Academic Journal
The incremental yield of CMA over karyotype in fetal ventriculomegaly: a systematic review and meta-analysis.
| Τίτλος: | The incremental yield of CMA over karyotype in fetal ventriculomegaly: a systematic review and meta-analysis. |
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| Συγγραφείς: | Sapantzoglou I; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece. ioakeimsap@med.uoa.gr., Fasoulakis Z; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Tasias K; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Rouvali A; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Pegkou A; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Theodora M; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Daskalakis G; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece., Antsaklis P; 1St Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven. 2-4, Lourou Str, 11528, Athens-Greece, PC, Greece. |
| Πηγή: | Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2026 Jun 02; Vol. 313 (1). Date of Electronic Publication: 2026 Jun 02. |
| Τύπος έκδοσης: | Journal Article; Systematic Review; Meta-Analysis |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8710213 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0711 (Electronic) Linking ISSN: 09320067 NLM ISO Abbreviation: Arch Gynecol Obstet Subsets: MEDLINE |
| Imprint Name(s): | Publication: Berlin : Springer Verlag Original Publication: München : Springer International, c1987- |
| Ιατρικοί όροι (MeSH): | Hydrocephalus*/genetics , Hydrocephalus*/diagnosis , Prenatal Diagnosis*/methods , Karyotyping* , Microarray Analysis*, Humans ; Female ; Pregnancy ; Karyotype |
| Περίληψη: | Objective: The main objective of our study was to conduct a systematic literature review and a meta-analysis to evaluate the incremental yield of chromosomal microarray analysis compared to karyotyping in cases of fetal ventriculomegaly. Methods: Our review was designed according to the PRISMA guidelines. It included all observational studies that reported the results of CMA testing in fetuses diagnosed with ventriculomegaly (both isolated and non-isolated),in fetuses with isolated ventriculomegaly, in fetuses with non-isolated ventriculomegaly, and in fetuses with mild isolated ventriculomegaly. Results: 16 studies were included with a total of 2137 cases of affected fetuses that met the inclusion criteria for analysis. Combined data from these studies revealed an overall incremental yield of CMA over karyotyping of 7% (95% CI 4-10%) in cases with ventriculomegaly, 4% (95% CI 2-6%) in isolated cases, 10% (95% CI 6-16%) in non-isolated cases, and 2% (95% CI 1-4%) in mild isolated cases. Conclusions: Our findings may be useful in clinical practice to guide management options and the counseling of the couples to individualize patient care and facilitate clinicians when they come across such a common clinical entity. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interests: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: Ethical approval was waived by the local Ethics Committee due to the nature and design of the study. Consent to participate: Not applicable or needed for this study. Consent to publish: Not applicable or needed for this study. |
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| Contributed Indexing: | Keywords: Array CGH; CMA; Fetal ventriculomegaly; Karyotype; VM |
| Entry Date(s): | Date Created: 20260602 Date Completed: 20260806 Latest Revision: 20260824 |
| Update Code: | 20260824 |
| PubMed Central ID: | PMC13442320 |
| DOI: | 10.1007/s00404-026-08470-8 |
| PMID: | 42228177 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-0711 |
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| DOI: | 10.1007/s00404-026-08470-8 |