Academic Journal
Impact of in-stent neointima and its association with in-stent restenosis after carotid artery stenting.
| Τίτλος: | Impact of in-stent neointima and its association with in-stent restenosis after carotid artery stenting. |
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| Συγγραφείς: | Kuwabara M; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan. Electronic address: m214028@gmail.com., Ishii D; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan., Hara T; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan., Matsuda S; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan., Kume S; Department of Clinical Laboratory, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan., Yoshioka M; Department of Clinical Laboratory, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan., Horie N; Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi, Hiroshima 734-8551, Japan. |
| Πηγή: | European journal of radiology [Eur J Radiol] 2026 Sep; Vol. 202, pp. 112944. Date of Electronic Publication: 2026 May 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Science Ireland Ltd Original Publication: Stuttgart ; New York : Thieme, [c1981- |
| Ιατρικοί όροι (MeSH): | Stents*/statistics & numerical data , Stents*/adverse effects , Carotid Stenosis*/diagnostic imaging , Carotid Stenosis*/surgery , Carotid Stenosis*/epidemiology , Graft Occlusion, Vascular*/diagnostic imaging , Graft Occlusion, Vascular*/epidemiology , Neointima*/diagnostic imaging , Ultrasonography, Carotid Arteries*, Humans ; Female ; Male ; Aged ; Risk Factors ; Treatment Outcome ; Recurrence ; Middle Aged ; Ultrasonography ; Sensitivity and Specificity |
| Περίληψη: | Objective: Details of in-stent neointima (ISN) that form within a stent after carotid artery stenting (CAS) remain unknown. We aimed to investigate the characteristics of ISN observed on follow-up ultrasonography (US) after CAS and examine its association with in-stent restenosis (ISR). Materials & Methods: A total of 371 consecutive patients diagnosed with carotid artery stenosis who underwent CAS and were followed up for at least 18 months between 2008 and 2023 were included. US was conducted at 1, 3, 6, and 12 months after CAS and every 6 months thereafter. Factors associated with ISN formation and its timing were investigated. Additionally, the location of ISN development within the stent and its relationship with ISR were examined. Results: ISN was confirmed in 221 patients. Significant factors associated with ISN formation included use of closed-cell stents and higher postoperative stenosis rate. The median time for ISN detection was 3 months (mean 3.27 ± 2.09 months). The most common locations of ISN formation were the side with the highest plaque volume on the short axis and the stent's proximal edge on the long axis. There were 17 patients with ISR, and ISN thickness was an independent risk factor for ISR development (p = 0.047). The cutoff value of ISN thickness for detecting ISR was 0.80 mm. Conclusions: ISN development is associated with procedural technique and exhibits both temporal and segment-specific characteristics. Additionally, patients with an ISN thickness ≥ 0.80 mm on carotid US after CAS require careful follow-up, considering their greater ISR risk. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Carotid artery stenosis; Carotid artery stenting; In-stent restenosis; In-stentneointima; Ultrasonography |
| Entry Date(s): | Date Created: 20260522 Date Completed: 20260613 Latest Revision: 20260613 |
| Update Code: | 20260613 |
| DOI: | 10.1016/j.ejrad.2026.112944 |
| PMID: | 42172739 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-7727 |
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| DOI: | 10.1016/j.ejrad.2026.112944 |