Academic Journal
Immune complex-mediated membranoproliferative glomerulonephritis following scabies infestation in a child: a rare association.
| Τίτλος: | Immune complex-mediated membranoproliferative glomerulonephritis following scabies infestation in a child: a rare association. |
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| Συγγραφείς: | Prakash TS; Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India., Kamat N; Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India., Janardhanan JJ; Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India. |
| Πηγή: | Journal of nephrology [J Nephrol] 2026 Aug 28; Vol. 39 (5), pp. 1063-1067. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: England NLM ID: 9012268 Publication Model: Print Cited Medium: Internet ISSN: 1724-6059 (Electronic) Linking ISSN: 11218428 NLM ISO Abbreviation: J Nephrol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2014- : Heidelberg : Springer Original Publication: Rome : Acta Medica |
| Ιατρικοί όροι (MeSH): | Antigen-Antibody Complex*/immunology , Glomerulonephritis, Membranoproliferative*/diagnosis , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/immunology , Glomerulonephritis, Membranoproliferative*/parasitology , Scabies*/complications , Scabies*/diagnosis , Scabies*/drug therapy , Scabies*/parasitology, Antiparasitic Agents/administration & dosage ; Cyclophosphamide/administration & dosage ; Immunosuppressive Agents/administration & dosage ; Ivermectin/administration & dosage ; Permethrin/administration & dosage ; Adolescent ; Animals ; Humans ; Male ; Biopsy ; Remission Induction ; Sarcoptes scabiei ; Treatment Outcome |
| Περίληψη: | Scabies, caused by Sarcoptes scabiei var. hominis, is a common parasitic infestation in tropical regions. Although primarily dermatological, it can rarely trigger systemic complications such as immune complex-mediated membranoproliferative glomerulonephritis (MPGN). A 14-year-old boy presented with bilateral pedal edema, facial puffiness, and reddish urine for one week. Examination revealed pruritic papular lesions over the interdigital spaces, and microscopy confirmed Sarcoptes scabiei infestation. Investigations showed nephrotic-range proteinuria (4.9 g/day), microscopic hematuria, and normal complement levels. Kidney biopsy demonstrated immune complex-mediated MPGN with crescent formation. The patient was treated with topical 5% permethrin and oral ivermectin for scabies, followed by corticosteroid pulses and monthly cyclophosphamide. Complete clinical and biochemical remission occurred within six months. This case highlights scabies as a potential trigger for immune complex-mediated glomerulonephritis through chronic antigenic stimulation. Scabies-associated MPGN, though rare, should be recognized as a treatable cause of immune-mediated kidney injury. Early diagnosis and combined anti-parasitic and immunosuppressive therapy can achieve complete remission. (© The Author(s) 2026. Published by Oxford University Press on behalf of Societa Italiana Nefrologia/Italian Society of Nephrology; Society ownership. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Competing Interests: | Conflicts of interest: None declared. |
| Contributed Indexing: | Keywords: immune complex; infection-associated glomerulonephritis; membranoproliferative glomerulonephritis; scabies |
| Substance Nomenclature: | 0 (Antigen-Antibody Complex) 0 (Antiparasitic Agents) 8N3DW7272P (Cyclophosphamide) 0 (Immunosuppressive Agents) 70288-86-7 (Ivermectin) 509F88P9SZ (Permethrin) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260828 Latest Revision: 20260916 |
| Update Code: | 20260917 |
| DOI: | 10.1093/joneph/aajag062 |
| PMID: | 42246603 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1724-6059 |
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| DOI: | 10.1093/joneph/aajag062 |