Academic Journal
Amygdala microstructural changes in subjective cognitive decline: A diffusion kurtosis and neurite orientation dispersion and density imaging study.
| Τίτλος: | Amygdala microstructural changes in subjective cognitive decline: A diffusion kurtosis and neurite orientation dispersion and density imaging study. |
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| Συγγραφείς: | Flaherty R; Department of Radiology, New York University Grossman School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA., Sui YV; Department of Radiology, New York University Grossman School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, USA., Masurkar AV; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.; Department of Neurology, New York University Grossman School of Medicine, Center for Cognitive Neurology, New York, NY, USA.; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA., Youss ZB; Department of Radiology, New York University Grossman School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA., Wisniewski T; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.; Department of Neurology, New York University Grossman School of Medicine, Center for Cognitive Neurology, New York, NY, USA.; Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, USA.; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA., Rusinek H; Department of Radiology, New York University Grossman School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, USA.; Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA., Lazar M; Department of Radiology, New York University Grossman School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, New York, NY, USA.; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA. |
| Πηγή: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2026 Jul; Vol. 112 (2), pp. 728-740. Date of Electronic Publication: 2026 May 27. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2024- : [Thousand Oaks, CA] : SAGE Publications Original Publication: Amsterdam ; Washington : IOS Press, c1998- |
| Ιατρικοί όροι (MeSH): | Amygdala*/diagnostic imaging , Amygdala*/pathology , Cognitive Dysfunction*/diagnostic imaging , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/psychology , Neurites*/pathology, Diffusion Magnetic Resonance Imaging/methods ; Diffusion Tensor Imaging/methods ; Humans ; Male ; Female ; Aged ; Middle Aged ; Anisotropy |
| Περίληψη: | BackgroundPeople with subjective cognitive decline (SCD) are at increased risk of Alzheimer's disease. Prior research has suggested that amygdala volume may be more sensitive than hippocampal volume in detecting differences between SCD and age-matched controls, as well as in predicting SCD conversion to mild cognitive impairment. However, the microstructure underlying this volumetric change remains unclear.ObjectiveThis study evaluated amygdala microstructural differences in SCD versus control participants as well as associations between amygdala microstructure and volume, age, memory performance, anxiety, and depression using diffusion imaging.MethodsDiffusion tensor imaging, diffusion kurtosis imaging, and neurite orientation dispersion and density imaging were fit to diffusion MRI images. Group differences and correlations between diffusion metrics, age, memory, anxiety, and depression were assessed in 123 SCD versus 194 age-matched controls over age 55.ResultsIn the left amygdala, SCD participants had significantly lower fractional anisotropy (FA), lower kurtosis fractional anisotropy (KFA), and higher free water fraction (FWF). KFA was lower in the right amygdala in SCD. There were no significant group differences in the amygdala volume. Bilateral KFA negatively correlated with FWF, a marker of neuroinflammation and neurodegeneration. Left FA negatively correlated with orientation dispersion index, a marker of neuritic branching. Right KFA correlated with age only in SCD, while left FA correlated with anxiety only in controls.ConclusionsKFA is sensitive to group differences between SCD and controls in bilateral amygdala. KFA may reflect neuroinflammation and increased sensitivity to aging in the amygdala in SCD. |
| Competing Interests: | Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Grant Information: | P30 AG008051 United States AG NIA NIH HHS |
| Contributed Indexing: | Keywords: Alzheimer's disease; aging; amygdala; anxiety; cognitive dysfunction; diagnostic self evaluation; diffusion magnetic resonance imaging; diffusion tensor imaging; inflammation; pathology |
| Entry Date(s): | Date Created: 20260527 Date Completed: 20260707 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| DOI: | 10.1177/13872877261452604 |
| PMID: | 42198982 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1875-8908 |
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| DOI: | 10.1177/13872877261452604 |