Academic Journal
Persistence and dynamics of antibiotic resistance genes in livestock manure during anaerobic digestion.
| Title: | Persistence and dynamics of antibiotic resistance genes in livestock manure during anaerobic digestion. |
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| Authors: | Pan Z; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China., Ngoc MN; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium., Xie Z; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China., Wang Q; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China., Wang J; Engineering Research Center of Soil Remediation of Fujian Province University, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Chen X; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China., Chen C; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China., Lin Q; China-Croatia Belt and Road Joint Laboratory on Biodiversity and Ecosystem Services, Agricultural Microbial Agents Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China. Electronic address: linqiang@cib.ac.cn. |
| Source: | Waste management (New York, N.Y.) [Waste Manag] 2026 Jun 30; Vol. 220, pp. 115590. Date of Electronic Publication: 2026 May 17. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Pergamon Press Country of Publication: United States NLM ID: 9884362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2456 (Electronic) Linking ISSN: 0956053X NLM ISO Abbreviation: Waste Manag Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York : Pergamon Press, c1989- |
| MeSH Terms: | Manure*/microbiology , Drug Resistance, Microbial*/genetics, Animals ; Anaerobiosis ; Livestock ; Genes, Bacterial |
| Abstract: | Livestock manure is a primary reservoir of antibiotic resistance genes, and anaerobic digestion is widely employed for its treatment. However, the reduction efficiencies of antibiotic resistance genes during anaerobic digestion vary drastically across studies, and the underlying mechanisms remain obscured by microbial complexity. This work systematically reviews the persistence and dynamics of antibiotic resistance genes in livestock manure anaerobic digestion through the lens of ecological community assembly, specifically examining the tradeoff between deterministic processes (e.g., temperature and pH filtering) andstochastic processes(e.g., microbial immigration and drift). We identify that microbial community diversity and interspecies interactions (cooperation vs. competition) play dual roles: high diversity can act as a barrier to antibiotic resistance gene invasion but also increases the range of potential horizontal gene transfer recipients. Furthermore, the role of viruses is re-evaluated, suggesting that their contribution to host lysis likely outweighs transduction in stable anaerobic digestion systems. By synthesizing evidence from manure-specific studies and bridging mechanistic gaps with fundamental anaerobic digestion microbiology, this review proposes that effective antibiotic resistance gene control requires shifting from simple parameter adjustment to the precise regulation of ecological niches, thereby minimizing environmental dissemination risks. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anaerobic digestion; Antibiotic resistance genes; Livestock manure; Microbial mechanisms |
| Substance Nomenclature: | 0 (Manure) |
| Entry Date(s): | Date Created: 20260516 Date Completed: 20260610 Latest Revision: 20260610 |
| Update Code: | 20260611 |
| DOI: | 10.1016/j.wasman.2026.115590 |
| PMID: | 42142453 |
| Database: | MEDLINE |
| ISSN: | 1879-2456 |
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| DOI: | 10.1016/j.wasman.2026.115590 |