Academic Journal
Electrical characterization of single tumor cells with high accuracy using a low-cost microfluidic impedance cytometry.
| Τίτλος: | Electrical characterization of single tumor cells with high accuracy using a low-cost microfluidic impedance cytometry. |
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| Συγγραφείς: | Wang H; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Ren XD; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Kong WL; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Sun XG; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Wang CY; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Su N; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Li JM; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Li RX; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Li HZ; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Wu TH; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China., Huang Q; Department of Laboratory Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China; Department of Biomedical Materials Science, Army Medical University, Chongqing, 400038, China. Electronic address: qinghuang@tmmu.edu.cn. |
| Πηγή: | Biosensors & bioelectronics [Biosens Bioelectron] 2026 Oct 15; Vol. 310, pp. 118858. Date of Electronic Publication: 2026 May 26. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Advanced Technology Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989- |
| Ιατρικοί όροι (MeSH): | Biosensing Techniques*/instrumentation , Biosensing Techniques*/economics , Single-Cell Analysis*/instrumentation , Single-Cell Analysis*/economics , Microfluidic Analytical Techniques*/instrumentation , Neoplasms*/pathology , Neoplasms*/diagnosis, Tin Compounds/chemistry ; Polystyrenes/chemistry ; Flow Cytometry/instrumentation ; Electric Impedance ; Humans ; Equipment Design ; Lab-On-A-Chip Devices ; Cell Line, Tumor |
| Περίληψη: | In this paper, we proposed a low-cost and easily fabricated microfluidic impedance cytometer (HF-MIC) based on 3D hydrodynamic focusing for the electrical characterization and identification of tumor cells with high-accuracy. The detection electrodes and detection channel of HF-MIC were easily fabricated by laser cutting conductive film of indium tin oxide (ITO) glass and double-sided adhesive tapes, respectively. The fabrication and assembly period of the HF-MIC is shortened to less than 1 h and the cost is less than $4 per device. First, numerical methods explored the positional dependence of impedance signals and particle focusing behaviors. Then, the performance tests of the HF-MIC using polystyrene particles verified its ability to acquire impedance signals with high focusing efficiency (>94%), high focusing stability (CV < 0.08) and high SNR (>8 dB). Finally, key dielectric parameters-cell diameter (D (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest All the authors declare that they have no competing interests. |
| Contributed Indexing: | Keywords: 3D hydrodynamic focusing; Cell dielectric properties; Identifying cell types; Label-free identification; Microfluidic impedance cytometer |
| Substance Nomenclature: | 71243-84-0 (indium tin oxide) 0 (Tin Compounds) 0 (Polystyrenes) |
| Entry Date(s): | Date Created: 20260529 Date Completed: 20260611 Latest Revision: 20260611 |
| Update Code: | 20260611 |
| DOI: | 10.1016/j.bios.2026.118858 |
| PMID: | 42214849 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4235 |
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| DOI: | 10.1016/j.bios.2026.118858 |