Academic Journal
Structural characteristics, modification, immunomodulation and anti-inflammatory of Polygonatum polysaccharides from three species: A comparative study.
| Τίτλος: | Structural characteristics, modification, immunomodulation and anti-inflammatory of Polygonatum polysaccharides from three species: A comparative study. |
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| Συγγραφείς: | Lee ZW; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Zhu Y; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Li X; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Wu C; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Li T; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Zhou D; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China., Yang X; Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China., Fan G; State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China; Co-Innovation Center for the Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China. Electronic address: fangongjian@njfu.edu.cn. |
| Πηγή: | Food research international (Ottawa, Ont.) [Food Res Int] 2026 Aug 31; Vol. 238, pp. 119465. Date of Electronic Publication: 2026 May 17. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Ottawa, Ontario, Canada : Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science, c1992- |
| Ιατρικοί όροι (MeSH): | Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Polygonatum*/chemistry , Polygonatum*/classification , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Immunomodulation*, Animals ; Humans ; Molecular Weight ; Structure-Activity Relationship |
| Περίληψη: | Polygonatum polysaccharides (PPs), derived from Polygonatum sibiricum, P. kingianum, and P. cyrtonema, have gained attention due to their important biological activities. However, differences in their structural characteristics lead to variations in physicochemical properties and functions. This review summarizes the main structural characteristics of PPs from the three species, including molecular weight, monosaccharide composition, and glycosidic linkages, and discusses their relationships with biological activities. Modification strategies, including physical, chemical, and biological approaches, are also discussed to illustrate how structure and function can be regulated. Overall, the biological activities of PPs are determined by the combined effects of multiple structural parameters, especially in immunomodulation and anti-inflammatory functions. However, challenges remain, including the lack of standardized analytical methods and limited understanding of precise structure-activity relationships. This review helps clarify the structure-activity relationships of PPs and points out key gaps for future research and application in functional foods. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anti-inflammatory; Immunomodulation; Polygonatum polysaccharides; Structural characteristics; Structural modification; Structure-activity relationship |
| Substance Nomenclature: | 0 (Anti-Inflammatory Agents) 0 (Plant Extracts) 0 (Polysaccharides) |
| Entry Date(s): | Date Created: 20260529 Date Completed: 20260529 Latest Revision: 20260601 |
| Update Code: | 20260601 |
| DOI: | 10.1016/j.foodres.2026.119465 |
| PMID: | 42215130 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-7145 |
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| DOI: | 10.1016/j.foodres.2026.119465 |