Academic Journal
Improved reproductive outcomes and metabolomic profiles in swine induced by red light-treated semen†.
| Τίτλος: | Improved reproductive outcomes and metabolomic profiles in swine induced by red light-treated semen†. |
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| Συγγραφείς: | Sun Y; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China.; College of Animal Science, Guangxi Agricultural Engineering Vocational and Technical College, Nanning, PR China., Yang X; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China.; Shenzhen Quansheng Biological Technology Co., Ltd, Shenzhen, PR China., Feng Y; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China., Qin J; Guangxi Yangxiang Co., Ltd., Guigang, PR China., He J; School of Life Science and Engineering, Foshan University, Foshan, PR China., Li Z; School of Life Science and Engineering, Foshan University, Foshan, PR China., Pang Y; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China., Mi BTT; Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Ho Chi Minh City, Vietnam., Zhu Q; School of Life Science and Engineering, Foshan University, Foshan, PR China., Zhu X; School of Life Science and Engineering, Foshan University, Foshan, PR China., Chen F; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China.; Guangxi Yangxiang Co., Ltd., Guigang, PR China., Zhao Y; China (Guangxi)-Vietnam Joint Laboratory on Intelligent Pig Farming, College of Animal Science and Technology, Guangxi-University, Nanning, PR China.; Guangxi Yangxiang Co., Ltd., Guigang, PR China. |
| Πηγή: | Biology of reproduction [Biol Reprod] 2026 Aug 18; Vol. 115 (2), pp. 619-633. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0207224 Publication Model: Print Cited Medium: Internet ISSN: 1529-7268 (Electronic) Linking ISSN: 00063363 NLM ISO Abbreviation: Biol Reprod Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : New York : Oxford University Press Original Publication: Champaign, Ill. : Society for the Study of Reproduction |
| Ιατρικοί όροι (MeSH): | Semen*/radiation effects , Semen*/metabolism , Metabolome*/radiation effects , Reproduction*/radiation effects , Reproduction*/physiology , Red Light*, Swine/physiology ; Insemination, Artificial/veterinary ; Semen Analysis/veterinary ; Sperm Motility/radiation effects ; Spermatozoa/radiation effects ; Animals ; Male ; Female ; Pregnancy ; Metabolomics |
| Περίληψη: | This study investigated the effects of red light-emitting diodes (LED) light exposure on boar semen quality, sperm metabolism, and reproductive performance in sows. A total of 60 semen samples were collected from Duroc boars and randomly assigned to 6 light treatment procedures and a control. Among these, Procedure #1 (red light for 13 min-dark for 10 min-red light for 13 min) significantly improved sperm motility indicators, particularly reducing the amplitude of lateral head displacement and enhancing beat-cross frequency over time (P < 0.05). Flow cytometry analysis revealed that this procedure preserved mitochondrial membrane potential and acrosome integrity. A large-scale field trial involving 1499 sows across four breeds demonstrated that insemination using red light-treated semen (Procedure #1) significantly increased pregnancy and delivery rates in Large White and Yorkshire sows, along with higher litter birth weight, total number born, and number born alive (P < 0.05). Untargeted liquid chromatography-tandem mass spectrometry metabolomics identified 60 differential metabolites and revealed distinct clustering between treated and control groups. Enrichment and receiver operating characteristic analyses highlighted key altered pathways, including retinol metabolism, fatty acid degradation, sphingolipid metabolism, and arachidonic acid metabolism. Metabolites such as vitamin A, palmitoylcarnitine, psychosine, and prostaglandin E2 showed potential as biomarkers of red-light exposure. These findings suggest that optimized red LED exposure enhances boar semen quality and sow reproductive outcomes by modulating sperm motility and metabolic profiles, offering a novel strategy to improve reproductive efficiency in swine production. (© The Author(s) 2026. Published by Oxford University Press on behalf of the Society for the Study of Reproduction. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Contributed Indexing: | Keywords: artificial insemination; boar sperm motility; red light-emitting diode irradiation; reproductive performance; untargeted metabolomics |
| Entry Date(s): | Date Created: 20260529 Date Completed: 20260818 Latest Revision: 20261004 |
| Update Code: | 20261005 |
| DOI: | 10.1093/biolre/ioag114 |
| PMID: | 42213057 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1529-7268 |
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| DOI: | 10.1093/biolre/ioag114 |