Academic Journal
3D Probe-Based Chemoproteomic Profiling Enables the Discovery of a Polyphenol Oxidase Catalyzing Oxidative Lactonization of Salvianolic Acid B.
| Τίτλος: | 3D Probe-Based Chemoproteomic Profiling Enables the Discovery of a Polyphenol Oxidase Catalyzing Oxidative Lactonization of Salvianolic Acid B. |
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| Συγγραφείς: | Xu ZZ; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Zhuang Z; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Yan H; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Wu S; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., Zhao Q; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China., He QL; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China. |
| Πηγή: | Organic letters [Org Lett] 2026 May 29; Vol. 28 (21), pp. 6607-6612. Date of Electronic Publication: 2026 May 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, DC : American Chemical Society, c1999- |
| Ιατρικοί όροι (MeSH): | Benzofurans*/chemistry , Benzofurans*/metabolism , Salvia miltiorrhiza*/enzymology , Salvia miltiorrhiza*/chemistry , Catechol Oxidase*/metabolism , Catechol Oxidase*/chemistry, Depsides ; Molecular Structure ; Oxidation-Reduction |
| Περίληψη: | Chemoproteomic profiling provides a complementary approach for linking natural products to their corresponding enzymes. A previously unrecognized polyphenol oxidase, SmPPOA, was identified from Salvia miltiorrhiza using a 3D carbene-immobilized salvianolic acid B. SmPPOA catalyzes oxidative lactonization of salvianolic acid B to generate salvianolic acid O via a cascade of oxidation and intramolecular Michael addition using the carboxylate anion as the Michael donor. This strategy can facilitate discovery of biosynthetic enzymes for plant natural products. |
| Substance Nomenclature: | 0 (Benzofurans) 0 (Depsides) C1GQ844199 (salvianolic acid B) EC 1.10.3.1 (Catechol Oxidase) |
| Entry Date(s): | Date Created: 20260515 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1021/acs.orglett.6c01452 |
| PMID: | 42138061 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1523-7052 |
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| DOI: | 10.1021/acs.orglett.6c01452 |