Academic Journal
Structural diversity, natural occurrence, synthesis, and bioactivities of naphthopyrones.
| Τίτλος: | Structural diversity, natural occurrence, synthesis, and bioactivities of naphthopyrones. |
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| Συγγραφείς: | Cong M; Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China., Shen S; Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China., Pang X; Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; Sanya Institute of Ocean Eco-Environmental Engineering, Sanya, 572000, China., Liu Y; Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China; Sanya Institute of Ocean Eco-Environmental Engineering, Sanya, 572000, China. Electronic address: yonghongliu@scsio.ac.cn., Wang J; Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, China; Sanya Institute of Ocean Eco-Environmental Engineering, Sanya, 572000, China. Electronic address: wangjunfeng@scsio.ac.cn. |
| Πηγή: | Phytochemistry [Phytochemistry] 2026 Oct; Vol. 250, pp. 114985. Date of Electronic Publication: 2026 May 30. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Naphthalenes*/chemistry , Naphthalenes*/pharmacology , Naphthalenes*/chemical synthesis , Biological Products*/chemistry , Biological Products*/pharmacology , Biological Products*/chemical synthesis , Pyrones*/chemistry , Pyrones*/pharmacology , Pyrones*/chemical synthesis, Molecular Structure ; Humans ; Animals |
| Περίληψη: | Naphthopyrones (NPs) are a class of heterocyclic molecules formed by the fusion of naphthalene and pyran ring. They are widely distributed in microorganisms, plants, and marine organisms, which have become a research focus in medicinal and synthetic chemistry due to their unique rigid skeleton, diverse biological activities, and controllable axial chirality. In recent years, with the innovation of synthesis technology and the in-depth analysis of the mechanism of action, the research on NPs has expanded from natural products discovery to functional oriented molecular design and application exploration. This article systematically reviews the structural diversity, pharmacological activity, and synthesis strategies of naphthopyrones compound. This is the first comprehensive review on NPs, which summarizing 226 compounds during the period of 1937 to December 2025, covering 161 articles laying the foundation for the development and utilization of NPs in the future. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Bioactivities; Biosynthesis; Naphthopyrones; Structural diversity; Synthesis |
| Substance Nomenclature: | 0 (Naphthalenes) 0 (Biological Products) 0 (Pyrones) |
| Entry Date(s): | Date Created: 20260530 Date Completed: 20260719 Latest Revision: 20260719 |
| Update Code: | 20260720 |
| DOI: | 10.1016/j.phytochem.2026.114985 |
| PMID: | 42217555 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-3700 |
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| DOI: | 10.1016/j.phytochem.2026.114985 |