Cubic Millimeter High Resolution 3D Inner-Volume GRASE (IV-GRASE) CEST MRI Using T1-Integrated Variable Density CAIPI Sampling With Temporal Random Walk: A Feasibility Study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Cubic Millimeter High Resolution 3D Inner-Volume GRASE (IV-GRASE) CEST MRI Using T1-Integrated Variable Density CAIPI Sampling With Temporal Random Walk: A Feasibility Study.
Συγγραφείς:	Kim H; Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Park S; Department of Intelligent Electronics and Computer Engineering, Chonnam National University, Gwangju, Republic of Korea., Chung JJ; Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA., Kim J; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Hoang KB; Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA., Hu R; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA., Olson J; Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Feinberg DA; Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.; Advanced MRI Technologies, Sebastopol, California, USA., Sun PZ; Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Πηγή:	Magnetic resonance in medicine [Magn Reson Med] 2026 Sep; Vol. 96 (3), pp. 1283-1292. Date of Electronic Publication: 2026 May 08.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Wiley Country of Publication: United States NLM ID: 8505245 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-2594 (Electronic) Linking ISSN: 07403194 NLM ISO Abbreviation: Magn Reson Med Subsets: MEDLINE
Imprint Name(s):	Publication: 1999- : New York, NY : Wiley Original Publication: San Diego : Academic Press
Ιατρικοί όροι (MeSH):	Magnetic Resonance Imaging/methods , Imaging, Three-Dimensional/methods , Image Processing, Computer-Assisted*/methods, Humans ; Feasibility Studies ; Phantoms, Imaging ; Algorithms ; Artifacts ; Reproducibility of Results
Περίληψη:	Purpose: To develop a cubic-millimeter, high-resolution CEST MRI sequence with enhanced efficiency and quantitative stability. Methods: The sequence combined an inversion-recovery T1 module and a multi-offset CEST module, both acquired with inner-volume GRASE (IV-GRASE) readout. Acquisition efficiency was improved using variable-density random-walk sampling, and reconstruction employed a self-calibrated joint framework with sparsity and low-rank constraints to leverage redundancy across T1 and CEST datasets. Feasibility was evaluated in phantoms and preliminary patient studies. Results: The framework enabled simultaneous T1 and CEST imaging with reduced artifacts, improved quantitative stability, and efficient high-resolution reconstruction. Phantom experiments demonstrated accurate T1 and Z-spectral measurements with inherently co-registered datasets. Preliminary patient imaging revealed heterogeneity within the diseased region and exchange-dependent relaxation contrast, clearly differentiating it from contralateral normal tissue. Conclusion: The proposed hybrid T1-CEST MRI sequence provides efficient, artifact-reduced, and quantitatively reliable high-resolution imaging in a single acquisition, advancing the feasibility of quantitative CEST analysis. (© 2026 International Society for Magnetic Resonance in Medicine.)
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Grant Information:	Emory School of Medicine, I3 Medical Technology Research Award; Georgia Tech/Emory Biolocity program; UL1-TR002378 United States TR NCATS NIH HHS; RS-2025-25398164 Basic Science Research Program through the National Research Foundation of Korea; IITP-2026-RS-2022-00156287 Institute of Information & Communications Technology Planning & Evaluation (IITP)-Innovative Human Resource Development for Local Intellectualization program; RS-2024-00357917 National Research Foundation of Korea
Contributed Indexing:	Keywords: 3D; chemical exchange saturation transfer (CEST); gradient and spin echo (GRASE); random‐walk sampling
Entry Date(s):	Date Created: 20260508 Date Completed: 20260702 Latest Revision: 20260702
Update Code:	20260703
DOI:	10.1002/mrm.70397
PMID:	42099184
Βάση Δεδομένων:	MEDLINE

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ISSN:	1522-2594
DOI:	10.1002/mrm.70397