Academic Journal
Porous organic framework materials for the separation of natural products: A comparative study of separation mechanisms in metal-organic frameworks and covalent organic frameworks.
| Τίτλος: | Porous organic framework materials for the separation of natural products: A comparative study of separation mechanisms in metal-organic frameworks and covalent organic frameworks. |
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| Συγγραφείς: | Zhu T; Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; National Center for Anti-cancer Natural Medicine Engineering, Harbin 150076, China., Li X; Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China., Liu B; Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; National Center for Anti-cancer Natural Medicine Engineering, Harbin 150076, China. Electronic address: tianxiaguixinaa@163.com., Zheng W; School of Pharmacy, Harbin University of Commerce, Harbin 150076, China., Chen N; Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China; National Center for Anti-cancer Natural Medicine Engineering, Harbin 150076, China., Zhang L; Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin 150076, China. |
| Πηγή: | Journal of chromatography. A [J Chromatogr A] 2026 Aug 02; Vol. 1780, pp. 467070. Date of Electronic Publication: 2026 May 07. |
| Τύπος έκδοσης: | Journal Article; Review; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam ; New York : Elsevier, 1993- |
| Ιατρικοί όροι (MeSH): | Biological Products*/isolation & purification , Biological Products*/chemistry , Metal-Organic Frameworks*/chemistry , Solid Phase Extraction*/methods, Porosity ; Adsorption |
| Περίληψη: | The efficient isolation and purification of natural products are critical for fundamental research, drug discovery, and quality control. However, the complexity of sample matrices and the structural diversity of target analytes present significant challenges to conventional separation media. Traditional sorbents, including silica-based and polymeric phases, exhibit limitations regarding pore-structure tunability, surface chemistry customization, and stability, which can restrict selectivity and resolution. Conversely, Metal-Organic Frameworks (MOFs) and Covalent Organic Frameworks (COFs) possess ordered pore topologies and tailorable surface functionalities, providing a robust platform for elucidating structure-retention relationships. This review systematically compares the progress of these two materials in natural product separation from a separation science perspective. At the preparation level, solvothermal methods and post-modification strategies play a key role in regulating pore regularity and the surface microenvironment. At the mechanistic level, MOFs rely on metal-site-driven coordination and Lewis acid-base interactions, supplemented by physical adsorption, making them suitable for broad-spectrum enrichment; COFs, on the other hand, rely on a synergistic network of multiple weak interactions within their all-organic frameworks. By introducing chemical recognition sites such as boronic acid affinity, they achieve highly selective separation of molecules with specific functional groups. Analysis using flavonoids as a typical case study indicates that MOFs excel at high-capacity capture driven by metal coordination, while COFs demonstrate superior precision in recognition conferred by their covalent frameworks; the mechanisms of the two are complementary. This paper discusses key development directions, including stability, green large-scale synthesis, and rational design, providing a systematic theoretical framework for the development of next-generation separation materials. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Bing Liu reports article publishing charges was provided by Science and Technology Department of Heilongjiang Province, China. Ting Zhu reports financial support was provided by Department of Human Resources and Social Security of Heilongjiang Province, China. Bing Liu reports article publishing charges was provided by Education Department of Heilongjiang Province, China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Chromatography; Covalent organic frameworks; Flavonoids; Metal-organic frameworks; Solid-phase extraction |
| Substance Nomenclature: | 0 (Biological Products) 0 (Metal-Organic Frameworks) |
| Entry Date(s): | Date Created: 20260511 Date Completed: 20260716 Latest Revision: 20260716 |
| Update Code: | 20260717 |
| DOI: | 10.1016/j.chroma.2026.467070 |
| PMID: | 42114344 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-3778 |
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| DOI: | 10.1016/j.chroma.2026.467070 |