Academic Journal
Brain-wide information flow dynamics during novel visual processing in humans.
| Τίτλος: | Brain-wide information flow dynamics during novel visual processing in humans. |
|---|---|
| Συγγραφείς: | Huang W; Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China.; Department of Ophthalmology, Xinqiao Hospital, Third Military Medical University, Chongqing, China., Song J; Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China., Huangfu J; Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China., Liang S; Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing, China., Wang Z; Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China., Liao X; Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing, China., Zhang C; Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China., Chen X; Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing, China.; Chongqing Institute for Brain and Intelligence, Guangyang Bay Laboratory, Chongqing, China., Yuan R; Department of Ophthalmology, Xinqiao Hospital, Third Military Medical University, Chongqing, China. yuanrongdi@tmmu.edu.cn., Wang L; Department of Neurosurgery, Epilepsy Research Center of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China. lkwang2009@tmmu.edu.cn. |
| Πηγή: | Communications biology [Commun Biol] 2026 May 18; Vol. 9 (1). Date of Electronic Publication: 2026 May 18. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]- |
| Ιατρικοί όροι (MeSH): | Visual Perception*/physiology , Brain*/physiology, Visual Pathways/physiology ; Humans ; Female ; Adult ; Male ; Photic Stimulation ; Brain Mapping ; Young Adult ; Electroencephalography |
| Περίληψη: | The human brain's capacity for visual information processing is essential for higher-order cognitive functions, including facial recognition and spatial navigation. However, the millisecond-scale dynamics of cortico-subcortical information flow during novel visual stimulation remain unclear. To investigate this, we conducted intracranial electroencephalography (iEEG) recordings in 22 patients with refractory epilepsy as they underwent a picture-viewing task. Our findings showed region-specific modulations in high-frequency broadband (HFB, 60-160 Hz) activity across multiple brain regions, such as the dorsal and ventral visual streams, the limbic system, and higher-order cortical areas. Initial activation followed a hierarchical, back-to-front propagation pattern, starting from the primary visual areas, progressing through the ventral and dorsal streams, and ultimately engaging high-order cortical and limbic structures. Extensive top-down connectivity from higher-order cortex to limbic areas further revealed their role in novel visual processing, providing a high-resolution spatiotemporal map of visual information flow across brain regions. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
| References: | Cereb Cortex. 2022 Dec 20;33(2):330-356. (PMID: 35233615) Hippocampus. 2008;18(6):536-41. (PMID: 18446830) Neurosci Biobehav Rev. 2024 May;160:105650. (PMID: 38574782) Trends Neurosci. 1992 Jan;15(1):20-5. (PMID: 1374953) Neuroimage. 2014 Jan 15;85 Pt 2:711-20. (PMID: 24018305) Cereb Cortex. 2020 May 14;30(5):2961-2971. (PMID: 31821411) Annu Rev Psychol. 2018 Jan 4;69:105-129. (PMID: 28892638) Nat Commun. 2020 Jan 31;11(1):656. (PMID: 32005819) Front Hum Neurosci. 2020 Oct 09;14:561399. (PMID: 33192393) Front Neurosci. 2023 Aug 07;17:1206120. (PMID: 37609450) Hippocampus. 2023 May;33(5):533-572. (PMID: 36070199) J Neurosci. 2024 Apr 24;44(17):. (PMID: 38485257) J Neurosci. 2021 Jul 21;41(29):6314-6327. (PMID: 34099511) Curr Biol. 2019 Oct 21;29(20):3345-3358.e7. (PMID: 31588003) Brain. 2014 Aug;137(Pt 8):2231-44. (PMID: 24919972) Handb Clin Neurol. 2018;151:287-312. (PMID: 29519463) Nat Protoc. 2018 Jul;13(7):1699-1723. (PMID: 29988107) Neurosci Bull. 2024 Oct;40(10):1434-1444. (PMID: 38457111) Science. 2019 Aug 16;365(6454):. (PMID: 31416934) Brain. 2019 Nov 1;142(11):3502-3513. (PMID: 31501850) Cereb Cortex. 2024 Jul 3;34(7):. (PMID: 39042030) Clin Neurophysiol. 2024 Jun;162:9-27. (PMID: 38552414) Neuroimage. 2021 Dec 1;244:118608. (PMID: 34560270) Brain Res. 2023 Jul 1;1810:148370. (PMID: 37080267) Brain Struct Funct. 2024 Jul;229(6):1471-1493. (PMID: 38839620) Cereb Cortex. 2016 Aug;26(8):3563-3579. (PMID: 27235099) Sci China Life Sci. 2024 Mar;67(3):543-554. (PMID: 37957484) Science. 1969 Feb 28;163(3870):895-902. (PMID: 5763873) Cereb Cortex. 2023 Oct 9;33(20):10686-10701. (PMID: 37689834) Nat Rev Neurosci. 2012 May 18;13(6):407-20. (PMID: 22595786) Cereb Cortex. 2023 Mar 21;33(7):3319-3349. (PMID: 35834308) Neuron. 2012 Feb 9;73(3):415-34. (PMID: 22325196) Curr Biol. 2020 Jul 20;30(14):2707-2715.e3. (PMID: 32502406) Cereb Cortex. 2023 Aug 23;33(17):9764-9777. (PMID: 37464883) Commun Biol. 2026 May 18;9(1):. (PMID: 42144472) Nat Commun. 2017 Nov 3;8(1):1301. (PMID: 29101322) Nat Hum Behav. 2018 Jan;2(1):80-91. (PMID: 29963646) Cortex. 2022 Feb;147:83-101. (PMID: 35026557) Cereb Cortex. 2020 Oct 1;30(11):5972-5987. (PMID: 32572443) Cereb Cortex. 2020 Jun 1;30(7):4026-4043. (PMID: 32301963) Vision (Basel). 2019 Feb 10;3(1):. (PMID: 31735809) Clin Neurophysiol. 2008 Jan;119(1):116-33. (PMID: 18037343) Brain Sci. 2023 Feb 18;13(2):. (PMID: 36831897) Cell. 2021 Sep 2;184(18):4626-4639.e13. (PMID: 34411517) |
| Grant Information: | 82171463 National Natural Science Foundation of China (National Science Foundation of China) |
| Entry Date(s): | Date Created: 20260517 Date Completed: 20260806 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13443792 |
| DOI: | 10.1038/s42003-026-10262-4 |
| PMID: | 42144472 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2399-3642 |
|---|---|
| DOI: | 10.1038/s42003-026-10262-4 |