Academic Journal
Valorization of Sea Buckthorn (Hippophae rhamnocaides L.) Leaves: Polyphenol-Rich Extract Targeting Helicobacter pylori Virulence and Gastric Mucosal Homeostasis.
| Title: | Valorization of Sea Buckthorn (Hippophae rhamnocaides L.) Leaves: Polyphenol-Rich Extract Targeting Helicobacter pylori Virulence and Gastric Mucosal Homeostasis. |
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| Authors: | Chen H; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China., Zhang C; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China., Zou Y; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China., Feng Z; Lunan Pharmaceutical Group Co., Ltd, Linyi 276000, Shandong, China., Yao M; School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China., Peng C; Discipline of Chinese and Western Integrative Medicine, College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China., Chen Q; Institute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore. |
| Source: | Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jun 17; Vol. 74 (23), pp. 17980-18001. Date of Electronic Publication: 2026 Jun 05. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| MeSH Terms: | Helicobacter pylori*/drug effects , Helicobacter pylori*/pathogenicity , Helicobacter pylori*/physiology , Helicobacter pylori*/genetics , Hippophae*/chemistry , Plant Extracts*/administration & dosage , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Polyphenols*/administration & dosage , Polyphenols*/chemistry , Helicobacter Infections*/microbiology , Helicobacter Infections*/drug therapy , Helicobacter Infections*/immunology , Helicobacter Infections*/genetics , Helicobacter Infections*/metabolism , Gastric Mucosa*/microbiology , Gastric Mucosa*/drug effects , Gastric Mucosa*/immunology , Gastric Mucosa*/metabolism , Anti-Bacterial Agents*/administration & dosage , Anti-Bacterial Agents*/chemistry, Plant Leaves/chemistry ; Virulence/drug effects ; Homeostasis/drug effects ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/immunology ; Interleukin-1beta/genetics ; Interleukin-1beta/immunology ; Cytokines/genetics ; Cytokines/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Animals ; Mice ; Humans ; Female ; Male |
| Abstract: | Sea buckthorn (Hippophae rhamnoides L.) leaves are rich in polyphenols and exhibit potent activity against Helicobacter pylori. This study found that its extract demonstrates a dual mechanism of action, inhibiting bacterial virulence while protecting the gastric mucosa. For multidrug-resistant strains, the minimum inhibitory concentration (MIC) range of this extract was 0.08-0.64 mg/mL. At 0.32 mg/mL, it significantly suppressed H. pylori motility and urease activity by 72% and 56%, respectively. In an infected mouse model, the extract lowered gastric pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and promoted mucosal protection. Multiomics analysis reveals enhanced mucosal immunity and increased abundance of beneficial gastric microbiota (Ligilactobacillus and Akkermansia). As an agricultural byproduct, sea buckthorn leaf extract holds promise as a dietary supplement for managing H. pylori-associated gastropathy. |
| Contributed Indexing: | Keywords: Helicobacter pylori; anti-inflammatory; gastric microbiota; immunomodulation; phytochemical analyses; sea buckthorn leaf |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Polyphenols) 0 (Anti-Bacterial Agents) 0 (Tumor Necrosis Factor-alpha) 0 (Interleukin-1beta) 0 (Cytokines) 0 (Interleukin-6) |
| Entry Date(s): | Date Created: 20260605 Date Completed: 20260617 Latest Revision: 20260617 |
| Update Code: | 20260617 |
| DOI: | 10.1021/acs.jafc.6c02235 |
| PMID: | 42246387 |
| Database: | MEDLINE |
| ISSN: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.6c02235 |