Academic Journal
Repair of radiographic joint damage in psoriatic arthritis: a cohort study.
| Τίτλος: | Repair of radiographic joint damage in psoriatic arthritis: a cohort study. |
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| Συγγραφείς: | Haddad A; Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Rheumatology Unit, Carmel Medical Center, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Kharouf F; Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Rheumatology Unit, Department of Medicine, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Lee KA; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada., Zou L; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada., Pereira D; Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada., Cook RJ; Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada., Chandran V; Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Gladman DD; Gladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, Ontario, Canada.; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. |
| Πηγή: | Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2026 Jun 03; Vol. 65 (6). |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, UK : Avenel, N.J. : Oxford University Press ; Distributed by Mercury International, c1999- |
| Ιατρικοί όροι (MeSH): | Arthritis, Psoriatic*/diagnostic imaging , Arthritis, Psoriatic*/drug therapy , Antirheumatic Agents*/therapeutic use , Hand Joints*/diagnostic imaging , Foot Joints*/diagnostic imaging, Humans ; Male ; Female ; Adult ; Middle Aged ; Disease Progression ; Radiography ; Severity of Illness Index ; Cohort Studies ; Prognosis |
| Περίληψη: | Objectives: Robust evidence on the repair of radiographic damage in psoriatic arthritis (PsA) is limited. In this study, we determined the frequency of damage repair and identified its predictors. Methods: We performed biennial radiographic assessments of the hands and feet and graded them using the modified Steinbrocker score (mSS). Grades 0 and 1 were combined as a single state. We defined damage repair as a decrease in the joint-level mSS and summarized disease characteristics using descriptive statistics. We defined states based on the mSS and fitted multistate Markov models to estimate transition intensities and assess the impact of prognostic factors on damage repair. Results: We included 674 patients with PsA (54.7% male), with a mean age of 44.4 years (SD 12.8) and a mean disease duration of 6.3 years (SD 8.0) at baseline (clinic entry). Over a total follow-up of 7189.5 person-years, 428 patients (63.4%) developed at least one damaged joint (mSS ≥2) and 127 of them (29.7%) demonstrated evidence of repair in at least one joint. In total, 361 joints demonstrated radiographic improvement. Progression of damage was observed in patients prior to biologic DMARD therapy. Combination of methotrexate and biologic DMARDs was associated with a reduced progression rate for joint damage (RR = 0.48, 95% CI: 0.38-0.62) and an increased rate of damage repair (RR = 1.97, 95% CI: 1.13-3.45). Conclusion: Radiographic improvement consistent with damage repair is not infrequent in PsA. Concomitant treatment with biologic DMARDs and MTX is a predictor of slower radiographic progression and damage repair. (© The Author(s) 2026. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Grant Information: | Krembil Foundation and the Schroeder Arthritis Institute; Hospital-University Named Chair between the University of Toronto; University Health Network and the UHN Foundation |
| Contributed Indexing: | Keywords: damage; erosions; psoriatic arthritis; repair |
| Substance Nomenclature: | 0 (Antirheumatic Agents) |
| Entry Date(s): | Date Created: 20260520 Date Completed: 20260608 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1093/rheumatology/keag258 |
| PMID: | 42157419 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1462-0332 |
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| DOI: | 10.1093/rheumatology/keag258 |