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Neuroelectrophysiological effects of Wuqinxi exercise on reactive inhibition deficits in Parkinson's disease.

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Title: Neuroelectrophysiological effects of Wuqinxi exercise on reactive inhibition deficits in Parkinson's disease.
Authors: Wang Z; School of Sport and Health Science, Xi'an Physical Education University, Xi'an, China; School of Psychology, Shanghai University of Sport, Shanghai, China., Li Y; School of Psychology, Shanghai University of Sport, Shanghai, China; Department of Chinese Medicine Nursing, School of Nursing, Anhui University of Chinese Medicine, Hefei, China., Wei J; Henan University of Science and Technology Sports Institute, Luoyang, China., Song Y; School of Psychology, Shanghai University of Sport, Shanghai, China., Chen J; School of Psychology, Shanghai University of Sport, Shanghai, China., Tan X; Faculty of Health Sciences and Sports, Macao Polytechnic University, Rua de Luis Gonzaga Gomes, Macao Special Administrative Region of China., Zhang J; School of Psychology, Shanghai University of Sport, Shanghai, China. Electronic address: zhangjian@sus.edu.cn.
Source: Psychology of sport and exercise [Psychol Sport Exerc] 2026 Sep; Vol. 86, pp. 103162. Date of Electronic Publication: 2026 May 16.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Language: English
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101088724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5476 (Electronic) Linking ISSN: 18785476 NLM ISO Abbreviation: Psychol Sport Exerc Subsets: MEDLINE
Imprint Name(s): Original Publication: [Amsterdam ; New York : Elsevier
MeSH Terms: Parkinson Disease*/physiopathology , Parkinson Disease*/therapy , Parkinson Disease*/psychology , Motor Cortex*/physiopathology , Motor Cortex*/physiology , Exercise Therapy*/methods , Reactive Inhibition*, Reaction Time/physiology ; Dorsolateral Prefrontal Cortex/physiopathology ; Dorsolateral Prefrontal Cortex/physiology ; Humans ; Female ; Male ; Aged ; Transcranial Magnetic Stimulation ; Middle Aged
Abstract: Objective: Motor inhibition deficits in Parkinson's disease (PD) are linked to functional alterations in the frontal-basal ganglia circuit, notably excessive interhemispheric inhibition from the right dorsolateral prefrontal cortex (DLPFC) onto the left primary motor cortex (M1). Although Wuqinxi-a traditional Chinese exercise-has been shown to ameliorate motor symptoms in PD, its potential to remediate motor inhibition impairments via modulation of cortical interhemispheric interactions remains unresolved.
Methods: Forty-seven PD patients were randomly assigned to either a Wuqinxi group or a stretching control group for a 24-week intervention, completing 90mins sessions three times per week. We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to combine stop-signal tasks to examine the electrophysiological and motor inhibition changes pre and post intervention.
Results: Compared with pre-intervention measures, PD patients in the Wuqinxi group exhibited a significant reduction in interhemispheric inhibitory interaction between the right DLPFC and left M1, concomitant with a pronounced decrease in stop signal reaction time (SSRT).
Conclusions: 24 weeks of Wuqinxi practice attenuate excessive interhemispheric inhibition from the right DLPFC to the left M1 in PD patients, thereby alleviating impaired reactive inhibition capacity.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Dorsolateral prefrontal cortex; Interhemispheric interaction; Motor inhibition; Primary motor cortex; Stop signal reaction time
Entry Date(s): Date Created: 20260516 Date Completed: 20260722 Latest Revision: 20260903
Update Code: 20260904
DOI: 10.1016/j.psychsport.2026.103162
PMID: 42142853
Database: MEDLINE
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  Data: Neuroelectrophysiological effects of Wuqinxi exercise on reactive inhibition deficits in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; School of Sport and Health Science, Xi'an Physical Education University, Xi'an, China; School of Psychology, Shanghai University of Sport, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; School of Psychology, Shanghai University of Sport, Shanghai, China; Department of Chinese Medicine Nursing, School of Nursing, Anhui University of Chinese Medicine, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Henan University of Science and Technology Sports Institute, Luoyang, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; School of Psychology, Shanghai University of Sport, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; School of Psychology, Shanghai University of Sport, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tan+X%22">Tan X</searchLink>; Faculty of Health Sciences and Sports, Macao Polytechnic University, Rua de Luis Gonzaga Gomes, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; School of Psychology, Shanghai University of Sport, Shanghai, China. Electronic address: zhangjian@sus.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101088724%22">Psychology of sport and exercise</searchLink> [Psychol Sport Exerc] 2026 Sep; Vol. 86, pp. 103162. <i>Date of Electronic Publication: </i>2026 May 16.
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  Data: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101088724 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-5476 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218785476%22">18785476 </searchLink><i>NLM ISO Abbreviation: </i>Psychol Sport Exerc <i>Subsets: </i>MEDLINE
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  Data: <i>Original Publication</i>: [Amsterdam ; New York : Elsevier
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  Data: <searchLink fieldCode="MM" term="%22Parkinson+Disease%22">Parkinson Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Parkinson+Disease+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Parkinson+Disease%22">Parkinson Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Parkinson+Disease+therapy%22">therapy</searchLink> <br /><searchLink fieldCode="MM" term="%22Parkinson+Disease%22">Parkinson Disease*</searchLink>/<searchLink fieldCode="MM" term="%22Parkinson+Disease+psychology%22">psychology</searchLink> <br /><searchLink fieldCode="MM" term="%22Motor+Cortex%22">Motor Cortex*</searchLink>/<searchLink fieldCode="MM" term="%22Motor+Cortex+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Motor+Cortex%22">Motor Cortex*</searchLink>/<searchLink fieldCode="MM" term="%22Motor+Cortex+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Exercise+Therapy%22">Exercise Therapy*</searchLink>/<searchLink fieldCode="MM" term="%22Exercise+Therapy+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Reactive+Inhibition%22">Reactive Inhibition*</searchLink><br /><searchLink fieldCode="MH" term="%22Reaction+Time%22">Reaction Time</searchLink>/<searchLink fieldCode="MH" term="%22Reaction+Time+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Dorsolateral+Prefrontal+Cortex%22">Dorsolateral Prefrontal Cortex</searchLink>/<searchLink fieldCode="MH" term="%22Dorsolateral+Prefrontal+Cortex+physiopathology%22">physiopathology</searchLink> ; <searchLink fieldCode="MH" term="%22Dorsolateral+Prefrontal+Cortex%22">Dorsolateral Prefrontal Cortex</searchLink>/<searchLink fieldCode="MH" term="%22Dorsolateral+Prefrontal+Cortex+physiology%22">physiology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Transcranial+Magnetic+Stimulation%22">Transcranial Magnetic Stimulation</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Motor inhibition deficits in Parkinson's disease (PD) are linked to functional alterations in the frontal-basal ganglia circuit, notably excessive interhemispheric inhibition from the right dorsolateral prefrontal cortex (DLPFC) onto the left primary motor cortex (M1). Although Wuqinxi-a traditional Chinese exercise-has been shown to ameliorate motor symptoms in PD, its potential to remediate motor inhibition impairments via modulation of cortical interhemispheric interactions remains unresolved.<br />Methods: Forty-seven PD patients were randomly assigned to either a Wuqinxi group or a stretching control group for a 24-week intervention, completing 90mins sessions three times per week. We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to combine stop-signal tasks to examine the electrophysiological and motor inhibition changes pre and post intervention.<br />Results: Compared with pre-intervention measures, PD patients in the Wuqinxi group exhibited a significant reduction in interhemispheric inhibitory interaction between the right DLPFC and left M1, concomitant with a pronounced decrease in stop signal reaction time (SSRT).<br />Conclusions: 24 weeks of Wuqinxi practice attenuate excessive interhemispheric inhibition from the right DLPFC to the left M1 in PD patients, thereby alleviating impaired reactive inhibition capacity.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Dorsolateral prefrontal cortex; Interhemispheric interaction; Motor inhibition; Primary motor cortex; Stop signal reaction time
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  Data: <i>Date Created: </i>20260516 <i>Date Completed: </i>20260722 <i>Latest Revision: </i>20260903
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  Data: 10.1016/j.psychsport.2026.103162
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        Value: 10.1016/j.psychsport.2026.103162
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        Text: English
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        StartPage: 103162
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        Type: general
      – SubjectFull: Dorsolateral Prefrontal Cortex physiopathology
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      – SubjectFull: Dorsolateral Prefrontal Cortex physiology
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        Type: general
      – SubjectFull: Parkinson Disease psychology
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      – SubjectFull: Motor Cortex physiopathology
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      – SubjectFull: Motor Cortex physiology
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      – SubjectFull: Exercise Therapy methods
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      – SubjectFull: Reactive Inhibition
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      – TitleFull: Neuroelectrophysiological effects of Wuqinxi exercise on reactive inhibition deficits in Parkinson's disease.
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              Text: 2026 Sep
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