Academic Journal
Amino acid metabolism at the senescence-cancer interface.
| Τίτλος: | Amino acid metabolism at the senescence-cancer interface. |
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| Συγγραφείς: | Lori G; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy., Mancini C; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy., Pranzini E; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy. Electronic address: erica.pranzini@unifi.it., Magherini F; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, Florence 50134, Italy. Electronic address: francesca.magherini@unifi.it., Taddei ML; Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, Florence 50134, Italy. |
| Πηγή: | Trends in cancer [Trends Cancer] 2026 Aug; Vol. 12 (8), pp. 741-754. Date of Electronic Publication: 2026 May 14. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cell Press Country of Publication: United States NLM ID: 101665956 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-8025 (Electronic) Linking ISSN: 24058025 NLM ISO Abbreviation: Trends Cancer Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Cambridge, MA] : Cell Press, [2015]- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/immunology , Cellular Senescence*/drug effects , Amino Acids*/metabolism , Neoplasms*/pathology , Neoplasms*/metabolism , Neoplasms*/immunology , Neoplasms*/drug therapy, Tumor Microenvironment/immunology ; Tumor Microenvironment/drug effects ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Humans ; Metabolic Reprogramming ; Animals |
| Περίληψη: | Amino acid (AA) metabolism plays a fundamental role in the regulation of cellular senescence. Through profound AA metabolic reprogramming, senescent stromal cells can sustain tumor progression, metastatic dissemination, and the establishment of an immunoevasive microenvironment. Conversely, alterations in AA availability within the tumor microenvironment can enforce tumor-suppressive senescence in malignant cells. In this review, we discuss how senescence-driven rewiring of AA metabolism shapes tumor-stroma interactions and immune responses. We propose that AA-targeted interventions may represent an effective therapeutic strategy to simultaneously mitigate the detrimental effects of stromal senescence while inducing tumor-suppressive senescence in cancer cells. (Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of interests The authors declare no competing interests. |
| Contributed Indexing: | Keywords: amino acid metabolism; cellular senescence; immunoevasion; metastatic colonization; tumor microenvironment |
| Substance Nomenclature: | 0 (Amino Acids) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20260811 Latest Revision: 20260811 |
| Update Code: | 20260812 |
| DOI: | 10.1016/j.trecan.2026.04.007 |
| PMID: | 42135087 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2405-8025 |
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| DOI: | 10.1016/j.trecan.2026.04.007 |