Academic Journal
One-pot click synthesis of hybrid triazole-pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays.
| Τίτλος: | One-pot click synthesis of hybrid triazole-pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays. |
|---|---|
| Συγγραφείς: | Amariucai-Mantu D; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Marandis CG; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Diaconu D; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania., Antoci V; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania. vasilichia.antoci@uaic.ro., Mangalagiu II; Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bvd, Iasi, 700506, Romania. ionelm@uaic.ro. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Jun 05; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 05. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Triazoles*/chemistry , Click Chemistry*/methods , Polyphenols*/chemistry , Polyphenols*/pharmacology , Polyphenols*/chemical synthesis , Pyridines*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemical synthesis , Anti-Infective Agents*/chemistry, Gram-Negative Bacteria/drug effects ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemical synthesis ; Microbial Sensitivity Tests ; Ultrasonic Waves ; Green Chemistry Technology |
| Περίληψη: | In the present work, we describe an efficient, straightforward, and environmentally friendly method for synthesizing hybrid triazole-pyridine-functionalized polyphenol derivatives via a one-pot, three-component click reaction under ultrasound irradiation. The reactions are high-yielding (65-90%), require shorter reaction times, use lower solvent volumes, show notable acceleration, and involve lower energy consumption. Taking into account the 12 principles of green chemistry and the above considerations, the one-pot, three-component click reactions under US irradiation may be considered environmentally friendly. The green character of our one-pot three-component click reaction setup procedure under US irradiation is also confirmed by the green chemistry metrics Atom Economy, Environmental factor, and Process Mass Intensity, which have meaningful values in accord with the green chemistry principles. A notable influence of the halogen atom in the click reactions was observed; bromine derivatives are much more suitable for one-pot, three-component click reactions under US irradiation, with a fourfold yield increase. The preliminary antimicrobial assay reveals that some of the hybrid triazole-pyridine-functionalized polyphenol derivatives exhibit very good activity against Gram-positive bacteria (in the nanograms/mL range) and good activity against Gram-negative bacteria and fungi (in the micrograms/mL range). (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Antibacterial and antifungal activity; Environmentally friendly click reaction; Hybrid triazole-pyridine-functionalized polyphenols; One-pot-three component reaction; Ultrasound |
| Substance Nomenclature: | 0 (Triazoles) 0 (Polyphenols) 0 (Pyridines) 0 (Anti-Infective Agents) NH9L3PP67S (pyridine) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260604 Date Completed: 20260816 Latest Revision: 20260819 |
| Update Code: | 20260819 |
| PubMed Central ID: | PMC13478586 |
| DOI: | 10.1038/s41598-026-54643-5 |
| PMID: | 42243367 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-026-54643-5 |