Academic Journal
Demographics and clinical implications of a global bibliographic profile for the hypertrophic cardiomyopathy literature over 66 years (1960-2025).
| Title: | Demographics and clinical implications of a global bibliographic profile for the hypertrophic cardiomyopathy literature over 66 years (1960-2025). |
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| Authors: | Sayed A; Rochester General Hospital, Rochester, New York, United States of America., Rowin EJ; Hypertrophic Cardiomyopathy Center, Lahey Hospital and Medical Center, Burlington, MA, United States of America. Electronic address: Ethan.Rowin@lahey.org., Maron MS; Hypertrophic Cardiomyopathy Center, Lahey Hospital and Medical Center, Burlington, MA, United States of America., Maron BJ; Hypertrophic Cardiomyopathy Center, Lahey Hospital and Medical Center, Burlington, MA, United States of America. |
| Source: | International journal of cardiology [Int J Cardiol] 2026 Sep 15; Vol. 459, pp. 134571. Date of Electronic Publication: 2026 May 19. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| MeSH Terms: | Bibliometrics*/history , Cardiomyopathy, Hypertrophic*/epidemiology , Cardiomyopathy, Hypertrophic*/diagnosis , Demography*/trends , Periodicals as Topic*/trends , Global Health*, Humans |
| Abstract: | Background: Hypertrophic cardiomyopathy (HCM) is a common cardiac disease clinically-recognized worldwide; however, limited information is available concerning the demographic profile and significance of its evolving peer-reviewed literature. Objectives: Assess the global distribution and characteristics of the HCM-related literature from 1960 to 2024 . Methods: Publications describing HCM were retrieved from the National Library of Medicine via PubMed from 1960 to 2025. Changes in publication counts across the 66 years were quantified. Additionally, trends were stratified by country of origin and geographic region. Results: The number of HCM publications increased significantly over time (P < 0.001), from 59 in 1960-1965 to 6454 in 2020-2025, a 109-fold increase that notably exceeded the increase in overall cardiovascular publications during the same time-period. The number of countries from which papers originated also increased significantly (P < 0.001), from 11 in 1960-1965 to 78 in 2020-2025, a 7-fold increase. Overall, the largest contributor was the U.S. (n = 5513 publications comprising 30% of the literature), followed by China (n = 1819, 10%), Japan (n = 1729, 9%), Italy (n = 1302, 7%), and United Kingdom (n = 1194, 7%). Notably, publications from China increased by 203-fold from 1960 to 2000 to 2020-2025, with Asia becoming the predominant continent in 2025. Fifty-percent of publications from countries contributing only >2010 were not original investigations, and none appeared in high-impact journals. Conclusions: While the US has remained the largest contributor of HCM-related publications >65 years, the peer-reviewed literature has become increasingly diverse, now including almost 100 countries globally and an increasingly substantial proportion from China and the Asian continent. This evolving profile has allowed for enhanced understanding of HCM and its particularly broad clinical spectrum, likely improving care for patients with this disease worldwide. However, sparse data from several populous regions constitute an unmet need in HCM. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors have no disclosures relevant to the content of this manuscript. |
| Contributed Indexing: | Keywords: Hypertrophic cardiomyopathy; global dissemination |
| Entry Date(s): | Date Created: 20260520 Date Completed: 20260613 Latest Revision: 20260619 |
| Update Code: | 20260619 |
| DOI: | 10.1016/j.ijcard.2026.134571 |
| PMID: | 42162851 |
| Database: | MEDLINE |
| ISSN: | 1874-1754 |
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| DOI: | 10.1016/j.ijcard.2026.134571 |