Academic Journal
HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee.
| Τίτλος: | HLA matching in contemporary haematopoietic cell transplantation: Recommendations from the EBMT Practice Harmonisation and Guidelines Committee. |
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| Συγγραφείς: | Arrieta-Bolaños E; Institute for Experimental Cellular Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Lima ACM; Immunogenetics Institute (IGEN), Associação Fundo de Incentivo à Pesquisa, São Paulo; Histocompatibility Laboratory, Complexo Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil., Andreani M; Laboratory of Transplant Immunogenetics, Department of Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy., De Santis D; Department of Clinical Immunology, Path West, Perth, WA, Australia., Malard F; Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938 Centre de Recherche Saint-Antoine, Paris, France., Mayor NP; Anthony Nolan Research Institute, Royal Free Hospital, London, UK.; UCL Cancer Institute, University College London, London, UK., Mehta RS; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Meisel R; Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany., Pagliuca S; Department of Hematology, Nancy University Hospital & CNRS UMR7365 IMoPA, University of Lorraine, Vandoeuvre-lès-Nancy-France, Nancy, France., Petersdorf E; Division of Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, Washington; Department of Medicine, University of Washington, Seattle, USA., Piemontese S; Hematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Sacchi N; Italian Bone Marrow Donor Registry, EO Ospedali Galliera di Genova, Genoa, Italy., Santoro N; Hematology Unit, Department of Oncology and Hematology, Pescara Hospital, Pescara, Italy; Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti, Italy., Sanz J; Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia Departament de Medicina Universitat de Valencia, CIBERONC, Instituto Carlos III, Madrid, Spain., Schetelig J; Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.; DKMS Group, Dresden, Germany., Spellman SR; CIBMTR® (Center for International Blood and Marrow Transplant Research), NMDP, Minneapolis, MN, USA., Onida F; Co-Chair of the Practice Harmonisation and Guidelines Committee of the EBMT, Hematology & ASCT Unit, ASST Fatebenefratelli-Sacco, University of Milan, Milan, Italy., Sánchez-Ortega I; Secretary of the Practice Harmonisation and Guidelines Committee of EBMT EBMT Medical Officer, Executive Office, Barcelona, Spain., Mohty M; Service d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, Sorbonne Université, INSERM UMRs 938 Centre de Recherche Saint-Antoine, Paris, France., Yakoub-Agha I; Chair of the EBMT Practice Harmonisation and Guidelines Committee CHU de Lille, Univ Lille, INSERM U1286, Infinite, 59000, Lille, France., Fleischhauer K; Institute for Experimental Cellular Therapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Ruggeri A; Hematology and BMT Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. annalisaruggeri80@hotmail.com.; Co-Chair of the Practice Harmonisation and Guidelines Committee of EBMT and Chair of the CTIWP of EBMT, Paris, France. annalisaruggeri80@hotmail.com. |
| Πηγή: | Bone marrow transplantation [Bone Marrow Transplant] 2026 Aug; Vol. 61 (8), pp. 1015-1023. Date of Electronic Publication: 2026 Jun 02. |
| Τύπος έκδοσης: | Journal Article; Practice Guideline |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2003->: London : Nature Publishing Group Original Publication: Basingstoke, Hampshire : Scientific & Medical Division, Macmillan Press, c1986- |
| Ιατρικοί όροι (MeSH): | Hematopoietic Stem Cell Transplantation*/methods , Histocompatibility Testing*/methods , HLA Antigens*/immunology, Graft vs Host Disease/prevention & control ; Humans |
| Περίληψη: | HLA compatibility has been a cornerstone for safe and successful allogeneic haematopoietic cell transplantation (HCT), with human leukocyte antigen (HLA)-mismatched transplants consistently associated with inferior survival. However, recent advances in typing technologies, supportive care, and novel graft-versus-host disease (GvHD) prophylaxes have prompted the revisiting of HLA mismatch relevance in contemporary HCT. Within the framework of the 3rd Workshops of the Practice Harmonization & Guidelines Committee, the EBMT convened a group of experts in histocompatibility & immunogenetics, HCT immunobiology, and clinical HCT, to review the current state of the art and develop a set of consensus-based recommendations on the role of HLA in current HCT. The topics included technological aspects of HLA typing, the role of HLA mismatches in donor selection, and the detection and management of anti-HLA antibodies in HLA-mismatched transplantation. Moreover, the role of HLA matching relative to other non-HLA factors and in the context of novel GvHD prophylaxes, non-malignant disease, and pediatric populations was defined. Finally, the relevance of special models for HLA matching and of post-HCT monitoring of HLA-loss in malignant disease relapse was reviewed. The present document summarizes the expert consensus on these topics, to provide evidence-based recommendations for clinical decision-making. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: RSM reports Consultancy for OrcaBio and expert opinion for Lumanity. All other authors declare no competing interests. |
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| Substance Nomenclature: | 0 (HLA Antigens) |
| Entry Date(s): | Date Created: 20260602 Date Completed: 20260805 Latest Revision: 20260820 |
| Update Code: | 20260821 |
| PubMed Central ID: | PMC13437245 |
| DOI: | 10.1038/s41409-026-02922-0 |
| PMID: | 42230962 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1476-5365 |
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| DOI: | 10.1038/s41409-026-02922-0 |