Academic Journal
Sage (Salvia spp.) as a multi-target resource for healthy aging: Current evidence and perspectives.
| Τίτλος: | Sage (Salvia spp.) as a multi-target resource for healthy aging: Current evidence and perspectives. |
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| Συγγραφείς: | Giacomini I; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Sarill M; Institute of Oncology Research, Bellinzona, Switzerland., Cocetta V; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Montopoli M; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy. Electronic address: monica.montopoli@unipd.it. |
| Πηγή: | Mechanisms of ageing and development [Mech Ageing Dev] 2026 Aug; Vol. 232, pp. 112204. Date of Electronic Publication: 2026 May 28. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Science Ireland Original Publication: Lausanne, Elsevier Sequoia. |
| Ιατρικοί όροι (MeSH): | Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Healthy Aging*/drug effects , Salvia*/chemistry , Antioxidants*/pharmacology , Salvia officinalis*/chemistry , Aging*, Oxidative Stress/drug effects ; Cellular Senescence/drug effects ; Skin Aging/drug effects ; Humans ; Animals |
| Περίληψη: | Aging is driven by interacting processes, including oxidative stress, chronic low-grade inflammation, cellular senescence, and dysregulated tissue remodeling. Salvia (sage) is the largest genus in the Lamiaceae and is widely used in traditional medicine, foods, and topical preparations, with pronounced chemodiversity across essential oils and polar extracts. This review summarizes and critically evaluates the anti-aging potential of eight selected Salvia species (S. officinalis, S. yangii, S. sahendica, S. miltiorrhiza, S. hispanica, S. haenkei, S. verticillata, and S. haematodes) by examining their effects on key aging-related mechanisms. Across species, Salvia preparations repeatedly show antioxidant and anti-inflammatory activity in chemical and cellular systems, with select studies demonstrating protection in UVB/photoaging models. Antimicrobial and anti-biofilm effects are reported for specific extracts and essential oils. Senescence-linked activity is most consistently supported for S. haenkei, including in vivo evidence with a standardized preparation. Fibrosis- and sarcopenia-relevant outcomes are emerging, mainly from disease-driven remodeling or metabolic models. Human evidence remains limited but includes topical studies assessing UV erythema and wrinkle-related parameters. Salvia species provide multi-target bioactivities relevant to aging biology; however, variability in extract composition, incomplete standardization, and scarce controlled human data limit cross-study comparability. Future work should prioritize standardized preparations and robust clinical designs. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest Monica Montopoli is inventor in patents no. WO2019121425A1 and WO2019121427A1. |
| Contributed Indexing: | Keywords: Aging; Inflammaging; Photoaging; Salvia; Senescence |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Antioxidants) |
| Entry Date(s): | Date Created: 20260529 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260709 |
| DOI: | 10.1016/j.mad.2026.112204 |
| PMID: | 42214507 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-6216 |
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| DOI: | 10.1016/j.mad.2026.112204 |