Academic Journal
Phytochemical characterization of Zingiber striolatum flower bud and its anti-inflammatory effects in vitro and in vivo.
| Τίτλος: | Phytochemical characterization of Zingiber striolatum flower bud and its anti-inflammatory effects in vitro and in vivo. |
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| Συγγραφείς: | Zhao H; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China., Long D; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China., Jin L; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China., Zhao X; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China., Zhang T; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China., Hong Y; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China., Tian M; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China. Electronic address: mytian@gzu.edu.cn., Zhou Y; National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food, Guizhou University, Guiyang 550025, China; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China. Electronic address: yingzhou71@yeah.net. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Aug 15; Vol. 178, pp. 109974. Date of Electronic Publication: 2026 May 09. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Flowers*/chemistry , Colitis*/drug therapy , Colitis*/chemically induced , Colitis*/pathology , Colitis*/metabolism , Zingiberaceae*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology , Anti-Inflammatory Agents, Non-Steroidal*/chemistry , Anti-Inflammatory Agents, Non-Steroidal*/isolation & purification , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification, Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Cytokines/metabolism ; Cytokines/antagonists & inhibitors ; NF-kappa B/metabolism ; Animals ; Mice ; RAW 264.7 Cells ; Dextran Sulfate ; Male ; Dose-Response Relationship, Drug ; Molecular Structure ; Structure-Activity Relationship ; Mice, Inbred C57BL |
| Περίληψη: | As a common vegetable, Zingiber striolatum flower bud is used in ethnic medicine to treat colitis. This study analyzed the phytochemical characterization of Z. striolatum flower bud ethanol extract (EE) and water extract (WE) and first assessed the anti-inflammatory effects of Z. striolatum flower bud EE in vitro and in vivo. Z. striolatum flower bud EE and WE were rich in phenolic and flavonoid compounds, and a total of 46 constituents were putatively identified, including 9 phenols and 15 flavonoids. In LPS-mediated RAW264.7 macrophages, EE inhibited ROS overproduction and activation of MAPK and NF-κB pathways, which in turn reduced the generation of inflammatory mediators (PGE (Copyright © 2024. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Colitis; MAPK; NF-κB; Phytochemical composition; Zingiber striolatum |
| Substance Nomenclature: | 0 (Lipopolysaccharides) 0 (Cytokines) 0 (Phytochemicals) 0 (Plant Extracts) 9042-14-2 (Dextran Sulfate) 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Anti-Inflammatory Agents) 0 (NF-kappa B) |
| Entry Date(s): | Date Created: 20260512 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.bioorg.2026.109974 |
| PMID: | 42119209 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.109974 |