Academic Journal
Discovery of acyclic purine nucleosides as promising antiviral agents against dengue virus.
| Τίτλος: | Discovery of acyclic purine nucleosides as promising antiviral agents against dengue virus. |
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| Συγγραφείς: | Mondal SK; Indian Institute of Technology Bhubaneswar, Department of Chemistry, Jatni, Khordha, Odisha 752050, India., Samantaray S; Institute of Life Sciences (ILS), Department of Biotechnology, NALCO Nagar, Bhubaneswar, Odisha 751023, India., Sahoo AS; Institute of Life Sciences (ILS), Department of Biotechnology, NALCO Nagar, Bhubaneswar, Odisha 751023, India., Mohapatra A; Thapar Institute of Engineering and Technology (TIET), School of Chemistry and Biochemistry, Patiala 147004, Punjab, India., Syed GH; Institute of Life Sciences (ILS), Department of Biotechnology, NALCO Nagar, Bhubaneswar, Odisha 751023, India. Electronic address: gulamsyed@ils.res.in., Pal S; Indian Institute of Technology Bhubaneswar, Department of Chemistry, Jatni, Khordha, Odisha 752050, India. Electronic address: spal@iitbbs.ac.in. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Aug 15; Vol. 178, pp. 109961. Date of Electronic Publication: 2026 May 09. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Antiviral Agents*/chemical synthesis , Dengue Virus*/drug effects , Purine Nucleosides*/pharmacology , Purine Nucleosides*/chemistry , Purine Nucleosides*/chemical synthesis , Drug Discovery*, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Microbial Sensitivity Tests ; Dose-Response Relationship, Drug |
| Περίληψη: | Dengue virus (DENV) remains a significant global health challenge as one of the most prevalent mosquito-borne viral infections, with no specific antiviral therapy currently approved. Acyclic purine nucleosides have demonstrated as broad-spectrum antiviral activity by interfering with viral genome replication. Therefore, in this study, we designed a new series of d-glucose-derived acyclic purine nucleoside analogues (5a-f, 6a-c, and 8a-b), and evaluated their inhibitory activity against DENV serotype 2 (DENV2) using an in vitro Huh-7 cell-based assay. Among the library, analogue 5e exhibited the strongest antiviral profile, displaying a CC (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: ADMET prediction; Acyclic purine nucleosides; Dengue virus; Docking studies; Molecular dynamics simulation |
| Substance Nomenclature: | 0 (Antiviral Agents) 0 (Purine Nucleosides) |
| Entry Date(s): | Date Created: 20260513 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.bioorg.2026.109961 |
| PMID: | 42127740 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.109961 |