Academic Journal
Effects of dietary benzoic acid combined with cinnamon essential oil on growth performance, antioxidant capacity, immune function, and gut health in broiler, chickens with necrotic enteritis.
| Τίτλος: | Effects of dietary benzoic acid combined with cinnamon essential oil on growth performance, antioxidant capacity, immune function, and gut health in broiler, chickens with necrotic enteritis. |
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| Συγγραφείς: | Long MH; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., Zhao X; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., Hu Z; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., E X; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., Hu W; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., He Q; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., Lin J; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China., Lin X; State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Provincial Key Laboratory of Livestock Disease Prevention, Key Laboratory for prevention and control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China. Electronic address: linxuhui1988@163.com., Hu Y; Nuacid Nutrition Co.,Ltd, Qingyuan, Guangdong 511545, PR China. Electronic address: 61368851@163.com. |
| Πηγή: | Poultry science [Poult Sci] 2026 Aug; Vol. 105 (8), pp. 107060. Date of Electronic Publication: 2026 May 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 0401150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3171 (Electronic) Linking ISSN: 00325791 NLM ISO Abbreviation: Poult Sci Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2020- : [Cambridge, UK] : Elsevier Original Publication: Champaign Il : Poultry Science Association |
| Ιατρικοί όροι (MeSH): | Chickens*/growth & development , Chickens*/immunology , Poultry Diseases*/immunology , Poultry Diseases*/microbiology , Poultry Diseases*/prevention & control , Enteritis*/veterinary , Enteritis*/microbiology , Enteritis*/immunology , Enteritis*/prevention & control , Clostridium Infections*/veterinary , Clostridium Infections*/immunology , Clostridium Infections*/microbiology , Clostridium Infections*/prevention & control , Oils, Volatile*/administration & dosage , Oils, Volatile*/metabolism , Antioxidants*/metabolism , Benzoic Acid*/administration & dosage , Benzoic Acid*/metabolism , Cinnamomum zeylanicum*/chemistry , Immunity, Innate*/drug effects, Diet/veterinary ; Clostridium perfringens/physiology ; Dietary Supplements/analysis ; Animal Feed/analysis ; Necrosis/veterinary ; Necrosis/microbiology ; Necrosis/immunology ; Animals ; Random Allocation ; Dose-Response Relationship, Drug ; Male |
| Περίληψη: | This study aims to investigate the efficacy and mechanism of action of a benzoic acid combined with cinnamon essential oil complex (SLLEO) in preventing and controlling necrotic enteritis (NE) in broiler chickens caused by Clostridium perfringens infection. A total of 300 one-day-old 817 broiler chickens were randomly divided into five groups, with six replicates per group and ten birds per replicate. The control group (CON) and challenge group (CP) were fed a basal diet; the low, medium, and high-dose benzoic acid combined with cinnamon essential oil groups (SLLEO-L, SLLEO-M, SLLEO-H) were fed basal feed supplemented with 0.1%, 0.2%, and 0.3% benzoic acid combined with cinnamon essential oil, respectively. The animal experiment lasted 35 days. Results indicate that supplementing feed with benzoic acid combined with cinnamon essential oil (SLLEO) effectively mitigates the adverse effects of NE infection on broiler chickens. Compared to the Clostridium perfringens infection model, SLLEO significantly increased the average daily weight gain of infected chickens while reducing abnormally elevated liver and bursa of Fabricius indices (P < 0.05). SLLEO elevated total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) activity in plasma, liver, and jejunal mucosa while decreasing malondialdehyde (MDA) content (P < 0.05). Significantly increased plasma immunoglobulin A (IgA) levels, markedly elevated the villus height-to-crypt depth ratio (VH/CD), and reduced intestinal lesion scores (P < 0.05). Additionally, SLLEO downregulated mRNA expression of the proinflammatory factor TNF-α in the jejunum while upregulating the expression of the anti-inflammatory factor IL-10 and tight junction proteins ZO-1, Occludin, Claudin-1, and mucin MUC-2 (P < 0.05).In summary, dietary supplementation with SLLEO effectively mitigated growth performance decline in broilers caused by Clostridium perfringens infection, improved antioxidant function, alleviated immune organ hypertrophy, regulated plasma immunoglobulin levels, restored intestinal morphology, downregulated pro-inflammatory factors while upregulating anti-inflammatory factors, and enhanced intestinal barrier function by increasing tight junction protein and mucin gene expression. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Disclosures The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: Benzoic acid; Broiler chickens; Cinnamon essential oil; Gut health; Necrotic enteritis |
| Substance Nomenclature: | 0 (Oils, Volatile) 0 (Antioxidants) 8SKN0B0MIM (Benzoic Acid) |
| Entry Date(s): | Date Created: 20260511 Date Completed: 20260724 Latest Revision: 20260724 |
| Update Code: | 20260724 |
| PubMed Central ID: | PMC13191231 |
| DOI: | 10.1016/j.psj.2026.107060 |
| PMID: | 42114283 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1525-3171 |
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| DOI: | 10.1016/j.psj.2026.107060 |