Academic Journal
Incidence trends, outcomes, and factors associated with mortality in multisystem inflammatory syndrome in children: A nationwide study in Thailand during 2021-2023.
| Τίτλος: | Incidence trends, outcomes, and factors associated with mortality in multisystem inflammatory syndrome in children: A nationwide study in Thailand during 2021-2023. |
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| Συγγραφείς: | Niamsanit S; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Sitthikarnkha P; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Techasatian L; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Saengnipanthkul S; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Kosalaraksa P; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Thepsuthammarat K; Clinical Epidemiology Unit, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Uppala R; Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Electronic address: rattapon@kku.ac.th. |
| Πηγή: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2026 Aug; Vol. 169, pp. 108766. Date of Electronic Publication: 2026 May 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: Hamilton, ON : Elsevier Original Publication: Hamilton, ON : Decker, c1996- |
| Ιατρικοί όροι (MeSH): | Systemic Inflammatory Response Syndrome*/mortality , Systemic Inflammatory Response Syndrome*/epidemiology , COVID-19*/mortality , COVID-19*/complications , COVID-19*/epidemiology, Thailand/epidemiology ; Hospital Mortality/trends ; Hospitalization/statistics & numerical data ; Humans ; Male ; Female ; Child, Preschool ; Incidence ; Child ; Retrospective Studies ; Adolescent ; Infant ; SARS-CoV-2 ; Risk Factors |
| Περίληψη: | Objectives: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inflammatory condition. This study described MIS-C epidemiology and outcomes in Thailand during 2021-2023 and identified predictors of in-hospital death. Methods: A nationwide retrospective cohort study used Thai National Health Security Office (NHSO) inpatient data. Children aged 1 month to <18 years with MIS-C (ICD-10-TM codes U10 and U10.9) were included. Severe manifestations, organ dysfunction, and procedures were identified using ICD-10-TM, and ICD-9-CM codes. Logistic regression was used to evaluate mortality predictors. Results: Among 634 MIS-C hospitalizations (59.2% male; median age 6 years), national incidence peaked at 3.2 per 100,000 in 2022. In-hospital mortality was 3.2% with regional heterogeneity. Severe cardiac manifestations occurred in 37.4% and severe respiratory manifestations in 12.0%. Malignancy (adjusted odds ratio [AOR] 17.13; 95% confidence interval [95% CI] 1.84-159.92) and disseminated intravascular coagulation (DIC) (AOR 14.16; 95% CI: 2.10-95.37) independently predicted mortality. Conclusion: MIS-C burden peaked in 2022 with regional variation. Early risk stratification and timely critical care with advanced organ support remains essential to optimize survival. (Copyright © 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors have no competing interests to declare. |
| Contributed Indexing: | Keywords: Incidence; Mortality; Multisystem inflammatory syndrome in children; SARS-CoV-2; Thailand |
| SCR Disease Name: | pediatric multisystem inflammatory disease, COVID-19 related |
| Entry Date(s): | Date Created: 20260508 Date Completed: 20260615 Latest Revision: 20260615 |
| Update Code: | 20260616 |
| DOI: | 10.1016/j.ijid.2026.108766 |
| PMID: | 42102901 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-3511 |
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| DOI: | 10.1016/j.ijid.2026.108766 |