Academic Journal
Hemodynamic impact of blood viscosity in intracranial atherosclerotic arteries with varying stenosis severity: A non-newtonian computational fluid dynamics patient specific study.
| Τίτλος: | Hemodynamic impact of blood viscosity in intracranial atherosclerotic arteries with varying stenosis severity: A non-newtonian computational fluid dynamics patient specific study. |
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| Συγγραφείς: | Zhengyao L; Department of Aerospace Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia., Muhamad Nazri MNI; Department of Aerospace Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia., Basri AA; Department of Aerospace Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia., Tamagawa M; Department of Biological Functions Engineering, Kyushu Institute of Technology, Fukuoka, Japan., Sagara K; Department of Biological Functions Engineering, Kyushu Institute of Technology, Fukuoka, Japan., Khan AHKY; Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia., Mohd Tohit ER; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. |
| Πηγή: | PloS one [PLoS One] 2026 May 28; Vol. 21 (5), pp. e0342713. Date of Electronic Publication: 2026 May 28 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| Ιατρικοί όροι (MeSH): | Intracranial Arteriosclerosis*/physiopathology , Blood Viscosity* , Hemodynamics*, Constriction, Pathologic/physiopathology ; Middle Cerebral Artery/physiopathology ; Humans ; Hydrodynamics ; Models, Cardiovascular ; Computer Simulation ; Stress, Mechanical ; Blood Flow Velocity |
| Περίληψη: | Intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke, yet geometric stenosis alone may not fully reflect the functional hemodynamic burden of a lesion. This study used computational fluid dynamics (CFD) with a shear-thinning non-Newtonian Carreau viscosity model to quantify the combined effects of stenosis severity and blood viscosity on intracranial hemodynamics. A middle cerebral artery (MCA) stenosis model with an original ~70% narrowing was reconstructed from computed tomography angiography, and additional idealized stenosis variants (30%, 50%, and 90%) were generated on the same anatomical background to enable controlled comparisons. Three viscosity states (below-normal, normal, and high) were simulated under transient, incompressible, laminar flow with rigid walls and identical boundary conditions. Velocity, pressure, and wall shear stress (WSS), oscillatory shear index (OSI) and time-averaged wall shear stress (TAWSS) were evaluated. The results show that flow behavior is governed by the combined influence of geometry and rheology, rather than by stenosis severity alone. Severe stenosis produced a dual pathological shear environment, characterized by elevated WSS within the stenotic region and disturbed low-shear flow downstream. In addition, TAWSS showed a non-monotonic response, increasing up to 70% stenosis and then decreasing at 90% stenosis. OSI also showed viscosity-dependent elevation under severe stenosis, with values ranging from approximately 0.38 to 0.48, indicating enhanced oscillatory and disturbed flow.These findings support integrating non-Newtonian hemorheology and hemodynamic metrics with geometric assessment to improve ICAS risk stratification and inform hemodynamics-guided intervention timing. (Copyright: © 2026 Zhengyao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
| References: | J Biomech. 2006;39(5):818-32. (PMID: 16488221) Cardiovasc Diagn Ther. 2015 Feb;5(1):63-6. (PMID: 25774350) Front Neurol. 2018 Sep 20;9:786. (PMID: 30294297) J Stroke Cerebrovasc Dis. 2021 Oct;30(10):106009. (PMID: 34343837) Int J Adv Eng Sci Appl Math. 2016 Mar;8(1):40-60. (PMID: 27546999) Diabetes Care. 2014 Feb;37(2):488-92. (PMID: 24062332) Biomed Res Int. 2015;2015:682054. (PMID: 25710019) PeerJ. 2025 Apr 28;13:e19336. (PMID: 40313393) Heliyon. 2023 Feb 10;9(2):e13527. (PMID: 36852079) PLoS One. 2026 Mar 11;21(3):e0334297. (PMID: 41812097) Biomech Model Mechanobiol. 2022 Aug;21(4):1217-1232. (PMID: 35614372) Biomech Model Mechanobiol. 2020 Oct;19(5):1477-1490. (PMID: 31894438) Med Biol Eng Comput. 2025 Jul;63(7):2173-2190. (PMID: 39961912) Med Eng Phys. 2000 May;22(4):265-77. (PMID: 11018458) Sci Rep. 2025 Mar 20;15(1):9604. (PMID: 40113854) Theor Biol Med Model. 2009 May 15;6:7. (PMID: 19445663) Basic Res Cardiol. 1989 Mar-Apr;84(2):111-24. (PMID: 2658951) Front Physiol. 2021 Sep 06;12:718540. (PMID: 34552505) J R Soc Interface. 2010 Jun 6;7(47):967-88. (PMID: 20022896) Sci Rep. 2025 Feb 10;15(1):4896. (PMID: 39929978) Eur Heart J. 2019 Nov 1;40(41):3421-3433. (PMID: 31566246) Sci Rep. 2018 Apr 3;8(1):5493. (PMID: 29615730) Front Bioeng Biotechnol. 2024 Aug 22;12:1467257. (PMID: 39239254) Interv Neurol. 2015 Oct;4(1-2):48-50. (PMID: 26600797) Oper Neurosurg. 2020 Jun 1;18(6):599-605. (PMID: 31848612) J Biomech. 2006;39(6):1116-28. (PMID: 16549100) Pharmaceutics. 2025 Aug 07;17(8):. (PMID: 40871049) Prog Cardiovasc Dis. 2007 Mar-Apr;49(5):307-29. (PMID: 17329179) Front Cardiovasc Med. 2025 Nov 18;12:1705263. (PMID: 41341290) CNS Neurosci Ther. 2026 Jan;32(1):e70690. (PMID: 41524620) PLoS One. 2014 May 12;9(5):e97531. (PMID: 24818753) Heliyon. 2024 Feb 18;10(4):e26622. (PMID: 38420368) Brain Behav. 2012 Jan;2(1):42-52. (PMID: 22574273) ASAIO J. 2021 Jun 1;67(6):666-674. (PMID: 33164999) Bioengineering (Basel). 2025 Sep 28;12(10):. (PMID: 41155041) Ann Biomed Eng. 2013 Jul;41(7):1411-27. (PMID: 23229281) Sci Rep. 2025 Dec 4;16(1):921. (PMID: 41345449) |
| Entry Date(s): | Date Created: 20260528 Date Completed: 20260717 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13218500 |
| DOI: | 10.1371/journal.pone.0342713 |
| PMID: | 42207804 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0342713 |