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Flupyradifurone impairs the processing of sound signals by the ascending interneurons AN1 and AN2 that convey auditory information to the cricket brain.

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Τίτλος: Flupyradifurone impairs the processing of sound signals by the ascending interneurons AN1 and AN2 that convey auditory information to the cricket brain.
Συγγραφείς: Christian M; Institute for Zoology and Evolutionary Research, Friedrich Schiller University Jena, Erbertstraße 1, 07743, Jena, Germany. marcelo.christian@uni-jena.de., Nowotny M; Institute for Zoology and Evolutionary Research, Friedrich Schiller University Jena, Erbertstraße 1, 07743, Jena, Germany., Schöneich S; Institute for Zoology and Evolutionary Research, Friedrich Schiller University Jena, Erbertstraße 1, 07743, Jena, Germany. stefan.schoeneich@uni-jena.de.
Πηγή: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2026 Jul; Vol. 212 (4), pp. 617-632. Date of Electronic Publication: 2026 May 11.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Germany NLM ID: 101141792 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1351 (Electronic) Linking ISSN: 03407594 NLM ISO Abbreviation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin ; New York : Springer, c2001-
Ιατρικοί όροι (MeSH): Gryllidae*/drug effects , Gryllidae*/physiology , Interneurons*/drug effects , Interneurons*/physiology , Pyridines*/toxicity , Auditory Perception*/drug effects , Insecticides*/toxicity , Brain*/drug effects , Brain*/physiology, Auditory Pathways/drug effects ; Auditory Pathways/physiology ; Action Potentials/drug effects ; 4-Butyrolactone/analogs & derivatives ; Animals ; Acoustic Stimulation ; Male ; Dose-Response Relationship, Drug
Περίληψη: Flupyradifurone is a butenolide insecticide with growing agricultural significance as a substitute for classical neonicotinoids, which have been partially banned in the EU and other countries. It also acts as an agonist on acetylcholine receptors in the insect central nervous system, but its neurophysiological effects on individual interneurons are poorly understood. Here, we investigated the effects of sublethal flupyradifurone intoxication on the neural processing of auditory information in the field cricket Gryllus bimaculatus. Using a suction electrode on the brain surface, we recorded the spiking activity of the two ascending auditory interneurons AN1 and AN2 while injecting the insecticide into the prothorax. Flupyradifurone caused a dose-dependent decrease in sound-evoked spike responses and an increase in spontaneous spiking activity in both ascending auditory interneurons, eventually leading up to a collapse of all spiking activity the highest dose tested (20 µl of 10- 3 mol/l). The substantial increase of spontaneous spiking activity in AN1 and AN2, which started with 20 µl of 10- 5 mol/l flupyradifurone treatment, will mask the neuronal coding of relevant acoustic signals required for auditory feature detection in the higher brain circuits. Field crickets rely on AN1 to transmit low-frequency auditory information for pattern recognition in phonotactic mate finding, and on AN2 to transmit high-frequency auditory information for sound source localization in predator avoidance behaviour. The disruption of auditory processing at the level of ascending interneurons by this insecticide will negatively impact the chances for reproduction and survival in crickets.
(© 2026. The Author(s).)
Competing Interests: Declarations. Conflict of interest: The authors declare no conflict of interest.
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Contributed Indexing: Keywords: Auditory processing; Field crickets; Flupyradifurone; Identified neurons; Insect hearing; Insecticide
Substance Nomenclature: 0 (Pyridines)
8H7JT159D0 (flupyradifurone)
0 (Insecticides)
OL659KIY4X (4-Butyrolactone)
Entry Date(s): Date Created: 20260511 Date Completed: 20260724 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13396037
DOI: 10.1007/s00359-026-01814-4
PMID: 42113275
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1432-1351
DOI:10.1007/s00359-026-01814-4