Academic Journal
Prenatal Diagnosis and Novel Therapeutics in Treatment of Genetic Conditions: Challenges and Opportunities.
| Τίτλος: | Prenatal Diagnosis and Novel Therapeutics in Treatment of Genetic Conditions: Challenges and Opportunities. |
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| Συγγραφείς: | Talati AN; Maternal Fetal Medicine & Reproductive Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: asha_talati@med.unc.edu., Jones M; Maternal Fetal Medicine & Reproductive Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hardisty EE; Maternal Fetal Medicine & Reproductive Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Michie M; Department of Bioethics, Case Western Reserve University School Of Medicine, Cleveland, Ohio., Allyse MA; Department of Bioethics, Case Western Reserve University School Of Medicine, Cleveland, Ohio., Vora NL; Maternal Fetal Medicine & Reproductive Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. |
| Πηγή: | Clinical therapeutics [Clin Ther] 2026 Jul; Vol. 48 (7), pp. 583-587. Date of Electronic Publication: 2026 Jun 06. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 7706726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-114X (Electronic) Linking ISSN: 01492918 NLM ISO Abbreviation: Clin Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1998- : Belle Mead, NJ, : Excerpta Medica Original Publication: Princeton, N. J., Excerpta Medica. |
| Ιατρικοί όροι (MeSH): | Prenatal Diagnosis*/ethics , Prenatal Diagnosis*/methods , Genetic Therapy*/methods , Genetic Therapy*/ethics , Genetic Diseases, Inborn*/diagnosis , Genetic Diseases, Inborn*/therapy , Genetic Diseases, Inborn*/genetics, Humans ; Pregnancy ; Female ; United States ; Genetic Counseling ; Genetic Testing |
| Περίληψη: | Therapeutic options for genetic conditions are rapidly expanding, including options for immediate postnatal therapy or in utero therapy. Many patient- and health care system-related factors influence access to and success of these therapies. At the most basic level, access to in utero therapies or immediate neonatal treatment is directly dependent upon access to prenatal counseling and diagnosis.1 As prenatal and postnatal diagnostic and therapeutic options continue to advance, the gaps in existing infrastructure for such specialized care delivery in the United States demand scrutiny. The purpose of this article is threefold. First, we will provide a general overview of the evolving landscape of prenatal diagnostic and therapeutic technologies. Second, we will review existing challenges to early, precise prenatal diagnosis and subsequent access to novel therapies and identify current ethical challenges that arise from introducing advancing technologies into the existing prenatal diagnostic health care structure. Finally, we will highlight opportunities to strengthen the existing US health care scaffolding to better incorporate novel therapeutics as they become more readily available. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest ANT receives research support from the National Institutes of Health (NIH), Billion to One, and The Greenwall Foundation. NLV receives research support from the National Institutes of Health and has received supplies in kind from Illumina. EE has no conflicts of interest. MEJ has no conflicts of interest. MA receives research support from the National Institutes of Health. MM receives research support from the National Institutes of Health. |
| Contributed Indexing: | Keywords: Ethics; Prenatal diagnosis; Reproductive genetics; Therapeutics |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260612 Latest Revision: 20260612 |
| Update Code: | 20260613 |
| DOI: | 10.1016/j.clinthera.2026.05.019 |
| PMID: | 42248756 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-114X |
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| DOI: | 10.1016/j.clinthera.2026.05.019 |