Academic Journal
Impaired growth after immunization with a bivalent oil-adjuvanted vaccine occurs without detectable changes to aerobic capacity in juvenile rainbow trout.
| Τίτλος: | Impaired growth after immunization with a bivalent oil-adjuvanted vaccine occurs without detectable changes to aerobic capacity in juvenile rainbow trout. |
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| Συγγραφείς: | Wallbom N; Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 413 90 Gothenburg, Sweden. Electronic address: nicklas.wallbom@bioenv.gu.se., Khansari AR; Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 413 90 Gothenburg, Sweden. Electronic address: ali.reza.khansari@slu.se., Sandblom E; Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 413 90 Gothenburg, Sweden. Electronic address: erik.sandblom@bioenv.gu.se., Sundh H; Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 413 90 Gothenburg, Sweden. Electronic address: henrik.sundh@bioenv.gu.se., Jönsson E; Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 7B, 413 90 Gothenburg, Sweden. Electronic address: elisabeth.jonsson@bioenv.gu.se. |
| Πηγή: | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology [Comp Biochem Physiol A Mol Integr Physiol] 2026 Jul; Vol. 317, pp. 112014. Date of Electronic Publication: 2026 May 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 9806096 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4332 (Electronic) Linking ISSN: 10956433 NLM ISO Abbreviation: Comp Biochem Physiol A Mol Integr Physiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, : Elsevier Science, c1998- |
| Ιατρικοί όροι (MeSH): | Oncorhynchus mykiss*/growth & development , Oncorhynchus mykiss*/immunology , Oncorhynchus mykiss*/metabolism , Adjuvants, Vaccine* , Adjuvants, Immunologic* , Mineral Oil*, Insulin-Like Growth Factor I/metabolism ; Growth Hormone/metabolism ; Animals ; Oxygen Consumption ; Vaccination ; Aerobiosis ; Immunization |
| Περίληψη: | The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard metabolic rate and inhibits growth through changes in the growth hormone-insulin-like growth factor I system in rainbow trout (Oncorhynchus mykiss). These effects were predicted to be long-lasting due to antigen deposition in the adjuvant. To test these hypotheses, we compared whole-animal oxygen uptake and endocrine growth regulation in vaccinated and unvaccinated rainbow trout at 14- and 54 days post injection. Contrary to our initial hypothesis, vaccination did not affect aerobic metabolism at any point in the experiment. However, our data indicate that vaccination inhibited length growth without affecting feed intake, which appeared to be mediated through reduced production of insulin-like growth factor I. In conclusion, our data agree with previous research showing that immune function is energetically cheap in rainbow trout and indicate that reduced growth after vaccination is decoupled from aerobic capacity. (Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no competing interests. |
| Contributed Indexing: | Keywords: Endocrine; Immune; Metabolic rate; Salmonid; Somatotropic |
| Substance Nomenclature: | 67763-96-6 (Insulin-Like Growth Factor I) 9002-72-6 (Growth Hormone) 0 (Adjuvants, Vaccine) 0 (Adjuvants, Immunologic) 8020-83-5 (Mineral Oil) |
| Entry Date(s): | Date Created: 20260512 Date Completed: 20260605 Latest Revision: 20260605 |
| Update Code: | 20260606 |
| DOI: | 10.1016/j.cbpa.2026.112014 |
| PMID: | 42119917 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1531-4332 |
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| DOI: | 10.1016/j.cbpa.2026.112014 |