Academic Journal
Promises of reprogramming-induced rejuvenation.
| Title: | Promises of reprogramming-induced rejuvenation. |
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| Authors: | Simpson DJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. Electronic address: https://twitter.com/@DanielJSimpson4., Arif N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA., Suwanlikit Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, USA; Department of Pharmacology, Faculty of Science, Mahidol University, Thailand., Kirschner K; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: kirschner.kristina@mayo.edu., Chandra T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. Electronic address: chandra.tamir@mayo.edu. |
| Source: | Current opinion in genetics & development [Curr Opin Genet Dev] 2026 Aug; Vol. 99, pp. 102484. Date of Electronic Publication: 2026 May 20. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Elsevier Original Publication: London, UK : Current Biology, c1991- |
| MeSH Terms: | Cellular Reprogramming*/genetics , Rejuvenation*/physiology , Cellular Senescence*/genetics, Epigenesis, Genetic/genetics ; Humans ; Animals |
| Abstract: | Reprogramming-induced rejuvenation (RIR) reverses cellular aging by transiently engaging early reprogramming states without full dedifferentiation. This review examines current developments in the molecular mechanisms, technological advances, and tissue-specific applications of RIR. Recent mechanistic insights highlight persisting questions in timing, heterogeneity, and pathways engaged in the epigenetic response. New technological advances have expanded RIR modalities beyond traditional Yamanaka factors to include mRNA-based delivery, CRISPRa, and chemical cocktails, while high-throughput screening platforms are systematically identifying novel rejuvenation factors with improved safety profiles. Recent tissue-specific applications demonstrate functional restoration across brain, liver, intestine, cardiovascular, and epithelial systems through reversal of cellular senescence, reduction of DNA damage and epigenetic age, and enhanced regenerative capacity. However, clinical translation faces challenges including narrow therapeutic windows, incomplete mechanistic understanding, and limited biomarker standardization. We discuss how single-cell technologies, computational prediction tools, and systematic in vivo testing may advance RIR toward geroscience therapies for age-related diseases. (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Entry Date(s): | Date Created: 20260519 Date Completed: 20260721 Latest Revision: 20260721 |
| Update Code: | 20260722 |
| DOI: | 10.1016/j.gde.2026.102484 |
| PMID: | 42155210 |
| Database: | MEDLINE |
| ISSN: | 1879-0380 |
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| DOI: | 10.1016/j.gde.2026.102484 |