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Epilepsy as a predictor of subjective memory and executive dysfunction in American children and adults, with sleep as a relevant factor.

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Τίτλος: Epilepsy as a predictor of subjective memory and executive dysfunction in American children and adults, with sleep as a relevant factor.
Συγγραφείς: Wallace DA; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address: Danielle.Wallace2@emory.edu., Pedersen NP; Department of Neurology, University of California, Davis, CA, USA; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA. Electronic address: nppedersen@health.ucdavis.edu., Drane DL; Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA; Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: ddrane@emory.edu.
Πηγή: Epilepsy & behavior : E&B [Epilepsy Behav] 2026 Oct; Vol. 183, pp. 111139. Date of Electronic Publication: 2026 Jun 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
Imprint Name(s): Original Publication: San Diego, CA : Academic Press, c2000-
Ιατρικοί όροι (MeSH): Epilepsy*/complications , Epilepsy*/psychology , Epilepsy*/epidemiology , Executive Function*/physiology , Memory Disorders*/epidemiology , Memory Disorders*/etiology , Sleep Wake Disorders*/epidemiology , Sleep*/physiology, United States/epidemiology ; Humans ; Female ; Male ; Child ; Cross-Sectional Studies ; Adolescent ; Adult ; Young Adult ; Middle Aged
Περίληψη: People with epilepsy (PWE), including adults with epilepsy (AWE) and children with epilepsy (CWE), may experience problems with attention and memory. We hypothesized that epilepsy and sleep disturbances are associated with subjective memory and executive dysfunction. Using cross-sectional investigation of two nationally-representative U.S. surveys, the 2021-2023 National Health Interview Survey (NHIS) and the 2016-2023 National Survey of Children's Health (NSCH), we tested if subjective concentration or memory difficulty differed between children or adults with (n = 2675 children; n = 1570 adults) and without (n = 217,579 children; n = 84,763 adults) epilepsy. Analyses examined epilepsy (comparisons of no epilepsy, inactive epilepsy, and active epilepsy) as a predictor of memory, concentration, or decision-making difficulties. Data were analyzed in survey-weighted adjusted logistic regression models. Exploratory analyses evaluated seizure frequency, sleep health, physical activity, depression, and anxiety, as well as socialization in children. CWE had > 7 times higher odds of subjective memory, concentration, or decision-making difficulty compared to children without epilepsy (ORadj = 7.3; 95%CI: 6.21, 8.56; p < 0.001), and AWE had > 3.5 times higher odds of memory or concentration difficulty compared to people without epilepsy (ORadj = 3.7; 95%CI: 3.2, 4.2; p < 0.001). Odds were higher for PWE with active epilepsy. Reported memory or concentration difficulty were associated with worse sleep health in both AWE and CWE (p < 0.05). This large epidemiological study evaluated the prevalence of memory and executive dysfunction among 4,245 PWE, highlighting the ubiquity of memory and attention complaints, regardless of age or disease status. Memory and attention difficulties, particularly among CWE, may be an important factor in epilepsy-related disparities.
(Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Grant Information: R01 NS144894 United States NS NINDS NIH HHS; R01 NS147124 United States NS NINDS NIH HHS; R01 NS088748 United States NS NINDS NIH HHS; P30 ES019776 United States ES NIEHS NIH HHS; R00 HL166700 United States HL NHLBI NIH HHS
Contributed Indexing: Keywords: Epilepsy; Executive function; Memory; Pediatric; Public health; Sleep
Entry Date(s): Date Created: 20260605 Date Completed: 20260731 Latest Revision: 20260923
Update Code: 20260923
PubMed Central ID: PMC13392985
DOI: 10.1016/j.yebeh.2026.111139
PMID: 42247785
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1525-5069
DOI:10.1016/j.yebeh.2026.111139