Academic Journal
Ion interference and its combined therapies for cancer treatments.
| Τίτλος: | Ion interference and its combined therapies for cancer treatments. |
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| Συγγραφείς: | Hu X; Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK. ntk.thanh@ucl.ac.uk.; UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK., Guo D; Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK. ntk.thanh@ucl.ac.uk.; UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK., Thanh NTK; Biophysics Group, Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, UK. ntk.thanh@ucl.ac.uk.; UCL Healthcare Biomagnetics and Nanomaterials Laboratories, 21 Albemarle Street, London W1S 4BS, UK. |
| Πηγή: | Nanoscale [Nanoscale] 2026 Jul 02; Vol. 18 (25), pp. 13176-13198. Date of Electronic Publication: 2026 Jul 02. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: RSC Pub Country of Publication: England NLM ID: 101525249 Publication Model: Electronic Cited Medium: Internet ISSN: 2040-3372 (Electronic) Linking ISSN: 20403364 NLM ISO Abbreviation: Nanoscale Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cambridge, UK : RSC Pub. |
| Ιατρικοί όροι (MeSH): | Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/therapy , Neoplasms*/metabolism , Ions*/chemistry , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Nanostructures*/chemistry , Nanostructures*/therapeutic use, Tumor Microenvironment/drug effects ; Nanomedicine/methods ; Cell Survival/drug effects ; Humans ; Animals |
| Περίληψη: | Despite continuous advances in oncology, there remains a pressing need for tumour-specific therapies that can adapt to the unique tumour microenvironment while maintaining high efficacy and low systemic toxicity. Inspired by the critical role of ionic homeostasis in cancer cell survival, ion interference therapy has emerged as a strategy that exploits intracellular ions as cytotoxic effectors to selectively disrupt tumour viability. In particular, nano-engineered platforms enable precise manipulation of ion fluxes through ion-releasing nanomaterials, artificial nanochannels, and transporter-modulating systems, and can be readily integrated with conventional therapeutic modalities. By responding to a specific tumour microenvironment and metabolic imbalances, nano-enabled ion interference offers spatially confined and stimulus-responsive cytotoxicity, providing a promising framework for precision nanomedicine. |
| Substance Nomenclature: | 0 (Ions) 0 (Antineoplastic Agents) |
| Entry Date(s): | Date Created: 20260518 Date Completed: 20260702 Latest Revision: 20260702 |
| Update Code: | 20260702 |
| DOI: | 10.1039/d5nr04488j |
| PMID: | 42148931 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2040-3372 |
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| DOI: | 10.1039/d5nr04488j |