Academic Journal
Dynamics of intra- and inter-regional activities of the auditory 'Where' pathway during sound localization: An fMRI study.
| Τίτλος: | Dynamics of intra- and inter-regional activities of the auditory 'Where' pathway during sound localization: An fMRI study. |
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| Συγγραφείς: | Su J; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China., Tong R; School of Engineering Medicine, Beihang University, Beijing 100191, China., Feng W; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China., Liang Y; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China., Wei J; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China., Geng X; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China., Sun L; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China. Electronic address: sunliwei@ccmu.edu.cn., Zhang X; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China. Electronic address: zhangxu@ccmu.edu.cn., Li C; School of Biomedical Engineering, Capital Medical University, Beijing 100069, China; Beijing Key Laboratory of Clinical Engineering Solutions for Mental Health, Capital Medical University, Beijing 100069, China. Electronic address: lichunlin1981@163.com. |
| Πηγή: | Hearing research [Hear Res] 2026 Jul; Vol. 477, pp. 109650. Date of Electronic Publication: 2026 May 01. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7900445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5891 (Electronic) Linking ISSN: 03785955 NLM ISO Abbreviation: Hear Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Sound Localization*/physiology , Auditory Cortex*/physiology , Auditory Pathways*/physiology , Brain Mapping*/methods , Magnetic Resonance Imaging*, Humans ; Acoustic Stimulation ; Male ; Adult ; Female ; Young Adult ; Time Factors ; Models, Neurological ; Hemodynamics |
| Περίληψη: | Previous neuroimaging studies suggested that sound localization was accomplished by a cortical "where" pathway, which originated from auditory cortex and went through parietal and prefrontal regions. While previous studies focus on regional activity and functional connectivity patterns of such cortical network, the dynamics of intra- and inter-regional activities of auditory "where" pathway during sound localization remains unclear. In the present study, we investigate such question by applying hemodynamic response function (HRF) analysis and dynamic causal modeling (DCM) to functional magnetic resonance imaging (fMRI) data collected as participants passively listened to auditory stimuli from five horizontal locations (-90°, -45°, 0°, 45°, 90°). HRF analysis revealed hemispheric asymmetry of regional dynamics and potential bottom-up information flow along the "where" pathway during sound localization. DCM demonstrated that sound localization induced excitatory modulatory effects along the ascending auditory pathway and inhibitory modulatory effects along the descending auditory pathway. In addition, modulation of interhemispheric effective connectivity was found between bilateral Heschl's gyri. Overall, the present study probes dynamics of intra- and inter-regional activities of auditory "where" pathway during sound localization, which provides novel insights into the integration of spatial information within the cortical auditory network. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no competing interests. |
| Σχόλια: | Erratum in: Hear Res. 2026 Jul 11:109724. doi: 10.1016/j.heares.2026.109724.. (PMID: 42436097) |
| Contributed Indexing: | Keywords: Sound localization;functional Magnetic Resonance Imaging;Hemodynamic response function;Effective connectivity;Dynamic causal modeling |
| Entry Date(s): | Date Created: 20260511 Date Completed: 20260610 Latest Revision: 20260711 |
| Update Code: | 20260712 |
| DOI: | 10.1016/j.heares.2026.109650 |
| PMID: | 42114180 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-5891 |
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| DOI: | 10.1016/j.heares.2026.109650 |