Academic Journal
Προβολή σε EDS

Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Genetic variants in the leptin-melanocortin pathway and their joint effects with physical activity and sleep duration on risk of childhood obesity.
Συγγραφείς: Liang X; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Pan S; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Ji J; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Deng Y; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Chen M; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Huang Z; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Deng J; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Chen M; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China., Xiong T; Department of Occupational Health, Shenzhen Bao'an District Public Health Center, Shenzhen, China‌‌., Liang J; Department of School Health, Guangzhou Health Care Promotion Center for Primary and Middle Schools, Guangzhou, China., Liu L; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Πηγή: PloS one [PLoS One] 2026 May 15; Vol. 21 (5), pp. e0348694. Date of Electronic Publication: 2026 May 15 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Imprint Name(s): Original Publication: San Francisco, CA : Public Library of Science
Ιατρικοί όροι (MeSH): Leptin*/genetics , Leptin*/metabolism , Pediatric Obesity*/genetics , Melanocortins*/genetics , Melanocortins*/metabolism , Exercise*, Receptors, Leptin/genetics ; Receptor, Melanocortin, Type 4/genetics ; Pro-Opiomelanocortin/genetics ; Humans ; Child ; Case-Control Studies ; Female ; Adolescent ; Male ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Sleep Duration ; Genetic Risk Score ; Genetic Variation ; Risk Factors ; Sleep
Περίληψη: Objective: This study aimed to investigate the associations between functional genetic variants in leptin-melanocortin pathway and risk of childhood obesity, as well as exploring gene-lifestyle interactions on obesity risk.
Methods: A frequency-matched case-control study included 1123 children and adolescents with obesity and 1231 controls from Guangzhou, China. Twelve potentially functional genetic variants were genotyped. Multivariate logistic regression and classification and regression tree were applied to identify obesity-associated genetic variants. Unweighted and weighted genetic risk scores (GRSs) were constructed, and their interactions with physical activity and sleep were assessed using relative excess risk of interaction (RERI), attributable proportion of interaction (AP) and the interaction of odds ratio (IOR).
Results: We identified important genetic variants associated with obesity: MC4R rs17782313, rs12970134, LEPR rs1137101, and POMC rs6713532. High unweighted GRS was associated with a higher obesity risk than low GRS (OR = 1.40, 95% CI = 1.09-1.79), with similar results for the weighted GRS. High unweighted GRS combined with inadequate sleep or physical activity conferred increased risk of obesity compared to low/medium GRS with healthy lifestyle (OR = 1.70, 95% CI = 1.28-2.26; OR = 1.59, 95% CI = 1.17-2.17). However, the 95% CIs for all RERIs and APs contained 0, and for IORs contained 1, suggesting no significant interaction.
Conclusions: Four genetic variants in the leptin-melanocortin pathway are associated with the risk of obesity, both individually and jointly. Furthermore, the joint effect of these genetic variants with inadequate sleep and physical activity may contribute to obesity development in children and adolescents.
(Copyright: © 2026 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Competing Interests: The authors have declared that no competing interests exist.
References: Diabetes. 2010 Dec;59(12):3085-9. (PMID: 20843981)
Epidemiology. 1996 May;7(3):286-90. (PMID: 8728443)
Nucleic Acids Res. 2016 Jan 4;44(D1):D877-81. (PMID: 26657631)
Zhonghua Liu Xing Bing Xue Za Zhi. 2023 Mar 10;44(3):511-515. (PMID: 36942350)
Diabetes Metab Res Rev. 2024 Feb;40(2):e3667. (PMID: 37269143)
Science. 2020 Sep 11;369(6509):1318-1330. (PMID: 32913098)
Nat Rev Genet. 2009 Jul;10(7):431-42. (PMID: 19506576)
Eur J Pharmacol. 2011 Jun 11;660(1):220-5. (PMID: 21211529)
Neuron. 1999 Sep;24(1):155-63. (PMID: 10677034)
Ann Epidemiol. 2007 Mar;17(3):227-36. (PMID: 17320789)
Int J Obes Suppl. 2014 Jul;4(Suppl 1):S37-44. (PMID: 27152165)
Mol Carcinog. 2021 Sep;60(9):620-626. (PMID: 34133796)
Prog Mol Biol Transl Sci. 2013;114:109-46. (PMID: 23317784)
Nature. 2001 May 24;411(6836):480-4. (PMID: 11373681)
Front Endocrinol (Lausanne). 2022 Apr 29;13:832911. (PMID: 35574020)
Int J Obes (Lond). 2019 Aug;43(8):1556-1567. (PMID: 31285522)
Prog Mol Biol Transl Sci. 2013;114:147-91. (PMID: 23317785)
Genet Mol Res. 2015 Aug 07;14(3):9136-44. (PMID: 26345846)
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Oct;36(10):1062-4. (PMID: 26837344)
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Feb 28;57:11-19. (PMID: 36854438)
Lancet Diabetes Endocrinol. 2018 Mar;6(3):223-236. (PMID: 28919064)
Hum Mol Genet. 2010 May 1;19(9):1846-55. (PMID: 20167575)
Nucleic Acids Res. 2019 Jan 8;47(D1):D1005-D1012. (PMID: 30445434)
Stat Med. 2005 Mar 15;24(5):693-708. (PMID: 15515134)
Mol Genet Metab. 2012 May;106(1):121-6. (PMID: 22463805)
Diabetologia. 2017 May;60(5):778-783. (PMID: 28013339)
Metabolism. 2019 Nov;100S:153942. (PMID: 31610854)
Nat Rev Genet. 2022 Feb;23(2):120-133. (PMID: 34556834)
Metabolism. 2019 Mar;92:147-152. (PMID: 30529454)
PLoS One. 2017 Jan 12;12(1):e0170062. (PMID: 28081251)
Int J Public Health. 2012 Feb;57(1):243-6. (PMID: 22015650)
Substance Nomenclature: 0 (Leptin)
0 (Receptors, Leptin)
0 (Receptor, Melanocortin, Type 4)
0 (Melanocortins)
66796-54-1 (Pro-Opiomelanocortin)
0 (LEPR protein, human)
Entry Date(s): Date Created: 20260515 Date Completed: 20260716 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13178977
DOI: 10.1371/journal.pone.0348694
PMID: 42139370
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1932-6203
DOI:10.1371/journal.pone.0348694