Academic Journal
Should we longitudinally monitor blood viscosity in patients with sickle cell anemia?
| Τίτλος: | Should we longitudinally monitor blood viscosity in patients with sickle cell anemia? |
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| Συγγραφείς: | Connes P; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France. Electronic address: philippe.connes@univ-lyon1.fr., Martin M; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France., Catella J; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Renoux C; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-Site, Hospices Civils de Lyon, Lyon, France., Asghariastanehei B; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France., Tressières B; Centre d'Investigation Clinique (CIC), Inserm, 1424, Guadeloupe, France., Boisson C; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-Site, Hospices Civils de Lyon, Lyon, France., Rage M; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France., Joly P; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-Site, Hospices Civils de Lyon, Lyon, France., Poutrel S; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Peugnet AL; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Institut d'Hématologie et d'Oncologie Pédiatrique (IHOPe), Hospices Civils de Lyon, Lyon, France., Garnier N; Institut d'Hématologie et d'Oncologie Pédiatrique (IHOPe), Hospices Civils de Lyon, Lyon, France., Halfon-Domenech C; Institut d'Hématologie et d'Oncologie Pédiatrique (IHOPe), Hospices Civils de Lyon, Lyon, France., Virot E; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Cannas G; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Hot A; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Service de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France., Stauffer E; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France; Centre de Médecine du Sommeil et des Maladies Respiratoires, Hospices Civils de Lyon, Hôpital Croix Rousse, Lyon, France; Service d'Explorations Fonctionnelles Respiratoires-Médecine du sport et de l'activité physique, Hospices Civils de Lyon, Lyon, France., Nader E; Laboratory LIBM UR7424, Vascular Biology and Red Blood Cell Team, University of Lyon, Lyon, France. |
| Πηγή: | Blood cells, molecules & diseases [Blood Cells Mol Dis] 2026 Jul; Vol. 119, pp. 103008. Date of Electronic Publication: 2026 May 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 9509932 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0961 (Electronic) Linking ISSN: 10799796 NLM ISO Abbreviation: Blood Cells Mol Dis Subsets: MEDLINE |
| Imprint Name(s): | Publication: <1996-> : Orlando, FL : Academic Press Original Publication: La Jolla, Calif. : Blood Cells Foundation, 1995- |
| Ιατρικοί όροι (MeSH): | Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/complications , Blood Viscosity*, Biomarkers/blood ; Humans ; Female ; Male ; Adult ; Vaso-Occlusive Crises ; Longitudinal Studies ; Adolescent ; Young Adult ; Child |
| Περίληψη: | Blood viscosity is recognized as a key determinant in the pathophysiology of vaso-occlusive crises (VOC) in sickle cell anemia (SCA). However, its longitudinal relationship with changes in VOC frequency over time remains poorly understood. The present study analyzed the associations between the changes in blood rheological parameters and the changes (delta) in the rate of VOC over time in 63 SCA patients. VOC rates (calculated over the 3 years preceding each blood sampling) and biological parameters were measured at two separate occasions, spaced by at least 3 yrs. (mean difference between the two measurements: 5.7 ± 2.0 years). A positive correlation was observed between the delta-VOC rate and the percentages of change in white blood cells, lactate dehydrogenase and blood viscosity. A multivariate linear regression was performed to test the independent association between the delta-VOC rate and the percentages of change in these biological parameters. The model was statistically significant (R2 = 0.47, p < 0.01), and blood viscosity was the only parameter independently associated with the percentage of change in VOC rate (β coefficient = 0.025, 95% CI: 0.009-0.040, p < 0.01). Our study demonstrated that steady-state blood viscosity is a valuable biomarker in SCA, given its associations with temporal variations of VOC frequency. (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest No conflict of interest to declare. |
| Contributed Indexing: | Keywords: Blood viscosity; Sickle cell anemia; Vaso-occlusive crises |
| Substance Nomenclature: | 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20260507 Date Completed: 20260607 Latest Revision: 20260610 |
| Update Code: | 20260610 |
| DOI: | 10.1016/j.bcmd.2026.103008 |
| PMID: | 42096761 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1096-0961 |
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| DOI: | 10.1016/j.bcmd.2026.103008 |