Academic Journal
Elevated blood viscosity in thyroid-associated ophthalmopathy and its association with thyroid-stimulating immunoglobulin levels.
| Title: | Elevated blood viscosity in thyroid-associated ophthalmopathy and its association with thyroid-stimulating immunoglobulin levels. |
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| Authors: | Lee JE; Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Park J; Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Cho WK; Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Paik JS; Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Yang SW; Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. yswoph@hanmail.net. |
| Source: | Scientific reports [Sci Rep] 2026 May 13; Vol. 16 (1). Date of Electronic Publication: 2026 May 13. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| MeSH Terms: | Graves Ophthalmopathy*/blood , Graves Ophthalmopathy*/immunology , Blood Viscosity*, Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Case-Control Studies |
| Abstract: | Elevated blood viscosity (BV) is a key factor in vascular diseases; however, its role in thyroid-associated ophthalmopathy (TAO) and its association with autoimmune activity remain unclear. This study examined the relationship between BV, thyroid-stimulating immunoglobulin (TSI) levels, and clinical parameters in TAO. Specifically, we measured the systolic BV (SBV) and diastolic BV (DBV) of 70 patients with TAO and 48 controls using a scanning capillary tube viscometer and examined the correlation between BV and clinical and laboratory markers. Patients with TAO were stratified according to the median BV to assess the differences in TSI and thyroid function markers. Patients with TAO had significantly higher median SBV (p = 0.028) and DBV (p = 0.006) than those in the control group. BV correlated positively with TSI (rho = 0.241, p = 0.044 for SBV; rho = 0.239, p = 0.046 for DBV). T3 showed a weak positive correlation in univariable analysis; however, in multivariable analy`sis, only TSI remained significantly associated with SBV (p = 0.019) and DBV (p = 0.015). TAO was associated with elevated systemic BV, likely related to autoimmune activity and largely explained by hematologic parameters. These findings highlight the interplay between autoimmunity, hematology, and blood rheology. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethics declarations: The study protocol was approved by the Institutional Review Board of Seoul St. Mary’s Hospital (KC25RISI0203) on 4 April 2025. All procedures were conducted in accordance with the principles of the Declaration of Helsinki. Consent to participate: The requirement for written informed consent was waived due to the retrospective nature of the study and the use of anonymized data. |
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| Contributed Indexing: | Keywords: Autoimmunity; Blood viscosity; Clinical activity score; Thyroid-associated ophthalmopathy; Thyroid-stimulating immunoglobulin |
| Entry Date(s): | Date Created: 20260513 Date Completed: 20260714 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13365443 |
| DOI: | 10.1038/s41598-026-51839-7 |
| PMID: | 42129414 |
| Database: | MEDLINE |
| ISSN: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-026-51839-7 |