Academic Journal
Memory Cell and Antibody Responses Following a Single Versus Two Doses of Escherichia coli-Produced Vaccine Against Human Papillomavirus Types 16 and 18: A Real-World Study in Chinese Girls.
| Τίτλος: | Memory Cell and Antibody Responses Following a Single Versus Two Doses of Escherichia coli-Produced Vaccine Against Human Papillomavirus Types 16 and 18: A Real-World Study in Chinese Girls. |
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| Συγγραφείς: | Wen T; Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Dong L; Institute of Biomedical Sciences, Shanxi University, Taiyuan, China., Li J; National Institutes for Food and Drug Control (NIFDC), Beijing, China., Feng Y; Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Nie L; National Institutes for Food and Drug Control (NIFDC), Beijing, China., Li Z; Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhang L; National Institutes for Food and Drug Control (NIFDC), Beijing, China., Hu S; Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Huang W; National Institutes for Food and Drug Control (NIFDC), Beijing, China., Zhao F; Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Basu P; Early Detection, Prevention & Infections Branch, International Agency for Research on Cancer, Lyon, France. |
| Πηγή: | International journal of cancer [Int J Cancer] 2026 Oct 15; Vol. 159 (8), pp. 1904-1916. Date of Electronic Publication: 2026 May 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| Ιατρικοί όροι (MeSH): | Antibodies, Viral*/immunology , Antibodies, Viral*/blood , Human papillomavirus 16*/immunology , Human papillomavirus 18*/immunology , Immunologic Memory*/immunology , Papillomavirus Infections*/prevention & control , Papillomavirus Infections*/immunology , Papillomavirus Infections*/virology , Papillomavirus Vaccines*/immunology , Papillomavirus Vaccines*/administration & dosage, Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/blood ; Antibody Formation/immunology ; B-Lymphocytes/immunology ; Escherichia coli/genetics ; Immunoglobulin G/immunology ; Immunoglobulin G/blood ; T-Lymphocytes/immunology ; Adolescent ; Child ; Female ; Humans ; China |
| Περίληψη: | A comprehensive profile of immunogenicity induced by a single dose of human papillomavirus (HPV) vaccination has yet to be presented. We report interim data from an ongoing non-interventional real-world study comparing the memory cell and antibody responses following single- and two-dose regimens of the Escherichia coli-produced HPV-16/18 vaccine in Chinese girls aged 9-14 years. HPV-16/18-specific neutralizing antibodies, IgG antibodies, and memory B- and T-cell responses were assessed and compared between the single-dose and two-dose groups. The results showed that among 492 per-protocol participants (298 two-dose; 194 single-dose), the median time from Dose 1 to blood sampling was 12.07 months. Single-dose neutralizing antibody seropositivity exceeded 90% for HPV-16 and approached 80% for HPV-18. The antibody avidity index of HPV-16 IgG after a single dose was non-inferior to that after two doses (lower bound of the geometric mean avidity ratio > 0.5). Both dosing schedules induced HPV-16/18-specific memory B- and T-cell responses with similar positivity and geometric means (p > 0.05). Therefore, a single dose of the E. coli-produced HPV-16/18 vaccine elicited robust antibody quantity and quality, with memory B- and T-cell responses comparable to those induced by two doses, supporting its potential for population-level implementation and contribution to the WHO target of vaccinating 90% of girls. (© 2026 UICC.) |
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| Grant Information: | 82273273 National Natural Science Foundation of China; KY202204006 Science and Technology Partnership Program, Ministry of Science and Technology of China; INV-031449 United States GATES Gates Foundation |
| Contributed Indexing: | Keywords: Escherichia coli‐produced human papillomavirus vaccines; antibody avidity; antibody titers; memory B cells; single dose |
| Substance Nomenclature: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (Immunoglobulin G) 0 (Papillomavirus Vaccines) |
| Entry Date(s): | Date Created: 20260521 Date Completed: 20260821 Latest Revision: 20260824 |
| Update Code: | 20260825 |
| PubMed Central ID: | PMC13495845 |
| DOI: | 10.1002/ijc.70553 |
| PMID: | 42163577 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1097-0215 |
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| DOI: | 10.1002/ijc.70553 |