Academic Journal
Advances in mosquito olfaction: Genetic, genomic, and behavioral approaches in Aedes aegypti.
| Τίτλος: | Advances in mosquito olfaction: Genetic, genomic, and behavioral approaches in Aedes aegypti. |
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| Συγγραφείς: | Hill TJ; Department of Biology, Boston University, Boston, MA, 02143, USA., Kohli G; Department of Biology, Boston University, Boston, MA, 02143, USA., Younger MA; Department of Biology, Boston University, Boston, MA, 02143, USA; Center for Systems Neuroscience, Boston University, Boston, MA, 02143, USA; Center for Neurophotonics, Boston University, Boston, MA, 02143, USA. Electronic address: myounger@bu.edu. |
| Πηγή: | Current opinion in neurobiology [Curr Opin Neurobiol] 2026 Aug; Vol. 99, pp. 103214. Date of Electronic Publication: 2026 May 18. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Current Biology Country of Publication: England NLM ID: 9111376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6882 (Electronic) Linking ISSN: 09594388 NLM ISO Abbreviation: Curr Opin Neurobiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, UK : Current Biology, c1991- |
| Ιατρικοί όροι (MeSH): | Aedes*/physiology , Aedes*/genetics , Smell*/physiology , Smell*/genetics , Behavior, Animal*/physiology , Genomics*, Animals |
| Περίληψη: | Mosquito behavior has long been studied because of its importance in the spread of human disease. More recently, mosquitoes have emerged as a model for studying olfaction, given their exquisite ability to locate human hosts. Host seeking unfolds through a series of behavioral phases, including activation, flight, landing, blood feeding, and oviposition, making it well suited for study across multiple levels. In this review, we focus on methodological advances that have shaped the study of mosquito host-seeking behavior, with a focus on the Yellow Fever mosquito, Aedes aegypti. We highlight three major areas of progress: (1) the development of behavioral platforms, including camera-based and automated tracking systems, to quantify distinct phases of behavior, (2) advances in genomic and transcriptomic resources that support molecular analysis of olfaction and behavior, and (3) the expansion of genetic tools for targeted manipulation and functional study of specific cell types and neural circuits. Insights from these studies enhance our understanding of a highly specialized olfactory system as well as serve as a basis for interventions against these deadly disease vectors. (Copyright © 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The declaration website was not working and kept coming back blank. I have no competing interests to declare. All funding sources are listed in the acknowledgements. |
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| Grant Information: | United Kingdom WT_ Wellcome Trust; DP2 HL185099 United States HL NHLBI NIH HHS |
| Entry Date(s): | Date Created: 20260518 Date Completed: 20260722 Latest Revision: 20260923 |
| Update Code: | 20260923 |
| PubMed Central ID: | PMC13220323 |
| DOI: | 10.1016/j.conb.2026.103214 |
| PMID: | 42150309 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-6882 |
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| DOI: | 10.1016/j.conb.2026.103214 |