Academic Journal
Real-world venetoclax dosing patterns and treatment persistence in patients with acute myeloid leukemia: a community pharmacy database study in Japan.
| Τίτλος: | Real-world venetoclax dosing patterns and treatment persistence in patients with acute myeloid leukemia: a community pharmacy database study in Japan. |
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| Συγγραφείς: | Goshima Y; Department of Hematology, Nippon Medical School, Tokyo, Japan.; Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) Program, RIKEN, Wako, Saitama, Japan., Saika T; Patient Engagement Frontier Medical Science, KAKEHASHI Inc, Tokyo, Japan.; Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan., Kado Y; Patient Engagement Frontier Medical Science, KAKEHASHI Inc, Tokyo, Japan., Yamazaki M; Department of Hematology, Nippon Medical School, Tokyo, Japan.; Patient Engagement Frontier Medical Science, KAKEHASHI Inc, Tokyo, Japan., Takebe T; Patient Engagement Frontier Medical Science, KAKEHASHI Inc, Tokyo, Japan., Yui S; Department of Hematology, Nippon Medical School, Tokyo, Japan. |
| Πηγή: | Leukemia & lymphoma [Leuk Lymphoma] 2026 Jul; Vol. 67 (8), pp. 1788-1795. Date of Electronic Publication: 2026 May 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE |
| Imprint Name(s): | Publication: [Philadelphia, PA] : Taylor & Francis Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989- |
| Ιατρικοί όροι (MeSH): | Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/epidemiology , Bridged Bicyclo Compounds, Heterocyclic*/administration & dosage , Bridged Bicyclo Compounds, Heterocyclic*/therapeutic use , Sulfonamides*/administration & dosage , Sulfonamides*/therapeutic use , Antineoplastic Agents*/administration & dosage , Antineoplastic Agents*/therapeutic use, Japan/epidemiology ; Pharmacies/statistics & numerical data ; Humans ; Retrospective Studies ; Female ; Aged ; Male ; Aged, 80 and over ; Databases, Factual ; Middle Aged |
| Περίληψη: | Venetoclax (VEN)-based regimens are widely used for patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy, but VEN dosing patterns and their relation to treatment persistence are not well described. We conducted a retrospective longitudinal study using de-identified dispensing records from Japanese community pharmacies to characterize VEN dosing patterns and treatment persistence in routine practice. Patients (n = 162) were clustered by mean daily VEN dose and dosing frequency, yielding four groups defined by high versus low dose and high versus low frequency. Treatment persistence was longer in the low-frequency clusters, where there was a clearer association with dosing frequency than with mean daily dose. Strong CYP3A4 inhibitor use was more common in low-dose clusters, consistent with dose adjustment when strong inhibitors are coadministered. These findings highlight heterogeneous real-world VEN use and its implications for treatment persistence. |
| Contributed Indexing: | Keywords: Acute myeloid leukemia; dosing patterns; real-world data; treatment persistence; venetoclax |
| Substance Nomenclature: | 0 (Bridged Bicyclo Compounds, Heterocyclic) N54AIC43PW (venetoclax) 0 (Sulfonamides) 0 (Antineoplastic Agents) |
| Entry Date(s): | Date Created: 20260522 Date Completed: 20260701 Latest Revision: 20260701 |
| Update Code: | 20260702 |
| DOI: | 10.1080/10428194.2026.2665793 |
| PMID: | 42171330 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1029-2403 |
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| DOI: | 10.1080/10428194.2026.2665793 |