Academic Journal
Genetic associations between polyunsaturated fatty acids and alopecia areata.
| Τίτλος: | Genetic associations between polyunsaturated fatty acids and alopecia areata. |
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| Συγγραφείς: | Liu Q; Department of Plastic Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Cai Y; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li W; Department of Plastic Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Shi W; Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Yu L; Department of Plastic Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China., Cai X; Department of Plastic Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China. |
| Πηγή: | Medicine [Medicine (Baltimore)] 2026 May 29; Vol. 105 (22), pp. e49058. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
| Ιατρικοί όροι (MeSH): | Alopecia Areata*/blood , Alopecia Areata*/ethnology , Alopecia Areata*/genetics , Fatty Acids, Unsaturated*/blood , Fatty Acids, Unsaturated*/genetics, Docosahexaenoic Acids/blood ; Fatty Acids, Omega-3/blood ; Fatty Acids, Omega-6/blood ; Genetic Predisposition to Disease/ethnology ; Genetic Predisposition to Disease/genetics ; Linoleic Acid/blood ; White People/genetics ; Humans ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide |
| Περίληψη: | The influence of circulating polyunsaturated fatty acids (PUFAs) on alopecia areata (AA) development remains poorly understood, with inconsistent results reported. Our study aims to evaluate their causal associations using the bidirectional Mendelian randomization method. European ancestry genome-wide association studies were used to analyze the genetic associations between PUFAs and AA (n = 211,428). Sample sizes for PUFAs were 13,527, 13,506, 114,999, 7818, and 13,549 for plasma linoleic acid (LA), omega-6, omega-3, docosahexaenoic acid (DHA), and PUFAs other than 18:2 (otPUFA), respectively. The causal associations were primarily determined by the inverse variance weighted (IVW) method. Circulating omega-6 (IVW odds ratio [OR] = 1.64, 95% confidence interval [CI] = 1.15-2.33, P = .0059) and LA (IVW OR = 1.49, 95% CI = 1.05-2.13, P = .0257) were positively associated with AA risk. Conversely, AA was negatively correlated with circulating DHA (IVW OR = 0.99, 95% CI = 0.99-1.00, P = .0324). Elevated circulating omega-6 and LA are correlated with an increased AA risk. Furthermore, AA was negatively associated with circulating DHA. These findings provide insights into the potential biological mechanisms underlying the development of AA, offering potential implications for dietary recommendations and treatment options. (Copyright © 2026 the Author(s). Published by Wolters Kluwer Health, Inc.) |
| Competing Interests: | The authors have no funding and conflicts of interest to disclose. |
| References: | Chu SY, Chen YJ, Tseng WC, et al. Psychiatric comorbidities in patients with alopecia areata in Taiwan: a case-control study. Br J Dermatol. 2012;166:525–31. Zhou C, Li X, Wang C, Zhang J. Alopecia areata: an update on etiopathogenesis, diagnosis, and management. Clin Rev Allergy Immunol. 2021;61:403–23. Ito T, Tokura Y. The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata. Exp Dermatol. 2014;23:787–91. Minokawa Y, Sawada Y, Nakamura M. Lifestyle factors involved in the pathogenesis of alopecia areata. Int J Mol Sci. 2022;23:1038. Forstbauer LM, Brockschmidt FF, Moskvina V, et al. Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata. Eur J Hum Genet. 2012;20:326–32. Petukhova L, Duvic M, Hordinsky M, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 2010;466:113–7. Pham CT, Romero K, Almohanna HM, Griggs J, Ahmed A, Tosti A. The role of diet as an adjuvant treatment in scarring and nonscarring alopecia. Skin Appendage Disord. 2020;6:88–96. Kapoor B, Kapoor D, Gautam S, Singh R, Bhardwaj S. Dietary polyunsaturated fatty acids (PUFAs): uses and potential health benefits. Curr Nutr Rep. 2021;10:232–42. Lee J, Lee H, Kang S, Park W. Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances. Nutrients. 2016;8:23. Balić A, Vlašić D, Žužul K, Marinović B, Bukvić Mokos Z. Omega-3 versus omega-6 polyunsaturated fatty acids in the prevention and treatment of inflammatory skin diseases. Int J Mol Sci. 2020;21:741. Huang TH, Wang PW, Yang SC, Chou WL, Fang JY. Cosmetic and therapeutic applications of fish oil's fatty acids on the skin. Mar Drugs. 2018;16:256. Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids. 2018;132:41–8. Choque B, Catheline D, Rioux V, Legrand P. Linoleic acid: between doubts and certainties. Biochimie. 2014;96:14–21. Wei Y, Meng Y, Li N, Wang Q, Chen L. The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis. Food Funct. 2021;12:30–40. Hu X, Zhao J, Lin Z, et al. Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proc Natl Acad Sci U S A. 2021;119:e2106858119. Evans DM, Davey Smith G. Mendelian randomization: new applications in the coming age of hypothesis-free causality. Annu Rev Genomics Hum Genet. 2015;16:327–50. Gupta V, Walia GK, Sachdeva MP. Mendelian randomization: an approach for exploring causal relations in epidemiology. Public Health. 2017;145:113–9. Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37:658–65. Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46:1985–98. Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40:304–14. Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44:512–25. Simakou T, Butcher JP, Reid S, Henriquez FL. Alopecia areata: a multifactorial autoimmune condition. J Autoimmun. 2019;98:74–85. Ito T, Kageyama R, Nakazawa S, Honda T. Understanding the significance of cytokines and chemokines in the pathogenesis of alopecia areata. Exp Dermatol. 2020;29:726–32. McCusker MM, Grant-Kels JM. Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. Clin Dermatol. 2010;28:440–51. Melody SM, Vincent R, Mori TA, et al. Effects of omega-3 and omega-6 fatty acids on human placental cytokine production. Placenta. 2015;36:34–40. Johnson GH, Fritsche K. Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials. J Acad Nutr Diet. 2012;112:1029–41, 1041.e1. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003;108:155–60. Das UN. Essential fatty acids and their metabolites in the pathobiology of inflammation and its resolution. Biomolecules. 2021;11:1873. Chovarda E, Sotiriou E, Lazaridou E, Vakirlis E, Ioannides D. The role of prostaglandins in androgenetic alopecia. Int J Dermatol. 2021;60:730–5. Nichols AJ, Hughes OB, Canazza A, Zaiac MN. An open-label evaluator blinded study of the efficacy and safety of a new nutritional supplement in androgenetic alopecia: a pilot study. J Clin Aesthet Dermatol. 2017;10:52–6. Le Floc’h C, Cheniti A, Connétable S, Piccardi N, Vincenzi C, Tosti A. Effect of a nutritional supplement on hair loss in women. J Cosmet Dermatol. 2015;14:76–82. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002;21:495–505. Bennett M, Gilroy DW. Lipid mediators in inflammation. Microbiol Spectr. 2016;4:MCHD-0035. Töröcsik D, Weise C, Gericke J, et al. Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients. Exp Dermatol. 2019;28:177–89. |
| Contributed Indexing: | Keywords: Mendelian randomization; alopecia areata; docosahexaenoic acid; linoleic acid; omega-6; polyunsaturated fatty acids |
| Substance Nomenclature: | 25167-62-8 (Docosahexaenoic Acids) 0 (Fatty Acids, Omega-3) 0 (Fatty Acids, Omega-6) 0 (Fatty Acids, Unsaturated) 9KJL21T0QJ (Linoleic Acid) |
| Entry Date(s): | Date Created: 20260530 Date Completed: 20260717 Latest Revision: 20260828 |
| Update Code: | 20260828 |
| PubMed Central ID: | PMC13225558 |
| DOI: | 10.1097/MD.0000000000049058 |
| PMID: | 42216399 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1536-5964 |
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| DOI: | 10.1097/MD.0000000000049058 |