Academic Journal
Computational auditory periphery models: The return of the rodent.
| Τίτλος: | Computational auditory periphery models: The return of the rodent. |
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| Συγγραφείς: | Thienpont M; Hearing Technology @ WAVES Team, Department of Information Technology, Ghent University, Ghent, Belgium. Electronic address: morgan.thienpont@ugent.be., Deloche F; Hearing Technology @ WAVES Team, Department of Information Technology, Ghent University, Ghent, Belgium., Keshishzadeh S; Hearing Technology @ WAVES Team, Department of Information Technology, Ghent University, Ghent, Belgium., Kiselev D; Institute for Neurosciences Montpellier, University of Montpellier, Montpellier, France., Bourien J; Institute for Neurosciences Montpellier, University of Montpellier, Montpellier, France., Puel JL; Institute for Neurosciences Montpellier, University of Montpellier, Montpellier, France., Buran BN; Oregon Hearing Research Center (OHRC), Department of Otolaryngology - Head & Neck Surgery, Oregon Health & Science University, Portland, OR, USA; VA National Center for Rehabilitative Auditory Research (NCRAR), Veterans Affairs Portland Health Care System, Portland, OR, USA., Bramhall N; VA National Center for Rehabilitative Auditory Research (NCRAR), Veterans Affairs Portland Health Care System, Portland, OR, USA; Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, Portland, OR, USA., Verhulst S; Hearing Technology @ WAVES Team, Department of Information Technology, Ghent University, Ghent, Belgium. |
| Πηγή: | Hearing research [Hear Res] 2026 Aug; Vol. 478, pp. 109663. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7900445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5891 (Electronic) Linking ISSN: 03785955 NLM ISO Abbreviation: Hear Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Cochlea*/physiology , Hearing Loss, Sensorineural*/physiopathology , Computer Simulation* , Hearing*, Cochlear Nerve/physiopathology ; Cochlear Nerve/physiology ; Basilar Membrane/physiology ; Auditory Pathways/physiology ; Auditory Pathways/physiopathology ; Animals ; Gerbillinae ; Species Specificity ; Mice ; Humans ; Acoustic Stimulation ; Otoacoustic Emissions, Spontaneous ; Nonlinear Dynamics |
| Περίληψη: | Animal experiments have provided many insights on auditory function, notably in cases of sensorineural hearing loss (SNHL). However, it is not always clear how these findings translate to the human auditory system, especially in clinically relevant contexts. Cross-species computational models of the auditory periphery can help bridge the gap between non-invasive human diagnostics and experimental evidence from animal studies. In this work we adapted a one-dimensional (1-D) nonlinear cochlear transmission-line (TL) model designed for the human auditory periphery to mouse and gerbil, enabling a single computational framework for cross-species research on SNHL. Species-specific anatomical and physiological parameters - including basilar membrane (BM) length and width, stapes area, middle-ear transfer functions, and characteristic-frequency range - were adjusted to match each species' auditory periphery and hearing range. Other cochlear parameters were calibrated to reproduce realistic cochlear tuning and compressive growth. The adapted mouse and gerbil models were validated against experimental species-specific BM velocity level-growth characteristics, auditory-nerve (AN) tuning curves, and distortion-product otoacoustic emissions (DPOAEs). Simulated AN outputs reasonably matched empirical measurements, including realistic AN thresholds and frequency selectivity. However, the discrepancy between simulations and measurements became larger for cochlear sections closer to the base or apex. Simulations of auditory-nerve synaptopathy reproduced observed differences in recorded auditory brainstem and envelope following responses from mice and gerbils with cochlear synaptopathy. However, OHC individualization of the mouse model based on DPOAEs failed to faithfully reproduce individual measured data, although inter-group differences in OHC damage were captured. Our findings demonstrate that biophysically grounded auditory periphery models can be translated across species while preserving realistic sound-coding properties and pathophysiological alterations. This approach refines the interpretation of animal data in specific hypotheses of human hearing, facilitates the development of new stimuli to test in rodents, and may enable in silico investigations of OHC loss, synaptopathy, and their functional consequences. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Σχόλια: | Update of: ArXiv. 2026 May 20:arXiv:2605.19070v2.. (PMID: 42238072) |
| Grant Information: | R01 DC020423 United States DC NIDCD NIH HHS |
| Contributed Indexing: | Keywords: Computational model; Gerbil; Mouse |
| Entry Date(s): | Date Created: 20260526 Date Completed: 20260701 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13343138 |
| DOI: | 10.1016/j.heares.2026.109663 |
| PMID: | 42190305 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-5891 |
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| DOI: | 10.1016/j.heares.2026.109663 |