Academic Journal
The dose-response effects of alcohol on positive and depressed affect in major depressive disorder.
| Τίτλος: | The dose-response effects of alcohol on positive and depressed affect in major depressive disorder. |
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| Συγγραφείς: | Bossom IRL; Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada. Electronic address: isabella.bossom@dal.ca., DiBonaventura F; Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada; Department of Psychology, Saint Mary's University, Halifax, NS, Canada. Electronic address: franco.dibonaventura@smu.ca., Hagen AEF; Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada; Mental Health and Addictions Program, Nova Scotia Health Authority, Halifax, NS, Canada. Electronic address: mandyhagen@proton.me., Snooks T; Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada. Electronic address: tfsnooks@dal.ca., Stewart SH; Department of Psychology & Neuroscience, Dalhousie University, Halifax, NS, Canada; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. Electronic address: sstewart@dal.ca. |
| Πηγή: | Behaviour research and therapy [Behav Res Ther] 2026 Jul; Vol. 202, pp. 105065. Date of Electronic Publication: 2026 May 05. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0372477 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-622X (Electronic) Linking ISSN: 00057967 NLM ISO Abbreviation: Behav Res Ther Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Original Publication: Oxford [etc.] |
| Ιατρικοί όροι (MeSH): | Major Depressive Disorder*/psychology , Major Depressive Disorder*/complications , Affect*/drug effects , Ethanol*/administration & dosage , Ethanol*/pharmacology , Ethanol*/blood , Alcohol Drinking*/psychology, Humans ; Female ; Male ; Adult ; Dose-Response Relationship, Drug ; Young Adult ; Blood Alcohol Content |
| Περίληψη: | Major depressive disorder (MDD) and alcohol use disorder (AUD) commonly co-occur; those with MDD tend to drink more heavily than others. Efforts to regulate mood in MDD may underlie the predisposition for AUD in this population, and mood regulation may require higher alcohol doses. However, the specific aspects of affect impacted by orally-administered alcohol at different doses and timepoints along the blood alcohol concentration (BAC) curve remain unclear among those with MDD. Affect consists of two independent dimensions-positive and negative (including depressed) affect-with MDD involving both low positive and high depressed affect. We investigated the effects of low and moderately high alcohol doses (target M peak BAC levels = .04% and .08%, respectively) on changes over time in positive and depressed affect in people with MDD. Sixty participants (M age = 26.90 years; 58% women) were randomized to one of three beverage conditions (no, low, and moderately high alcohol doses), completed measures of positive and depressed affect, and provided subjective intoxication and BAC measures at five timepoints. A beverage condition x timepoint x affect type interaction revealed more sustained alleviation of depressed affect and enhancement of positive affect in the moderately high than low dose condition. Only the moderately high dose pushed positive affect above depressed affect at all post-drinking timepoints. Results suggest a dose-response relationship of alcohol in improving affect for people with MDD. The more sustained affective consequences of moderately high alcohol doses might reinforce heavier drinking behaviours in those with MDD, placing them at increased risk for AUD development. (Crown Copyright © 2026. Published by Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest On behalf of the authors, I attest that none of the authors/co-authors of this manuscript have any conflicts of interest to declare in relation to the content presented in this paper. |
| Contributed Indexing: | Keywords: Alcohol; Depressed affect; Depression; Dose-response; Positive affect |
| Substance Nomenclature: | 3K9958V90M (Ethanol) 0 (Blood Alcohol Content) |
| Entry Date(s): | Date Created: 20260512 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.brat.2026.105065 |
| PMID: | 42119373 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-622X |
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| DOI: | 10.1016/j.brat.2026.105065 |