Academic Journal
PDA@Pt nanoparticles: Dual antiviral and anti-inflammatory effects against influenza A virus through multi-target mechanisms.
| Τίτλος: | PDA@Pt nanoparticles: Dual antiviral and anti-inflammatory effects against influenza A virus through multi-target mechanisms. |
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| Συγγραφείς: | Deng X; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China., Chen Z; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China., Yang S; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China., Chen Z; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China., Yang J; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China., Yang J; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: yj528@smu.edu.cn., Chen J; Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism and Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: jxchen@smu.edu.cn. |
| Πηγή: | Biomaterials advances [Biomater Adv] 2026 Nov; Vol. 188, pp. 214949. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Amsterdam] : Elsevier B.V., [2022]- |
| Ιατρικοί όροι (MeSH): | Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Polymers*/chemistry , Polymers*/pharmacology , Indoles*/chemistry , Indoles*/pharmacology , Influenza A virus*/drug effects , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Platinum*/chemistry , Platinum*/pharmacology , Metal Nanoparticles*/chemistry, Reactive Oxygen Species/metabolism ; Virus Replication/drug effects ; Nanoparticles/chemistry ; Animals ; Dogs ; Humans ; Madin Darby Canine Kidney Cells |
| Περίληψη: | Influenza A virus (IAV) infection can lead to severe complications, including acute lung injury, driven by hypoxia, excessive reactive oxygen species (ROS), and cytokine release syndrome (CRS). To address the limitations of current therapies, such as insufficient antiviral efficacy and poor CRS control, we developed polydopamine-platinum core-shell nanoparticles (PDA@Pt) with dual antiviral and anti-inflammatory functions. The PDA core scavenges ROS to alleviate CRS and disrupts viral replication, while the Pt shell inhibits viral entry and catalyzes the decomposition of H (Copyright © 2026. Published by Elsevier B.V.) |
| Competing Interests: | Declaration of competing interest The authors declare no conflict of interest. |
| Contributed Indexing: | Keywords: Anti-inflammatory; Antiviral; Core-shell structure; Influenza A virus; Platinum nanoparticles; Polydopamine |
| Substance Nomenclature: | 0 (Antiviral Agents) 0 (Polymers) 0 (Indoles) 0 (Anti-Inflammatory Agents) 49DFR088MY (Platinum) 0 (Reactive Oxygen Species) 0 (polydopamine) |
| Entry Date(s): | Date Created: 20260602 Date Completed: 20260731 Latest Revision: 20260731 |
| Update Code: | 20260801 |
| DOI: | 10.1016/j.bioadv.2026.214949 |
| PMID: | 42229293 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2772-9508 |
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| DOI: | 10.1016/j.bioadv.2026.214949 |