscorea alata. Pharm Biol 54(8):1474–1482. https://doi.org/10.3109/13880209.2015.1104702.
Javed M, Saleem A, Akhtar MF (2023) Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats. Inflammopharmacology 31(4):1951–1966. https://doi.org/10.1007/s10787-023-01244-7.
Dunleavy KA, Raffals LE, Camilleri M (2023) Intestinal barrier dysfunction in inflammatory bowel disease: underpinning pathogenesis and therapeutics. Dig Dis Sci 68(12):4306–4320. https://doi.org/10.1007/s10620-023-08122-w.
Neurath MF, Artis D, Becker C (2025) The intestinal barrier: a pivotal role in health, inflammation and cancer. Lancet Gastroenterol Hepatol 10(6):573–592. https://doi.org/10.1016/S2468-1253(24)00390-X.
Alhazmi HA, Najmi A, Javed SA, Sultana SA, Bratty M, Makeen HA, Meraya AM, Ahsan W, Mohan S, Taha MME, Khalid A (2021) Medicinal plants and isolated molecules demonstrating immunomodulation activity as potential alternative therapies for viral diseases including COVID-19. Front Immunol 12:637553. https://doi.org/10.3389/fimmu.2021.637553.
Prajapati KK, Pandey V, Pandey R, Pandey VN (2025) A way forward in drug discovery and antimicrobial activities of Dioscorea L. species: a review. Int J Plant Env 11(1):20–33. https://doi.org/10.18811/ijpen.v11i01.00.
Mondal HK, Anisuzzman M, Hasan MM, Basiar MA, Sara M, Bairagi RD, Hossain MG (2025) Potential antioxidant, cytotoxic and antimicrobial activity of edible plant Dioscorea alata L. (leaves and stems). J Med Nat Prod 2(2):1–7. https://doi.org/10.53941/jmnp.2025.100013.
Mahmad N, Taha RM, Othman R, Abdullah S, Anuar N, Elias H, Rawi N (2018) Anthocyanin as potential source for antimicrobial activity in Clitoria ternatea L. and Dioscorea alata L. Pigm Resin Technol 47(6):490–495. https://doi.org/10.1108/PRT-11-2016-0109. (PMID: 10.1108/PRT-11-2016-0109)
Pugazhendhi S, Sathya P, Palanisamy PK, Gopalakrishnan R (2016) Synthesis of silver nanoparticles through green approach using Dioscorea alata and their characterization on antibacterial activities and optical limiting behavior. J Photochem Photobiol B Biol 159:155–160. https://doi.org/10.1016/j.jphotobiol.2016.03.043.
Saini T, Sharma S, Dash KK, Sandhu R, Dadwal V, Shams R, Pandey VK (2025) Role of bioactive phytochemicals in plant seeds and leaves for diabetes control and prevention: a comprehensive review. Phytochem Rev 24:5083–5108. https://doi.org/10.1007/s11101-025-10065-1.
Makiyah SNN, Kita M, Setyawati I, Tasminatun S (2022) Dioscorea alata L. tubers improve diabetes through anti-hyperglycemia, anti-inflammation, ameliorate insulin resistance and mitochondrial dysfunction. Indones Biomed J 14(4):365 − 75. https://doi.org/10.18585/inabj.v14i4.1966.
Maithili V, Dhanabal SP, Mahendran S, Vadivelan R (2011) Antidiabetic activity of ethanolic extract of tubers of Dioscorea alata in alloxan induced diabetic rats. Indian J pharmacol 43(4):455–459. https://doi.org/10.4103/0253-7613.83121.
Singh VP, Bali A, Singh N, Jaggi AS (2014) Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol 18(1):1–14. https://doi.org/10.4196/kjpp.2014.18.1.1.
Peng KY, Horng LY, Sung HC, Huang HC, Wu RT (2011) Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential botanical drug. Metab Clin Exp 60(6):888–892. https://doi.org/10.1016/j.metabol.2010.08.009.
Zhou YJ, Wang JH, Zhang J (2006) Hepatocyte growth factor protects human endothelial cells against advanced glycation end products-induced apoptosis. Biochem Biophys Res Commun 344(2):658–666. https://doi.org/10.1016/j.bbrc.2006.03.167.
Ampofo D, Agbenorhevi JK, Firempong CK, Adu-Kwarteng E (2020) Glycemic index of different varieties of yam as influenced by boiling, frying and roasting. Food Sci Nutr 9(2):1106–1111. https://doi.org/10.1002/fsn3.2087.
Amin KR, Uddin MG, Rashid MMO, Sharmin T (2018) New insight in neuropharmacological activities of Dioscorea alata. Discov Phytomed 5(1):1–6. https://doi.org/10.15562/phytomedicine.2018.52.
Das A, Chaudhuri D, Ghate NB, Chatterjee A, Mandal N (2014) Phytochemical analysis, antioxidant and anticancer potential of leaf extracts from edible greater yam, Dioscorea alata L, from North-East India. Int J Phytopharmacol 5(2):109–119.
Harington KJ, Syrigos KN (2000) The role of E-cadherin-catenin complex: more than an intercellular glue. Ann Surg Oncol 7:783–788. https://doi.org/10.1007/s10434-000-0783-5.
Hsu FL, Lin YH, Lee MH, Lin CL, Hou WC (2002) Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No.1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities. J Agric Food Chem 50(21):6109–6113. https://doi.org/10.1021/jf0203287.
Lin YS, Lu YL, Wang GJ, Liang HJ, Hou WC (2014) Vasorelaxing and antihypertensive activities of synthesized peptides derived from computer-aided simulation of pepsin hydrolysis of yam dioscorin. Bot Stud 55:49. https://doi.org/10.1186/s40529-014-0049-3.
Bhatnagar A, Kekatpure AL (2022) Postmenopausal osteoporosis: a literature review. Cureus 14(9):e29367. https://doi.org/10.7759/cureus.29367.
Song C, Ma Y, Wang Y, Li P, Chen Y, Liu H, Zhang Z (2023) Diosgenin reduces bone loss through the regulation of gut microbiota in ovariectomized rats. Gene 869:147383. https://doi.org/10.1016/j.gene.2023.147383.
Cheng WY, Kuo YH, Huang CJ (2007) Isolation and identification of novel estrogenic compounds in yam tuber (Dioscorea alata Cv. Tainung No. 2). J Agric Food Chem 55(18):7350–7358. https://doi.org/10.1021/jf0711690.
Wu WH, Liu LY, Chung CJ, Jou HJ, Wang TA (2005) Estrogenic effect of yam ingestion in healthy postmenopausal women. J Am Coll Nutr 24(4):235 − 43. https://doi.org/10.1080/07315724.2005.10719470.
Chen CT, Wang ZH, Hsu CC, Lin HH, Chen JH (2017) Taiwanese and Japanese yam (Dioscorea spp.) extracts attenuate doxorubicin-induced cardiotoxicity in mice. J Food Drug Anal 25(4):872–880. https://doi.org/10.1016/j.jfda.2016.09.002.
Chen CT, Wang ZH, Hsu CC, Lin HH, Chen JH (2015) In vivo protective effects of diosgenin against doxorubicin-induced cardiotoxicity. Nutrients 7(6):4938–4954. https://doi.org/10.3390/nu7064938.
Shanmugam G, Mohankumar A, Kalaiselvi D, Thiruppathi G, Nivitha S, Sundararaj P (2018) Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathways. Biomed Pharmacother 102:812–822. https://doi.org/10.1016/j.biopha.2018.03.128.
Ekimova IV, Plaksina DV, Pastukhov YF, Lapshina KV, Lazarev VF, Mikhaylova ER, Polonik SG, Pani B, Margulis BA, Guzhova IV, Nudler E (2018) New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson’s disease. Exp Neurol 306:199–208. https://doi.org/10.1016/j.expneurol.2018.04.012.
Li T, Teng H, An F, Huang Q, Chen L, Song H (2019) Beneficial effects of purple yam (Dioscorea alata L.) resistant starch on hyperlipidemia in high-fat-fed hamsters. Food Funct 10(5):2642–2650. https://doi.org/10.1039/c8fo02502a.
Khan R, Upaganlawar AB, Upasani C (2014) Protective effects of Dioscorea alata L. in aniline exposure-induced spleen toxicity in rats. Toxicol Int 21(3):294–299. https://doi.org/10.4103/0971-6580.155371.
Chang SJ, Lee YC, Liu SY, Chang TW (2004) Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats. J Agric Food Chem 52(6):1720–1725. https://doi.org/10.1021/jf0345954.
Hsu CC, Kuo HC, Huang KE (2017) The effects of phytosterols extracted from Dioscorea alata on the antioxidant activity, plasma lipids and hematological profiles in Taiwanese menopausal women. Nutrients 9(12):1320. https://doi.org/10.3390/nu9121320.
Hsu CC, Kuo HC, Chang SY, Wu TC, Huang KE (2011) The assessment of efficacy of Dioscorea alata for menopausal symptom treatment in Taiwanese women. Climacteric 14(1):132–139. https://doi.org/10.3109/13697137.2010.498594.
Logan K, Nwokocha C, Asemota H, Gray W (2024) Characterization of ACE inhibitory activity in Dioscorea alata and its implication as a natural antihypertensive extract. J Ethnopharmacol 319(2):117221. https://doi.org/10.1016/j.jep.2023.117221.
Contributed Indexing: Keywords: Dioscorea alata; Anticancer; Nutraceuticals; Pharmacological potential; Purple yam
Substance Nomenclature: 0 (Antioxidants)
0 (Plant Extracts)
0 (Anti-Inflammatory Agents)
0 (Phytochemicals)
0 (Hypoglycemic Agents)
0 (Saponins)
0 (Anthocyanins)
Entry Date(s): Date Created: 20260606 Date Completed: 20260610 Latest Revision: 20260710
Update Code: 20260711
DOI: 10.1007/s11130-026-01525-w
PMID: 42250036
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-9104
DOI:10.1007/s11130-026-01525-w