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4-Mercaptobenzenesulfonic acid-functionalized SiO2@Au nanoshells for specific enrichment and SALDI-MS detection of quaternary ammonium compounds.

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Τίτλος: 4-Mercaptobenzenesulfonic acid-functionalized SiO2@Au nanoshells for specific enrichment and SALDI-MS detection of quaternary ammonium compounds.
Συγγραφείς: Du M; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China; College of Natural Resources and Environment, South China Agricultural University, Guangzhou, 510642, China., Chen X; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Sun Y; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Hu J; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Wen W; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China., Xu H; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address: hhxu@scau.edu.cn., Yin Z; Institute of Advanced Light Source Facilities, Shenzhen 518107, China. Electronic address: yinzhibin@mail.iasf.ac.cn., Wu X; National Key Laboratory of Green Pesticide, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, College of Plant Protection, South China Agricultural University, Guangzhou 510642, China. Electronic address: wuxz@scau.edu.cn.
Πηγή: Journal of chromatography. A [J Chromatogr A] 2026 Aug 30; Vol. 1783, pp. 467136. Date of Electronic Publication: 2026 May 25.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE
Imprint Name(s): Original Publication: Amsterdam ; New York : Elsevier, 1993-
Ιατρικοί όροι (MeSH): Silicon Dioxide*/chemistry , Quaternary Ammonium Compounds*/analysis , Quaternary Ammonium Compounds*/isolation & purification , Quaternary Ammonium Compounds*/chemistry , Gold*/chemistry , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*/methods , Sulfhydryl Compounds*/chemistry, Nanocomposites/chemistry ; Adsorption ; Limit of Detection ; Reproducibility of Results ; Hydrogen-Ion Concentration ; Linear Models ; Benzoates
Περίληψη: The widespread use and persistence of quaternary ammonium compounds (QACs) in food environments raise concerns about their detection at trace levels in complex matrices. In this study, we developed a negatively charged 4-mercaptobenzenesulfonic acid functionalized SiO2@Au core-shell nanocomposite (MBSA-SiO2@Au) that serves as both a selective adsorbent and an efficient surface-assisted laser desorption/ionization (SALDI) matrix. The sulfonate modified gold shell provides a stable negative surface potential to promote electrostatic interactions with cationic QACs, and their plasmonic properties synergistically enhance laser energy absorption and ionization efficiency. Critical enrichment parameters, including adsorbent amount, solution pH, adsorption time, and redispersion volume, were optimized. The optimized method achieved limits of detection of 0.5 ng/mL for paraquat (PQ), dodecyltrimethylammonium chloride (DTAC), and didodecyldimethylammonium chloride (DDAC), and 1.5 ng/mL for dodecyldimethylbenzylammonium chloride (DBAC), with excellent linearity (R2 ≥ 0.9843), achieving an enrichment factor of approximately 33.3, and a 20- to 40-fold sensitivity enhancement after enrichment. Application to real food samples, including white radish, carrot, and potato, revealed no detectable QAC residues and satisfactory recoveries ranging from 87.0 to 108.8%. The bifunctional MBSA-SiO2@Au-based SALDI platform minimizes organic solvent consumption and offers a rapid, green, and sensitive approach for monitoring QACs in food safety applications.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: MBSA-SiO(2)@Au; Mass spectrometry; Quaternary ammonium compounds; Specific enrichment; Surface-assisted laser desorption/ionization
Substance Nomenclature: 7631-86-9 (Silicon Dioxide)
0 (Quaternary Ammonium Compounds)
7440-57-5 (Gold)
0 (Sulfhydryl Compounds)
1074-36-8 (4-mercaptobenzoate)
0 (Benzoates)
Entry Date(s): Date Created: 20260530 Date Completed: 20260629 Latest Revision: 20260629
Update Code: 20260630
DOI: 10.1016/j.chroma.2026.467136
PMID: 42217394
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-3778
DOI:10.1016/j.chroma.2026.467136