Academic Journal
Cigarette smoking, history of major depression and PTSD diagnosis are associated with metabolite levels in the left dorsolateral prefrontal cortex in those in treatment for alcohol use disorder.
| Τίτλος: | Cigarette smoking, history of major depression and PTSD diagnosis are associated with metabolite levels in the left dorsolateral prefrontal cortex in those in treatment for alcohol use disorder. |
|---|---|
| Συγγραφείς: | Durazzo TC; War Related Illness and Injury Study Center, Palo Alto Veterans Affairs Healthcare System, 3801 Miranda Ave, Palo Alto, CA 94304, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA. Electronic address: tdurazzo@stanford.edu., Carolan RE; Sierra-Pacific Mental Illness Research and Education Clinical Centers, Palo Alto Veterans Affairs Healthcare System, 3801 Miranda Ave, Palo Alto, CA 94304, USA., Beauregard LH; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA., Gu M; Department of Radiology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA., Padula CB; Sierra-Pacific Mental Illness Research and Education Clinical Centers, Palo Alto Veterans Affairs Healthcare System, 3801 Miranda Ave, Palo Alto, CA 94304, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305, USA. |
| Πηγή: | Drug and alcohol dependence [Drug Alcohol Depend] 2026 Aug 01; Vol. 285, pp. 113194. Date of Electronic Publication: 2026 May 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 7513587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0046 (Electronic) Linking ISSN: 03768716 NLM ISO Abbreviation: Drug Alcohol Depend Subsets: MEDLINE |
| Imprint Name(s): | Publication: Limerick : Elsevier Original Publication: Lausanne, Elsevier Sequoia. |
| Ιατρικοί όροι (MeSH): | Stress Disorders, Post-Traumatic*/metabolism , Stress Disorders, Post-Traumatic*/complications , Stress Disorders, Post-Traumatic*/epidemiology , Cigarette Smoking*/metabolism , Major Depressive Disorder*/metabolism , Major Depressive Disorder*/complications , Major Depressive Disorder*/epidemiology , Alcoholism*/metabolism , Alcoholism*/complications , Alcoholism*/therapy , Dorsolateral Prefrontal Cortex*/metabolism , Prefrontal Cortex*/metabolism, Choline/metabolism ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Glutamic Acid/metabolism ; gamma-Aminobutyric Acid/metabolism ; Humans ; Male ; Female ; Middle Aged ; Adult ; Veterans ; Magnetic Resonance Spectroscopy |
| Περίληψη: | Background: Despite the known systemic health risks associated with cigarette smoking, research investigating the neurobiological consequences of smoking in those with alcohol use disorder (AUD) is minimal. This study compared metabolite levels in the left dorsolateral prefrontal cortex (DLPFC) in non-cigarette smoking individuals, former cigarette smoking individuals and active cigarette smoking individuals who were Veterans in residential treatment for AUD. Methods: Water scaled concentrations were obtained for N-acetylaspartate (NAA), choline-containing compounds (Cho) creatine-containing compounds (Cr), gamma-aminobutyric acid (GABA) and glutamate (Glu). Actively smoking AUD (AsAUD, n = 46) used cigarettes daily; former smoking AUD (FsAUD, n = 41) were predominately daily cigarette consumers prior to study, with variable lengths of cessation; non-smoking AUD (NsAUD, n = 32) never used cigarettes or seldomly smoked during lifetime. Given the high prevalence of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in Veterans with AUD, these conditions served as factors in all analyses. Results: AsAUD had lower NAA, Cho and Cr than NsAUD and lower Cr than FsAUD; there were no metabolite level differences between FsAUD and NsAUD. Individuals with no history of MDD showed lower NAA and Cho levels than those with current MDD and past MDD; current MDD and past MDD were not different on any metabolite concentration. Individuals with a current PTSD diagnosis demonstrated lower Cr level than those with no PTSD diagnosis. Conclusions: Results suggest that smoking, MDD and PTSD history are associated with left DLPFC brain metabolite concentrations during early AUD recovery. These novel findings also support the clinical practice of offering smoking cessation resources concurrent with AUD treatment. (Published by Elsevier B.V.) |
| Competing Interests: | Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Timothy C. Durazzo reports financial support was provided by VHA Office of Research & Development. Timothy C. Durazzo reports financial support was provided by Stanford University Wu Tsai Neurosciences Institute. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Alcohol use disorder; Cigarette smoking; Magnetic resonance spectroscopy; Major depressive disorder; Post-traumatic stress disorder |
| Substance Nomenclature: | N91BDP6H0X (Choline) 30KYC7MIAI (Aspartic Acid) 3KX376GY7L (Glutamic Acid) 56-12-2 (gamma-Aminobutyric Acid) 997-55-7 (N-acetylaspartate) |
| Entry Date(s): | Date Created: 20260518 Date Completed: 20260627 Latest Revision: 20260627 |
| Update Code: | 20260628 |
| DOI: | 10.1016/j.drugalcdep.2026.113194 |
| PMID: | 42150346 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0046 |
|---|---|
| DOI: | 10.1016/j.drugalcdep.2026.113194 |