Academic Journal
A wearable electrochemical sensor for sweat cortisol detection based on molecularly imprinted polymer nanoparticles and cellulose nanofiber/carbon nanotube conductive aerogel.
| Τίτλος: | A wearable electrochemical sensor for sweat cortisol detection based on molecularly imprinted polymer nanoparticles and cellulose nanofiber/carbon nanotube conductive aerogel. |
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| Συγγραφείς: | Ming Z; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Zhao X; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Gu C; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Qin W; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Jiang Z; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Zhang X; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China., Wang Y; Tianjin Key Laboratory of Quantum Optics and Intelligent Photonics, School of Science, Tianjin University of Technology, Tianjin, 300384, China., Yin S; School of Materials Science and Engineering, Key Laboratory of Display Materials and Photoelectric Devices, Tianjin Key Laboratory for Photoelectric Materials and Devices, Ministry of Education, Tianjin University of Technology, Tianjin, 300384, China. sgyin@tjut.edu.cn. |
| Πηγή: | Mikrochimica acta [Mikrochim Acta] 2026 May 14; Vol. 193 (6). Date of Electronic Publication: 2026 May 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Wien ; New York : Springer-Verlag. |
| Ιατρικοί όροι (MeSH): | Hydrocortisone*/analysis , Hydrocortisone*/chemistry , Sweat*/chemistry , Electrochemical Techniques*/instrumentation , Electrochemical Techniques*/methods , Molecularly Imprinted Polymers*/chemistry , Nanotubes, Carbon*/chemistry , Nanofibers*/chemistry , Nanoparticles*/chemistry , Wearable Electronic Devices*, Cellulose/chemistry ; Aerogels/chemistry ; Metal Nanoparticles/chemistry ; Gold/chemistry ; Biosensing Techniques/methods ; Ferrocyanides/chemistry ; Humans ; Limit of Detection ; Molecular Imprinting |
| Περίληψη: | Sensitive, non-invasive detection of the steroid hormone cortisol aids in preventing chronic diseases such as depression and anxiety caused by stress. This study presents the development of a novel sweat cortisol sensor, integrating core-shell structured molecularly imprinted polymer (MIP) nanoparticles with a three-dimensional conductive aerogel to enable efficient, non-invasive monitoring of stress-related cortisol levels. This sensor leverages the large specific surface area and conductive network of aerogel to enhance electron transport efficiency and sensor sensitivity. The MIP nanoparticles are engineered with a gold nanoparticle-modified Prussian blue analogue core, providing stable redox activity and optimizing electrochemical performance. The sensor exhibits an extensive detection range from 10 pM to 100 µM and a remarkably low detection limit of 4.36 × 10- 12 M, alongside selectivity against other interfering substances. Screen printing technology was employed to fabricate the sensor into a wearable form, validating its stable detection performance and paving the way for mass production and practical applications. This research effectively addresses the limitations of conventional cortisol detection methods, offering a novel approach for real-time dynamic monitoring of stress-related physiological indicators, with significant implications for mental health surveillance and disease prevention. (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethics statement: The human sweat collection experiment was approved by the Ethics Committee of Tianjin University of Technology, and informed consent was obtained from the volunteer prior to participation. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 2018ZD09 Tianjin Key Discipline of Material Physics and Chemistry and Scientific Developing Foundation of Tianjin Education Commission |
| Contributed Indexing: | Keywords: Aerogel; Cortisol; Molecularly imprinted polymer; Screen printing; Electrochemical detection; Cyclic voltammetry; Nanoparticles |
| Substance Nomenclature: | WI4X0X7BPJ (Hydrocortisone) 0 (Molecularly Imprinted Polymers) 0 (Nanotubes, Carbon) 9004-34-6 (Cellulose) 0 (Aerogels) 7440-57-5 (Gold) 0 (Ferrocyanides) |
| Entry Date(s): | Date Created: 20260514 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1007/s00604-026-08106-3 |
| PMID: | 42133086 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1436-5073 |
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| DOI: | 10.1007/s00604-026-08106-3 |