Academic Journal
SeqBoard: a genomics-based data dashboard for comprehensive wastewater virome monitoring.
| Τίτλος: | SeqBoard: a genomics-based data dashboard for comprehensive wastewater virome monitoring. |
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| Συγγραφείς: | Bauer C; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States.; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Center for Spatial-temporal Modeling for Applications in Population Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Reger N; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States.; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Center for Spatial-temporal Modeling for Applications in Population Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Rustem HAL; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Tisza M; The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States., Triosi CL; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Management, Policy & Community Health, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, United States., Javornik Cregeen S; The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States., Ghobrial L; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States., Gitter A; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Environmental and Occupational Health Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Wu F; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Environmental and Occupational Health Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Surathu A; The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States., Deegan J; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States., Mena KD; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Environmental and Occupational Health Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Petrosino J; The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States., Boerwinkle E; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Hanson BM; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX 77030, United States., Maresso AW; Texas Epidemic Public Health Institute (TEPHI), Houston, TX 77030, United States.; The Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States.; TAILOR Labs, Baylor College of Medicine, Houston, TX 77030, United States. |
| Πηγή: | Journal of the American Medical Informatics Association : JAMIA [J Am Med Inform Assoc] 2026 Aug 01; Vol. 33 (8), pp. 1446-1456. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9430800 Publication Model: Print Cited Medium: Internet ISSN: 1527-974X (Electronic) Linking ISSN: 10675027 NLM ISO Abbreviation: J Am Med Inform Assoc Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2015- : Oxford : Oxford University Press Original Publication: Philadelphia, PA : Hanley & Belfus, c1993- |
| Ιατρικοί όροι (MeSH): | Wastewater*/virology , Dashboard Systems* , Genomics* , Virome*, Humans ; User-Computer Interface |
| Περίληψη: | Objectives: To develop the first public-facing dashboard that translates genomic sequencing data from wastewater into accessible and actionable community information concerning human pathogenic viruses, representing a shift to sequencing-based public health wastewater monitoring. Materials and Methods: We developed SeqBoard, a user-friendly dashboard that displays sequencing information from the total wastewater virome. The dashboard integrates diverse expertise and components, including data processing and analysis, visualization and management, security, and stakeholder engagement and feedback. We implemented a 3-tiered system for user interactions, customized to the general public, public health officials, and genomics experts. Results: SeqBoard provides an intuitive interface for presenting genomic information as species-specific trend lines, level indicators, and all-site aggregates. It translates complex sequencing data into public health insights, including reporting on dozens of viruses of concern with modules for detections, variant information, and genomic context. Discussion: The prevention of the next pandemic will require comprehensive pan-monitoring of deadly viruses and their evolution. Genomics-based dashboards will be essential for early detection of viral activity before significant clinical manifestation, thereby allowing public health systems to provide warnings, ready actions, and develop vaccines. Conclusion: SeqBoard shows that sequencing data can be translated into useful public health information, serving as a model for future sequencing-based pathogen dashboards. The dashboard is publicly available at https://tephi-ww.uth.edu/public-dashboard and represents the first publicly available dashboard providing pan viral genomic detection data for wastewater monitoring. (© The Author(s) 2026. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Grant Information: | UTHealth Houston Seed; U19 AI44297 United States NH NIH HHS; Anonymous Foundation; U19 AI144297 United States AI NIAID NIH HHS; Alkek Foundation Seed; S.B. 1780, 87th Legislature, 2021 Reg. Sess.; Baylor College of Medicine |
| Contributed Indexing: | Keywords: dashboard; metagenomics; public health; surveillance; wastewater monitoring |
| Substance Nomenclature: | 0 (Wastewater) |
| Entry Date(s): | Date Created: 20260604 Date Completed: 20260721 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13386005 |
| DOI: | 10.1093/jamia/ocag088 |
| PMID: | 42243631 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1527-974X |
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| DOI: | 10.1093/jamia/ocag088 |