Academic Journal
Investigating haemodynamic changes during vaginal delivery in low-risk pregnant women and the association between haemodynamic and adverse pregnancy outcomes: an ambispective cohort study protocol.
| Τίτλος: | Investigating haemodynamic changes during vaginal delivery in low-risk pregnant women and the association between haemodynamic and adverse pregnancy outcomes: an ambispective cohort study protocol. |
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| Συγγραφείς: | Chen C; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Guo D; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Zhou T; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Xu W; School of Public Health, Chongqing Medical University, Chongqing, China., Yang Y; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Tang Z; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Zhang H; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China., Wang L; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China yu.xinyang@cqmu.edu.cn 27454491@qq.com., Yu X; Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China yu.xinyang@cqmu.edu.cn 27454491@qq.com. |
| Πηγή: | BMJ open [BMJ Open] 2026 Jun 02; Vol. 16 (6), pp. e106885. Date of Electronic Publication: 2026 Jun 02. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BMJ Publishing Group Ltd, 2011- |
| Ιατρικοί όροι (MeSH): | Hemodynamics*/physiology , Labor, Obstetric*/physiology , Delivery, Obstetric* , Pregnancy Outcome* , Observational Studies as Topic*, Adult ; Female ; Humans ; Pregnancy ; China ; Cohort Studies ; Research Design |
| Περίληψη: | Introduction: The progressive adaptation of the maternal cardiovascular system throughout pregnancy is essential to maintaining adequate uteroplacental circulation and meeting maternal physiological demands. In recent years, maternal haemodynamic parameters have gained attention as useful indicators for screening and managing pregnancy, particularly for identifying women at high risk for complications and predicting adverse pregnancy outcomes. The aim of this study is to assess the trajectory of haemodynamic parameters during labour, establish reference ranges for different stages of labour and explore the association between haemodynamics and adverse pregnancy outcomes. Methods and Analysis: This is an ambispective observational cohort study conducted in a tertiary hospital in Chongqing, China. A total of 2800 pregnant women will be enrolled. After hospital admission and providing written informed consent, participants will complete a demographic questionnaire. Data collection will include maternal baseline characteristics, haemodynamic parameters at multiple stages of labour and maternal and newborn outcomes. These data will allow comprehensive analysis of haemodynamic changes during labour in women undergoing vaginal delivery. Ethics and Dissemination: This study has been approved by the Research Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (ethics approval number: 2024-406-01). Participation is voluntary and initiated only after obtaining written informed consent. The findings will be disseminated through presentations at national and international conferences and through publications in peer-reviewed scientific journals. Trial Registration Number: ChiCTR2500097643. (© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
| Contributed Indexing: | Keywords: Hemodynamics; Pregnancy; Sensitivity and Specificity |
| Entry Date(s): | Date Created: 20260602 Date Completed: 20260606 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13239657 |
| DOI: | 10.1136/bmjopen-2025-106885 |
| PMID: | 42229950 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2044-6055 |
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| DOI: | 10.1136/bmjopen-2025-106885 |